PINOCEMBRIN
- CAS No.
- 480-39-7
- Chemical Name:
- PINOCEMBRIN
- Synonyms
- 5,7-DIHYDROXYFLAVANONE;Picembrin;PINOCEMBRIN;pinocemberin;dihydrochrysin;Pinocembrin-RM;PINOCEMBRIN(RG);(+)-Pinocembrin;galanginflavanone;Pinocembrin (Standard)
- CBNumber:
- CB3378883
- Molecular Formula:
- C15H12O4
- Molecular Weight:
- 256.25
- MDL Number:
- MFCD06858345
- MOL File:
- 480-39-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 202 °C |
|---|---|
| Boiling point | 511.1±50.0 °C(Predicted) |
| Density | 1.386±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in ethanol and methan |
| form | powder |
| pka | 7.50±0.40(Predicted) |
| color | White |
| Major Application | food and beverages |
| InChI | 1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1 |
| InChIKey | URFCJEUYXNAHFI-ZDUSSCGKSA-N |
| SMILES | OC1=C(C(C[C@@H](C2=CC=CC=C2)O3)=O)C3=CC(O)=C1 |
| LogP | 3.225 (est) |
| FDA UNII | 8T7C8CH791 |
| EPA Substance Registry System | 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- (480-39-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 24/25 |
| WGK Germany | WGK 2 |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
PINOCEMBRIN price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P5239 | Pinocembrin analytical standard, ≥95.0% (HPLC), solid | 480-39-7 | 50 mg | $342 | 2026-04-30 | Buy |
| Cayman Chemical | 29852 | Pinocembrin ≥95% | 480-39-7 | 10mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 29852 | Pinocembrin ≥95% | 480-39-7 | 50mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 29852 | Pinocembrin ≥95% | 480-39-7 | 100mg | $400 | 2026-04-30 | Buy |
| Cayman Chemical | 29852 | Pinocembrin ≥95% | 480-39-7 | 250mg | $876 | 2026-04-30 | Buy |
PINOCEMBRIN Chemical Properties,Uses,Production
Description
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities. It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 μM. Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH). It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy. Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.
Chemical Properties
Solid
Uses
Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c.
Definition
ChEBI: Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one.
References
[1] AZHAR RASUL. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities.[J]. BioMed Research International, 2013: 379850. DOI: 10.1155/2013/379850
[2] JUN GAO . Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor[J]. Biomedicine & Pharmacotherapy, 2019, 120: Article 109505. DOI: 10.1016/j.biopha.2019.109505
[3] XI LAN. Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia[J]. Brain, Behavior, and Immunity, 2017, 61: Pages 326-339. DOI: 10.1016/j.bbi.2016.12.012
[4] JESSICA GRANADOS-PINEDA. Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy.[J]. Molecules, 2018, 23 4. DOI: 10.3390/molecules23040852
[5] LANAN WASSY SOROMOU . In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses[J]. International immunopharmacology, 2012, 14 1: Pages 66-74. DOI: 10.1016/j.intimp.2012.06.009
PINOCEMBRIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
| Shanghai Ruji Biology Technology Co., Ltd. | +86-21-65211385-8001 36031160 | sales@shruji.com | China | 3223 | 55 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
View Lastest Price from PINOCEMBRIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Pinocembrin / Herb cardamom extract
480-39-7
|
1kg | 98% | 1000 | Xi an Biohorlden Industry Trade Co Ltd | ||
 |
2026-08-25 | Pinocembrin
480-39-7
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | ||
 |
2026-08-07 | PINOCEMBRIN
480-39-7
|
$1.00-2.10 | 1KG | 99% | 20000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- Pinocembrin / Herb cardamom extract
480-39-7
- 98%
- Xi an Biohorlden Industry Trade Co Ltd
-
- Pinocembrin
480-39-7
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- PINOCEMBRIN
480-39-7
- $1.00-2.10
- 99%
- Shaanxi Dideu Medichem Co. Ltd
