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(R)-(+)-1,1'-Bi-2-naphthol

(R)-(+)-1,1'-Bi-2-naphthol structure

CAS No.: 18531-94-7

Chemical Name:: (R)-(+)-1,1'-Bi-2-naphthol

Synonyms: (R)-BINOL;(R)-1,1'-BI-2-NAPHTHOL;(R,S)-BINOL;(R)-(+)-BINOL;1,1'-BINAPHTHYL-2,2'-DIOL;(S)-[1,1'-BINAPHTHALENE]-2,2'-DIOL;(R)-[1,1'-Binaphthalene]-2,2'-diol;(+)-BINOL;R-1,1'AKOS 90560

CBNumber:: CB3380426

Molecular Formula:: C20H14O2

Molecular Weight:: 286.32

MDL Number:: MFCD00004068

MOL File:: 18531-94-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-04 16:00:12

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(R)-(+)-1,1'-Bi-2-naphthol Properties

Melting point	215-218 °C
alpha	35.5 º (c=1, THF)
Boiling point	388.69°C (rough estimate)
Density	1.301
refractive index	36.0 ° (C=1, THF)
storage temp.	Store below +30°C.
solubility	dioxane: 50 mg/mL, clear
form	Powder
pka	8.29±0.50(Predicted)
color	white to off-white
optical activity	[α]21/D +34°, c = 1 in THF
Water Solubility	Insoluble in water. Solubility in THF within almost transparency). Soluble in dioxane 50 mg/mL.
Merck	14,1226
BRN	3616837
InChI	1S/C20H14O2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChIKey	PPTXVXKCQZKFBN-UHFFFAOYSA-N
SMILES	Oc1ccc2ccccc2c1-c3c(O)ccc4ccccc34
CAS DataBase Reference	18531-94-7(CAS DataBase Reference)
FDA UNII	M6IDZ128WT
UNSPSC Code	12352104
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

T,Xi

Risk Statements

25-36-36/37/38

Safety Statements

26-45-24/25-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

DU3106100

TSCA

HazardClass

6.1

PackingGroup

III

HS Code

29071590

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

Toxicity

LD50 orally in Rabbit: 113 mg/kg

REACH Registrations

Active

Limited Quantities

5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
2		0

(R)-(+)-1,1'-Bi-2-naphthol price More Price(85)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	246948	(R)-(+)-1,1′-Bi(2-naphthol) 99%	18531-94-7	1g	$83.4	2026-04-30	Buy
Sigma-Aldrich	8.14774	(R)-(+)-1,1′-Binaphthyl-2,2′-diol forsynthesis	18531-94-7	10g	$75.1	2026-04-30	Buy
Sigma-Aldrich	246948	(R)-(+)-1,1′-Bi(2-naphthol) 99%	18531-94-7	5g	$194	2026-04-30	Buy
Sigma-Aldrich	8.14774	(R)-(+)-1,1′-Binaphthyl-2,2′-diol forsynthesis	18531-94-7	1g	$35.4	2025-07-31	Buy
TCI Chemical	B1142	(R)-(+)-1,1'-Bi-2-naphthol >98.0%(HPLC)(T)	18531-94-7	5g	$62	2026-04-30	Buy

Product number	Packaging	Price	Buy
246948	1g	$83.4	Buy
8.14774	10g	$75.1	Buy
246948	5g	$194	Buy
8.14774	1g	$35.4	Buy
B1142	5g	$62	Buy

(R)-(+)-1,1'-Bi-2-naphthol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

Chiral binapthol imminium salt precursor. Salts were used for an asymmetric epoxidation of olefins.

Definition

ChEBI: (S)-(-)-1,1'-Bi-2-naphthol is a member of naphthols.

Synthesis

Racemic 1,1'-bi-2-naphthol is resolved via formation of a molecular inclusion complex. The racemate is heated with (S)-proline in acetonitrile under reflux. Upon cooling, a white solid (the molecular inclusion complex) precipitates and is filtered. The white solid is treated with ethanol to give inclusion complex crystals. These crystals are stirred in a two-phase ethyl acetate-water system. After separation, the organic phase is processed to yield enantiopure (S)-product. The acetonitrile filtrate is processed to yield enantiopure (R)-product. The aqueous phase allows recovery of (S)-proline.

Purification Methods

Dissolve it in cold 2.5N NaOH, extract with CH2Cl2, and acidify with 5% HCl. Collect the white precipitate and recrystallise it from aqueous EtOH and dry it in a vacuum [Akimoto & Yamada Tetrahedron 27 5999 1971]. It is optically stable in dioxane-water (100o/24hours). Racemisation: 72% in 1.2N HCl at 100o/24hours and 68% in 0.67M KOH in BuOH at 118o/23hours [Kyba et al. J Am Chem Soc 95 2693 1973]. It has also been crystallised from *C6H6 (solubility is 1%) using Norite or aqueous EtOH after chromatography through silica gel, eluting with Me2CO/*C6H6. [Kyba et al. J Org Chem 42 4173 1977; see also Brussee & Jansen Tetrahedron Lett 24 3261 1983, Akimoto & Yamada Tetrahedron 27 5999 1971, Beilstein 6 IV 7020.]

(R)-(+)-1,1'-Bi-2-naphthol synthesis

Synthesis of (R)-(+)-1,1'-Bi-2-naphthol from 2-Naphthol

(R)-(+)-1,1'-Bi-2-naphthol Preparation Products And Raw materials

Raw materials

Copper(II) chloride dihydrate Ethanol Toluene Phosphorus oxitrichloride Triethylamine

(R)-(+)-1-Phenylethylamine L-1-Phenylethylamine Iron chloride hexahydrate Tetrahydrofuran Benzene

Ethyl acetate Dichloromethane 2-Naphthol 1,1'-Bi-2-naphthol

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Preparation Products

(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (R)-(-)-6,6'-Dibromo-1,1'-bi-2-naphthol (R)-(+)-TolBINAP

R-3,3'-Bis(phenyl)-1,1'-bi-2-naphthol

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(R)-(+)-1,1'-Bi-2-naphthol Suppliers

Global( 487)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xinxiang Runyu Material Co., Ltd.	166-166-37336996 15690792173	chenxi.song@runvmat.com	China	282	55
Changzhou shuicao chemical Nes material Industry?Co.,Ltd.	0519-86609972; 13861152845	987349505@qq.com	China	86	58
Shanghai Arbor Chemical Co., Ltd.	021-60451683 15021268886	sales@arborchemical.com	China	765	55
BeiJing Greenchem Technology Co.,Ltd.	131-21959385 18804271668	chemrocking@bjgreenchem.com	China	272	58
Chongqing Botao Biotechnology Co., LTD	15223382610	danny@chemdad.com	China	2034	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Xinxiang Runyu Material Co., Ltd.	55
Changzhou shuicao chemical Nes material Industry?Co.,Ltd.	58
Shanghai Arbor Chemical Co., Ltd.	55
BeiJing Greenchem Technology Co.,Ltd.	58
Chongqing Botao Biotechnology Co., LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84

View Lastest Price from (R)-(+)-1,1'-Bi-2-naphthol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	(R)-(+)-(1,1'-binaphthalene)-2,2'-diol 18531-94-7	$35.00-285.00	1g	0.99	25kg	Shanghai UCHEM Inc.
2026-09-11	(R)-(+)-1,1'-Bi-2-naphthol 18531-94-7	$70.00-100.00	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-09-02	(R)-(+)-1,1'-Bi-2-naphthol 18531-94-7	$2.00-10.00	1KG	99%		Henan Fengda Chemical Co., Ltd

(R)-(+)-(1,1'-binaphthalene)-2,2'-diol
18531-94-7
$35.00-285.00
0.99
Shanghai UCHEM Inc.

(R)-(+)-1,1'-Bi-2-naphthol
18531-94-7
$70.00-100.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

(R)-(+)-1,1'-Bi-2-naphthol
18531-94-7
$2.00-10.00
99%
Henan Fengda Chemical Co., Ltd

(R)-(+)-1,1'-Bi-2-naphthol Spectrum

(R)-(+)-1,1'-Bi-2-naphthol(18531-94-7)¹HNMR (R)-(+)-1,1'-Bi-2-naphthol(18531-94-7)FT-IR (R)-(+)-1,1'-Bi-2-naphthol(18531-94-7)IR (R)-(+)-1,1'-Bi-2-naphthol(18531-94-7)Raman

18531-94-7((R)-(+)-1,1'-Bi-2-naphthol)Related Search:

Phenmedipham Terbinafine hydrochloride 1-Naphthol 2-Naphthol p-Naphtholbenzein

1,1'-Bi-2-naphthol alpha-Naphtholbenzein (R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL (S)-(+)-6'-DIBROMO-1,1'-BI-2-NAPHTHOL,6,6''-DIBROMO-1,1''-BI-2-NAPHTHOL 95+%,racemic-6,6'-Dibromo-1,1'-bi-2-naphthol,min.98% (S)-2'-Methoxy-[1,1']binaphthalenyl-2-ol

1,1'-Binaphthyl-2,2'-diyl hydrogenphosphate (R)-(-)-1,1'-Binaphthol-2,2'-bis(trifluoromethanesulfonate) (R)-(+)-3,3'-Dibromo-1,1'-bi-2-naphthol,99% (S)-(+)-1,1'-Bi-2-naphthyl ditosylate (-1,1'-Bi-2-Naphthol Deacetate

(S)-(-)-1,1'-Bi-2-naphthol (S)-1,1μ-Binaphthalene-2,2μ-diyl bis(trifluoromethanesulfonate), (S)-1,1μ-Bi(2-naphthol) bis(trifluoromethanesulfonate) (R)-1,1'-BI-2-NAPHTHOL DIBENZOATE

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(R)-(+)-BI-2-NAPHTHOL (R)-[1,1']-Binaphth-2-ol, (R)-BINOL (+)-2,2μ-Dihydroxy-1,1μ-dinaphthyl, (R)-(+)-1,1μ-Binaphthalene-2,2μ-diol, (R)-BINOL (R)-(+)-1,1'-Bi-2-naphthol 99% [aR,(+)]-1,1'-Binaphthalene-2,2'-diol [aR,(+)]-Dinaphthol R-(+)-1_Bi-2-naphthol (R)-(+)-1,1'-Bi-2-na (1R)-2,2'-Dihydroxy-[1,1']-binaphthyl (1R)-1,1'-Binaphthalene-2,2'-diol, (R)-BINOL (R)-(+)-BINOL (R)-(+)-2,2'-Dihydroxy-1,1'-binaphthyl (R)-(+)-1,1''-BINAPHTHYL-2,2''-DIOL FOR SY e: (R)-(+)-1,1'-Bi-2-naphtho (R)-1,1'-Binaphthalene-2,2'-diol, (R)-BINOL (R)-(+)-1,1'-Bi-2-naphthol (R)-(+)-2,2'-Dihydroxy-1,1'-dinaphthyl (R)-(+)-1,1'-Bi-2-naphthol, >=99.5% Dihydroxydinaphthylwhitepowder (1R)- [1,1'-Binaphthalene]-2,2'-diol (R)-(+)-1,1'-Bi-2-naphthol (R)-2,2'-Dihydroxy-[1,1']-binaphthyl 99% DI-B-NAPHTHOL AURORA KA-7212 BI-2-NAPHTHOL (-)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL (+)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL (+/-)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL 2,2'-DIHYDROXY-1,1'-DINAPHTHYL 2,2'-DINAPHTHOL (R)-(+)-1,1'-BIS(2-NAPHTHOL) (R)-(+)-1,1'-BINAPHTHYL-2,2'-DIOL (R)-[1,1]-BINAPHTHALENYL-2,2'-DIOL R(+)-1,1'-BINAPHTHALENE-2,2'-DIOL (R)-(+)-1,1'-BI(2,2'-NAPHTHOL) (R)-(+)-1,1-BI-2-NAPHTHOL R-1,1-BI-2-NAPHTHOL R-(+)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL (R)-(+)-2,2'-DIHYDROXY-1,1-BINAPHTHYL (S)-(-)-1,1'-BI(2,2'-NAPHTHOL) S(-)-1,1'-BINAPHTHALENE-2,2'-DIOL (S)-(-)-1,1'-BINAPHTHYL-2,2'-DIOL (S)-[1,1]-BINAPHTHALENYL-2,2'-DIOL (R,S)-BINOL S-(-)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL 1,1'-BINAPHTHYL-2,2'-DIOL [1,1']BINAPHTHALENYL-2,2'-DIOL 1,1'-BI-2,2'-NAPHTHOLS (+/-)-1,1'-BINAPHTHALENE-2,2'-DIOL AKOS 90560 (R)-(+)-1,1’-bi-2-nanphthol (R)-(+)-1,1'-BI-2-NAPHTHOL, 99% (99% EE/ R-(+)-1,1'-Binaphthyl-2.2'-dio R-(+)-1,1'-BI-2-NAPHTHOL/ (R)-(+)BINOL R-(+)-1,1'-Bi-2-naphthol,99%(R)-BINOL 1,1-Binaphthalene-2,2-diol, (1R)- (R)-(+)-1,1'-Bi-2-naphtol (R)-(+)-1,1''-BI(2-NAPTHOL) R-(+)-2,2''-DIHYDROXY-1,1''-DINAPHTHYL (R)-BINOL (R)-1,1 -BI-2-NAPHTHOL & (S)-1,1 -BI-2-NAPHTHO