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(S)-(-)-1,1'-Bi-2-naphthol

(S)-(-)-1,1'-Bi-2-naphthol structure

CAS No.: 18531-99-2

Chemical Name:: (S)-(-)-1,1'-Bi-2-naphthol

Synonyms: (S)-BINOL;(S)-1,1'-BI-2-NAPHTHOL;(S)-(-)-BINOL;S-BINAPHTHOL;(R,S)-BINOL;1,1'-BINAPHTHYL-2,2'-DIOL;(-)-Binol;AKOS 90560;98.0%(T&BI-2-NAPHTHOL

CBNumber:: CB6380427

Molecular Formula:: C20H14O2

Molecular Weight:: 286.32

MDL Number:: MFCD00004068

MOL File:: 18531-99-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-12 09:16:51

Product description	Number	Pack Size	Price
(S)-(?)-1,1′-Bi(2-naphthol) 99%	246956	1g	$51.5
(S)-(?)-1,1′-Bi(2-naphthol) 99%	246956	5g	$64.5
(S)-(-)-1,1'-Bi-2-naphthol >98.0%(HPLC)(T)	B1100	5g	$52
(S)-(-)-1,1'-Bi-2-naphthol >98.0%(HPLC)(T)	B1100	25g	$156
(S)-(−)-1,1''-Bi-2-naphthol ≥98%	70052	1g	$29
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(S)-(-)-1,1'-Bi-2-naphthol Properties

Melting point	215-218 °C
alpha	-35.5 º (c=1, THF)
Boiling point	388.69°C (rough estimate)
Density	1 g/cm³
refractive index	-36.0 ° (C=1, THF)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	dioxane: 50 mg/mL, clear
pka	8.29±0.50(Predicted)
form	Crystals or Crystalline Powder
color	White to light gray
optical activity	[α]22/D 34°, c = 1 in THF
Merck	14,1226
BRN	3592999
InChI	1S/C20H14O2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChIKey	PPTXVXKCQZKFBN-UHFFFAOYSA-N
SMILES	Oc1ccc2ccccc2c1-c3c(O)ccc4ccccc34
CAS DataBase Reference	18531-99-2(CAS DataBase Reference)
FDA UNII	54OT5RRV4C
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P302+P352-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

T,Xi

Risk Statements

25-36-36/37/38

Safety Statements

26-45-24/25-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

DU3106100

TSCA

HazardClass

6.1

PackingGroup

III

HS Code

29072990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

REACH Registrations

Active

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
2		0

(S)-(-)-1,1'-Bi-2-naphthol price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	246956	(S)-(?)-1,1′-Bi(2-naphthol) 99%	18531-99-2	1g	$51.5	2026-04-30	Buy
Sigma-Aldrich	246956	(S)-(?)-1,1′-Bi(2-naphthol) 99%	18531-99-2	5g	$64.5	2026-04-30	Buy
TCI Chemical	B1100	(S)-(-)-1,1'-Bi-2-naphthol >98.0%(HPLC)(T)	18531-99-2	5g	$52	2026-04-30	Buy
TCI Chemical	B1100	(S)-(-)-1,1'-Bi-2-naphthol >98.0%(HPLC)(T)	18531-99-2	25g	$156	2026-04-30	Buy
Cayman Chemical	70052	(S)-(−)-1,1''-Bi-2-naphthol ≥98%	18531-99-2	1g	$29	2026-04-30	Buy

Product number	Packaging	Price	Buy
246956	1g	$51.5	Buy
246956	5g	$64.5	Buy
B1100	5g	$52	Buy
B1100	25g	$156	Buy
70052	1g	$29	Buy

(S)-(-)-1,1'-Bi-2-naphthol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

Chiral ligand.

Uses

(S)-BINOL ligand in combination with titanium(IV) isopropoxide, forms (S)-(-)-BINOL-Ti complex, which is an effective chiral catalyst for:

asymmetric addition of alkynylzinc to unactivated ketones
enantioselective ring-opening reaction of meso-stilbene oxide and cyclohexene oxide with anilines
asymmetric aryl transfers from triaryl(tetrahydrofuran)aluminum reagents to a wide variety of ketones

It can also react with zirconium(IV) isopropoxide isopropanol complex to form a chiral Lewis acid catalyst for the facile enantioselective allylation of aldehydes by allyltributyltin.

Definition

ChEBI: (S)-(-)-1,1'-Bi-2-naphthol is a member of naphthols.

Purification Methods

Dissolve it in cold 2.5N NaOH, extract with CH2Cl2, and acidify with 5% HCl. Collect the white precipitate and recrystallise it from aqueous EtOH and dry it in a vacuum [Akimoto & Yamada Tetrahedron 27 5999 1971]. It is optically stable in dioxane-water (100o/24hours). Racemisation: 72% in 1.2N HCl at 100o/24hours and 68% in 0.67M KOH in BuOH at 118o/23hours [Kyba et al. J Am Chem Soc 95 2693 1973]. It has also been crystallised from *C6H6 (solubility is 1%) using Norite or aqueous EtOH after chromatography through silica gel, eluting with Me2CO/*C6H6. [Kyba et al. J Org Chem 42 4173 1977; see also Brussee & Jansen Tetrahedron Lett 24 3261 1983, Akimoto & Yamada Tetrahedron 27 5999 1971, Beilstein 6 IV 7020.]

(S)-(-)-1,1'-Bi-2-naphthol Preparation Products And Raw materials

Raw materials

Copper(II) chloride dihydrate Ethanol Toluene Phosphorus oxitrichloride Triethylamine

(R)-(+)-1-Phenylethylamine L-1-Phenylethylamine Iron chloride hexahydrate Tetrahydrofuran Benzene

Ethyl acetate Dichloromethane 2-Naphthol

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Preparation Products

(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL (S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (R)-(+)-2,2'-BIS(METHOXYMETHOXY)-1,1'-BINAPHTHYL

(S)-(-)-1,1'-Bi-2-naphthol Suppliers

Global( 491)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XINXIANG RUNYU MATERIAL CO., LTD.	+86-13592593621; +8613592593621	sales@runvmat.com	China	457	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8667	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13902	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58

Supplier	Advantage
XINXIANG RUNYU MATERIAL CO., LTD.	58
Shanghai UCHEM Inc.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from (S)-(-)-1,1'-Bi-2-naphthol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-22	(S)-(-)-1,1'-bi-2-naphthol 18531-99-2	US $12.00-193.00 / g	1g	0.98	25kg	Shanghai UCHEM Inc.
2025-12-23	(S)-(-)-1,1'-Bi-2,2'-naphthol 18531-99-2	US $0.00-0.00 / KG	1KG	99.99%	250KG	XINXIANG RUNYU MATERIAL CO., LTD.
2025-09-25	5-BROMO-2-FLUOROPHENYLACETIC ACID 18531-99-2	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

(S)-(-)-1,1'-bi-2-naphthol
18531-99-2
US $12.00-193.00 / g
0.98
Shanghai UCHEM Inc.

(S)-(-)-1,1'-Bi-2,2'-naphthol
18531-99-2
US $0.00-0.00 / KG
99.99%
XINXIANG RUNYU MATERIAL CO., LTD.

5-BROMO-2-FLUOROPHENYLACETIC ACID
18531-99-2
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

(S)-(-)-1,1'-Bi-2-naphthol Spectrum

(S)-(-)-1,1'-Bi-2-naphthol(18531-99-2)¹HNMR (S)-(-)-1,1'-Bi-2-naphthol(18531-99-2)¹HNMR (S)-(-)-1,1'-Bi-2-naphthol(18531-99-2)FT-IR (S)-(-)-1,1'-Bi-2-naphthol(18531-99-2)IR (S)-(-)-1,1'-Bi-2-naphthol(18531-99-2)Raman

18531-99-2((S)-(-)-1,1'-Bi-2-naphthol)Related Search:

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5,5',6,6',7,7',8,8'-Octahydro-bi-2-naphthol,(R)-(+)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-bi-2-naphthol,99% (S)-(-)-6,6'-Dibromo-1,1'-bi-2-naphthol (R)-(-)-6,6'-Dibromo-1,1'-bi-2-naphthol (-1,1'-Bi-2-Naphthol Deacetate (S)-1,1μ-Binaphthalene-2,2μ-diyl bis(trifluoromethanesulfonate), (S)-1,1μ-Bi(2-naphthol) bis(trifluoromethanesulfonate)

(S)-3,3'-Dibromo-1,1'-bi-2-naphthol (S)-(-)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-bi-2-naphthol (S)-6,6'-DIMETHYL-1,1'-BI-2-NAPHTHOL,6,6'-Dimethyl-1,1'-bi-2-naphthol

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(R)-(+)-2,2'-DIHYDROXY-1,1'-BINAPHTHYL (s)-(-)-1,1’-bi-2-nanphthol 1,1'-BI-2,2'-NAPHTHOLS [1,1']BINAPHTHALENYL-2,2'-DIOL (+/-)-1,1'-BINAPHTHALENE-2,2'-DIOL (S)-(-)-BINOL (S)-(-)-2,2'-Dihydroxy-1,1'-binaphthyl (S)-(-)-1,1''-BINAPHTHYL-2,2''-DIOL FOR SY (S)-1,1'-Binaphthalene-2,2'-diol, (S)-BINOL (S)-(-)-1,1'-Bi-2-naphthol S-(-)-2,2'-Dihydroxy-1,1'-binaphthyl (R,S)-BINOL AURORA KA-7212 BI-2-NAPHTHOL DI-B-NAPHTHOL (-)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL (+)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL (+/-)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL 2,2'-DIHYDROXY-1,1'-DINAPHTHYL 2,2'-DINAPHTHOL R(+)-1,1'-BINAPHTHALENE-2,2' (S)-(-)-1,1'-Bi-2-naphthol (S)-(-)-1,1'-Bi-2-naphthol, >=99.5% (S)-(-)-1,1'-Bi-2-phthol (S)-(-)-1,1'-Binaphthyl-2,2'-diol for synthesis (R)-(+)-2,2'-DIHYDROXY-1,1-BINAPHTHYL (R)-(+)-1,1'-BI(2,2'-NAPHTHOL) (R)-(+)-1,1'-BINAPHTHYL-2,2'-DIOL R(+)-1,1'-BINAPHTHALENE-2,2'-DIOL (R)-[1,1]-BINAPHTHALENYL-2,2'-DIOL (R)-(+)-1,1'-BIS(2-NAPHTHOL) (S)-(-)-BINOL S-(-)-2,2'-DIHYDROXY-1,1'-DINAPHTHYL (S)-(-)-2,2'-DIHYDROXY-1,1'-BINAPHTHYL (S)-(-)-2,2'-DIHYDROXY-1,1-BINAPHTHYL (S)-[1,1]-BINAPHTHALENYL-2,2'-DIOL (S)-(-)-1,1'-BINAPHTHYL-2,2'-DIOL S(-)-1,1'-BINAPHTHALENE-2,2'-DIOL (S)-(-)-1,1'-BI(2,2'-NAPHTHOL) (S)-(+)-1,1'-BI-2-NAPHTHOL (S)-1,1'-BI-2-NAPHTHOL (S)-1,1-BI-2-NAPHTHOL 1,1'-BINAPHTHYL-2,2'-DIOL AKOS 90560 S-(-)-1,1'-Bi-2-naphthol,99%(S)-BINOL 1,1-Binaphthalene-2,2-diol, (1S)- S-BINOL/S-(-)-1.1''-BINAPHTHYL-2.2''-DIOL (S)-(-)-1,1'-Bi-2-naphtol S-(-)-2,2''-DIHYDROXY-1,1''-DINAPHTHYL (S)-BINOL (S)-1,1 -BI-2-NAPHTHOL ***REVERSE*** S-1,1-Bi-2-Naphtho (S)-[1,1']-Binaphth-2-ol, (S)-BINOL (-)-2,2μ-Dihydroxy-1,1μ-dinaphthyl, (S)-(-)-1,1μ-Binaphthalene-2,2μ-diol, (S)-BINOL [aS,(-)]-1,1'-Binaphthalene-2,2'-diol [aS,(-)]-2,2'-Dihydroxy-1,1'-binaphthalene [aS,(-)]-Dinaphthol (1S)-1,1'-Binaphthalene-2,2'-diol, (S)-BINOL (S)-(-)-1,1'-Bi-2-naphthol,99% （S）-(-)-1_Bi-3-naphthol (S)-(-)-1,1'-Bi-2-na