2,6-Difluorobenzoic acid
- CAS No.
- 385-00-2
- Chemical Name:
- 2,6-Difluorobenzoic acid
- Synonyms
- 2,6-Difluorobenzoic;NSC 126584;2.6-Difluorobe;AKOS BBS-00003807;RARECHEM AL BO 0020;Difluorobenzoicacid;Difluorobenzoic aci;6-Difluorobenzoic acid;2,6-Difuorobenzoic acid;2,6-difluorobonzoic acid
- CBNumber:
- CB3384505
- Molecular Formula:
- C7H4F2O2
- Molecular Weight:
- 158.1
- MDL Number:
- MFCD00002411
- MOL File:
- 385-00-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 157-161 °C (lit.) |
|---|---|
| Boiling point | 72-77°C 13mm |
| Density | 1.3486 (estimate) |
| Flash point | 72-77°C/13mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 2.34±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Water Solubility | soluble |
| BRN | 973774 |
| InChI | 1S/C7H4F2O2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11) |
| InChIKey | ONOTYLMNTZNAQZ-UHFFFAOYSA-N |
| SMILES | OC(=O)c1c(F)cccc1F |
| CAS DataBase Reference | 385-00-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 95B9M9KUY5 |
| NIST Chemistry Reference | 2,6-Difluorobenzoic acid(385-00-2) |
| EPA Substance Registry System | 2,6-Difluorobenzoic acid (385-00-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-37/38-36 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG8559000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,6-Difluorobenzoic acid price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 190039 | 2,6-Difluorobenzoic acid 98% | 385-00-2 | 5g | $54.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 190039 | 2,6-Difluorobenzoic acid 98% | 385-00-2 | 25g | $123 | 2026-04-30 | Buy |
| TCI Chemical | D1629 | 2,6-Difluorobenzoic Acid >98.0%(T) | 385-00-2 | 25g | $78 | 2026-04-30 | Buy |
| TRC | TRC-D445475-25G | 2,6-Difluorobenzoic Acid | 385-00-2 | 25g | $154 | 2026-06-03 | Buy |
| TRC | TRC-D445475-250G | 2,6-Difluorobenzoic Acid | 385-00-2 | 250g | $529 | 2026-06-03 | Buy |
2,6-Difluorobenzoic acid Chemical Properties, Uses, Production
Preparation
The synthesis process of 2,6-difluorobenzoic acid (DFBA) involves using 2,6-dichlorobenzonitrile (DCBN) and potassium fluoride as raw materials, and N,N-dimethylamide (DMF) as solvent. The intermediate 2,6-difluorobenzonitrile is synthesized by fluorination under the catalysis of polyether catalyst A. The intermediate is then hydrolyzed under alkaline conditions to obtain 2,6-difluorobenzoic acid. Experimental results show that the optimal reaction conditions are: a mass concentration of 2,6-dichlorobenzonitrile in N,N-dimethylamide of 0-38 g/mL, a potassium fluoride concentration 2.3-2.4 times that of 2,6-dichlorobenzonitrile, a reaction time of 10 h, and a maximum yield of 93.5%. In the synthesis of 2,6-difluorobenzoic acid, using 20% NaOH as the medium and a reaction time of 9 h, the yield is ≥92%. This process offers high yield, low waste emissions, and cost savings, making it a promising candidate for industrial application.
Chemical Properties
White to light yellow crystal powder
Uses
2,6-Difluorobenzoic acid has been used in the synthesis of 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide and methyl 2,6-difluorobenzoate.
General Description
2,6-Difluorobenzoic acid is the major degradation product of diflubenzuron.
Toxics Screening Level
Due to a lack of available toxicity information the ITSL is being set at the default value of 0.1 μg/m3 with annual averaging, based on R232(1)(i).
2,6-Difluorobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Yuanhua New Materials Co., Ltd | 19015480862; 19015480862 | 3689187891@qq.com | China | 254 | 58 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Baoding Bink New Materials Co., Ltd. | 17531153977 | allison@yan-xi.com | China | 315 | 58 |
| Zibo Run Hang Seng material Technology Co., LTD | 13561657928 13561657928 | 2388773670@qq.com | China | 294 | 58 |
| Ningtai Chemical (Shandong) Co., Ltd | 15314216173 | 2045904044@qq.com | China | 149 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 2,6-Difluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 2,6-Difluorobenzoic acid
385-00-2
|
$85.00 | 1KG | 99% | 300MT/year | Speranza Chemical Co., Ltd. | |
 |
2026-09-17 | 2,6-Difluorobenzoic acid
385-00-2
|
1KG | 99%min GC | 1000kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 2,6-Difluorobenzoic acid
385-00-2
|
$1.10-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd |
-
- 2,6-Difluorobenzoic acid
385-00-2
- $85.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 2,6-Difluorobenzoic acid
385-00-2
- $0.00
- 99%min GC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,6-Difluorobenzoic acid
385-00-2
- $1.10-32.00
- 99%
- Henan Fengda Chemical Co., Ltd
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