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(R)-(-)-IBUPROFEN

(R)-(-)-IBUPROFEN Structure
(R)-(-)-IBUPROFEN structure
CAS No.
51146-57-7
Chemical Name:
(R)-(-)-IBUPROFEN
Synonyms
(R)-IBUPROFEN;(-)-Ibuprofen;(R)-2-(4-Isobutylphenyl)propanoic acid;l-Ibuprofen;levibuprofen;(-)-Ibuprophen;2-Yl)carbamate;(R)-(-)-Ibupr en;(R)-(-)-IBUPROFEN;Ibuprofen (R)-Isomer
CBNumber:
CB3393273
Molecular Formula:
C13H18O2
Molecular Weight:
206.29
MDL Number:
MFCD00069290
MOL File:
51146-57-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-30 11:39:11
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(R)-(-)-IBUPROFEN Properties

Melting point 41-42°C
Boiling point 305.14°C (rough estimate)
Density 1.0176 (rough estimate)
refractive index 1.5290 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form White crystalline powder.
pka 4.41±0.10(Predicted)
color Colourless to Pale Beige Oil
Water Solubility 369.3mg/L(25 ºC)
FDA UNII 99W8H60N62

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  24/25
HS Code  29155090

(R)-(-)-IBUPROFEN price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical I1222 (R)-(-)-Ibuprofen min. 98.0 % 51146-57-7 200MG $149 2026-04-30 Buy
TCI Chemical I1222 (R)-(-)-Ibuprofen min. 98.0 % 51146-57-7 1G $447 2026-04-30 Buy
Cayman Chemical 16794 (R)-Ibuprofen ≥98% 51146-57-7 100mg $85 2026-04-30 Buy
Cayman Chemical 16794 (R)-Ibuprofen ≥98% 51146-57-7 250mg $195 2026-04-30 Buy
Cayman Chemical 16794 (R)-Ibuprofen ≥98% 51146-57-7 500mg $367 2026-04-30 Buy
Product number Packaging Price Buy
I1222 200MG $149 Buy
I1222 1G $447 Buy
16794 100mg $85 Buy
16794 250mg $195 Buy
16794 500mg $367 Buy

(R)-(-)-IBUPROFEN Chemical Properties, Uses, Production

Description

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.

Chemical Properties

White Crystalline Solid

Uses

A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.

Definition

ChEBI: Levibuprofen is an ibuprofen. It is an enantiomer of a dexibuprofen.

Purification Methods

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

References

[1] PHILLIP JEFFREY. The Site of Inversion of R(–)-Ibuprofen: Studies Using Rat In-situ Isolated Perfused Intestine/liver Preparations[J]. Journal of Pharmacy and Pharmacology, 1991, 43 10: 715-720. DOI: 10.1111/j.2042-7158.1991.tb03464.x

(R)-(-)-IBUPROFEN Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-IBUPROFEN Suppliers

Global Suppliers ( 176)
Supplier Tel Email Country ProdList Advantage
Shanghai RC biotechnology Ltd. 021-18217521994; 18217521994 1809424504@qq.com China 152 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@163.com China 280 58
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
Shanghai RC biotechnology Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Energy Chemical 61
Jia Xing Isenchem Co.,Ltd 66
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 58
Chemsky（shanghai）International Co.,Ltd. 50

View Latest Price from (R)-(-)-IBUPROFEN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(-)-Ibuprofen pictures 2026-08-30 (R)-(-)-Ibuprofen
51146-57-7
 $35.00-86.00 99.86% 10g TargetMol Chemicals Inc.
(R)-(-)-IBUPROFEN USP/EP/BP pictures 2026-08-20 (R)-(-)-IBUPROFEN USP/EP/BP
51146-57-7
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
(R)-(-)-IBUPROFEN pictures 2019-08-02 (R)-(-)-IBUPROFEN
51146-57-7
 $1.00 1KG 95-99% 500kg/month Career Henan Chemical Co

(R)-(-)-IBUPROFEN Spectrum

(R)-(-)-IBUPROFEN(51146-57-7)1HNMR

51146-57-7 ((R)-(-)-IBUPROFEN) Related Search:

IBUPROFEN IMPURITY D,IBUPROFEN IMP D IBUPROFEN IMPURITY J IBUPROFEN IMPURITY E,IBUPROFEN IMP E 1-Hydroxyibuprofen (S)-(+)-Ibuprofen
2-[4-(2-Methylpropyl)phenyl] ethanol 6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one 4-(2-Methylpropyl)benzeneethanol Ibuprofen EP Impurity I p-Isobutylstyrene
rac a-Hydroxy Ibuprofen trans-Ibuprofen IMpurity G Ibuprofen (2RS)-2-(4-n-Propylphenyl)propanoic acid 3-(4-Isobutyl-phenyl)-propionic acid
IBUPROFEN IMP P Ibuprofen ethyl IBUPROFEN IMP F2,Ibuprofen methyl

1of4

(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID (R)-(-)-IBUPROFEN (-)-Ibuprophen (R)-2-(4-Isobutylphenyl)propanoic acid Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)- l-Ibuprofen R-(-)-p-Isobutylhydratropic acid Ibuprofen Impurity 20((R)-Isomer) (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)- (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid levibuprofen (R)-(-)-Ibupr en (R)-(-)-Ibuprofen ((R)-Ibuprofen) (R)-(-)-ibuprofen reference substance Ibuprofen (R)-Isomer (R)-(-)-IBUPROFEN USP/EP/BP (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What are the applications of (R)-Ibuprofen 5-Triiodo-L-thyronine sodium 2-Yl)carbamate (αR)?-α-?Methyl-?4-?(2-?methylpropyl)?-benzeneacetic Acid (R)-(-)-Ibuprofen, 10 mM in DMSO (2R)-2-(4-isobutylphenyl)propanoic acid - [K86867] (-)-Ibuprofen (R)-IBUPROFEN (-)-2(R)-(4-Isobutylphenyl)propionic acid 51146-57-7 1146-57-7 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Chiral Reagents