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(R)-(-)-IBUPROFEN

(R)-(-)-IBUPROFEN Structure
(R)-(-)-IBUPROFEN structure
CAS No.
51146-57-7
Chemical Name:
(R)-(-)-IBUPROFEN
Synonyms
(R)-IBUPROFEN;(R)-2-(4-Isobutylphenyl)propanoic acid;l-Ibuprofen;levibuprofen;(-)-Ibuprofen;(-)-Ibuprophen;2-Yl)carbamate;(R)-(-)-Ibupr en;(R)-(-)-IBUPROFEN;Ibuprofen (R)-Isomer
CBNumber:
CB3393273
Molecular Formula:
C13H18O2
Molecular Weight:
206.29
MDL Number:
MFCD00069290
MOL File:
51146-57-7.mol
Last updated:2025-08-30 21:37:50
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(R)-(-)-IBUPROFEN Properties

Melting point 41-42°C
Boiling point 305.14°C (rough estimate)
Density 1.0176 (rough estimate)
refractive index 1.5290 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form White crystalline powder.
pka 4.41±0.10(Predicted)
color Colourless to Pale Beige Oil
Water Solubility 369.3mg/L(25 ºC)
FDA UNII 99W8H60N62

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  24/25
HS Code  29155090

(R)-(-)-IBUPROFEN price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical I1222 (R)-(-)-Ibuprofen min. 98.0 % 51146-57-7 200MG $149 2025-07-31 Buy
TCI Chemical I1222 (R)-(-)-Ibuprofen min. 98.0 % 51146-57-7 1G $447 2025-07-31 Buy
Cayman Chemical 16794 (R)-Ibuprofen ≥98% 51146-57-7 100mg $77 2024-03-01 Buy
Cayman Chemical 16794 (R)-Ibuprofen ≥98% 51146-57-7 250mg $177 2024-03-01 Buy
Cayman Chemical 16794 (R)-Ibuprofen ≥98% 51146-57-7 500mg $333 2024-03-01 Buy
Product number Packaging Price Buy
I1222 200MG $149 Buy
I1222 1G $447 Buy
16794 100mg $77 Buy
16794 250mg $177 Buy
16794 500mg $333 Buy

(R)-(-)-IBUPROFEN Chemical Properties,Uses,Production

Description

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.

Chemical Properties

White Crystalline Solid

Uses

A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.

Definition

ChEBI: Levibuprofen is an ibuprofen. It is an enantiomer of a dexibuprofen.

Purification Methods

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

References

[1] PHILLIP JEFFREY. The Site of Inversion of R(–)-Ibuprofen: Studies Using Rat In-situ Isolated Perfused Intestine/liver Preparations[J]. Journal of Pharmacy and Pharmacology, 1991, 43 10: 715-720. DOI: 10.1111/j.2042-7158.1991.tb03464.x

(R)-(-)-IBUPROFEN Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-IBUPROFEN Suppliers

Global( 176)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32430 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14447 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 21102 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15172 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Win-Win chemical CO., Limited 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58

View Lastest Price from (R)-(-)-IBUPROFEN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(-)-Ibuprofen pictures 2025-08-30 (R)-(-)-Ibuprofen
51146-57-7
 US $35.00-86.00 / mg 99.86% 10g TargetMol Chemicals Inc.
(R)-(-)-IBUPROFEN USP/EP/BP pictures 2021-06-09 (R)-(-)-IBUPROFEN USP/EP/BP
51146-57-7
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
(R)-(-)-IBUPROFEN pictures 2019-08-02 (R)-(-)-IBUPROFEN
51146-57-7
 US $1.00 / KG 1KG 95-99% 500kg/month Career Henan Chemical Co

(R)-(-)-IBUPROFEN Spectrum

(R)-(-)-IBUPROFEN(51146-57-7)1HNMR

51146-57-7((R)-(-)-IBUPROFEN)Related Search:

IBUPROFEN IMPURITY D,IBUPROFEN IMP D IBUPROFEN IMPURITY J α-Methyl-4-(isobutyl)phenylacetic acid, Ibuprofen,Ibuprofen (FDA),R,S-Ibuprofen,rac Ibuprofen,IBUPROFEN,(+/-)-IBUPROFEN IBUPROFEN IMPURITY E,IBUPROFEN IMP E 1-Hydroxyibuprofen
(S)-(+)-Ibuprofen 2-[4-(2-Methylpropyl)phenyl] ethanol 6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one 4-(2-Methylpropyl)benzeneethanol Ibuprofen EP Impurity I
3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID p-Isobutylstyrene rac a-Hydroxy Ibuprofen (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID trans-Ibuprofen IMpurity G
IBUPROFEN IMPURITY C,IBUPROFEN IMP C IBUPROFEN IMP N IBUPROFEN IMP F2,Ibuprofen methyl

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(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID (R)-(-)-IBUPROFEN (R)-IBUPROFEN (-)-Ibuprophen (R)-2-(4-Isobutylphenyl)propanoic acid Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)- l-Ibuprofen R-(-)-p-Isobutylhydratropic acid Ibuprofen Impurity 20((R)-Isomer) (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)- (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid levibuprofen (R)-(-)-Ibupr en (R)-(-)-Ibuprofen ((R)-Ibuprofen) (R)-(-)-ibuprofen reference substance Ibuprofen (R)-Isomer (R)-(-)-IBUPROFEN USP/EP/BP (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What are the applications of (R)-Ibuprofen 5-Triiodo-L-thyronine sodium (-)-Ibuprofen 2-Yl)carbamate (αR)?-α-?Methyl-?4-?(2-?methylpropyl)?-benzeneacetic Acid (R)-(-)-Ibuprofen, 10 mM in DMSO (2R)-2-(4-isobutylphenyl)propanoic acid - [K86867] 51146-57-7 1146-57-7 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Chiral Reagents