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(S)-(+)-Ibuprofen

(S)-(+)-Ibuprofen structure

CAS No.: 51146-56-6

Chemical Name:: (S)-(+)-Ibuprofen

Synonyms: DEXIBUPROFEN;(S)-IBUPROFEN;(S)-2-(4-Isobutylphenyl)propanoic acid;Seractil;Ramelteon-7;d-Ibuprofen;exibuprofen;Deibuprofen;Dextroprofen;(+)-Ibuprofen

CBNumber:: CB0699655

Molecular Formula:: C13H18O2

Molecular Weight:: 206.28

MDL Number:: MFCD00069289

MOL File:: 51146-56-6.mol

MSDS File:: SDS

Last updated:2026-04-14 09:55:04

Product description	Number	Pack Size	Price
(S)-(+)-Ibuprofen ReagentPlus , 99%	375160	1g	$64
(S)-(+)-Ibuprofen ReagentPlus , 99%	375160	5g	$129
(S)-(+)-2-(4-Isobutylphenyl)propionic Acid >98.0%(GC)(T)	I0549	1g	$17
(S)-(+)-2-(4-Isobutylphenyl)propionic Acid >98.0%(GC)(T)	I0549	5g	$39
(S)-Ibuprofen ≥98%	16793	1g	$43
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(S)-(+)-Ibuprofen Properties

Melting point	49-53 °C(lit.)
alpha	57 º (c=2, EtOH)
Boiling point	285.14°C (rough estimate)
Density	1.0364 (rough estimate)
refractive index	59 ° (C=2, EtOH)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL
pka	4.41±0.10(Predicted)
form	solid
color	white
optical activity	[α]20/D +59°, c = 2 in ethanol
Water Solubility	insoluble
BRN	3590022
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
InChIKey	HEFNNWSXXWATRW-JTQLQIEISA-N
SMILES	CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O
CAS DataBase Reference	51146-56-6(CAS DataBase Reference)
FDA UNII	671DKG7P5S
ATC code	M01AE14
UNSPSC Code	12352002
NACRES	NA.22

Pharmacokinetic data

Protein binding	>99%
Excreted unchanged in urine	82 (mainly as inactive metabolites)
Volume of distribution	10-11 Litres
Biological half-life	1.6-1.9 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

63-22

Safety Statements

45-36/37

WGK Germany

HS Code

29163990

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

(S)-(+)-Ibuprofen price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	375160	(S)-(+)-Ibuprofen ReagentPlus , 99%	51146-56-6	1g	$64	2026-03-19	Buy
Sigma-Aldrich	375160	(S)-(+)-Ibuprofen ReagentPlus , 99%	51146-56-6	5g	$129	2026-03-19	Buy
TCI Chemical	I0549	(S)-(+)-2-(4-Isobutylphenyl)propionic Acid >98.0%(GC)(T)	51146-56-6	1g	$17	2026-03-19	Buy
TCI Chemical	I0549	(S)-(+)-2-(4-Isobutylphenyl)propionic Acid >98.0%(GC)(T)	51146-56-6	5g	$39	2026-03-19	Buy
Cayman Chemical	16793	(S)-Ibuprofen ≥98%	51146-56-6	1g	$43	2024-03-01	Buy

Product number	Packaging	Price	Buy
375160	1g	$64	Buy
375160	5g	$129	Buy
I0549	1g	$17	Buy
I0549	5g	$39	Buy
16793	1g	$43	Buy

(S)-(+)-Ibuprofen Chemical Properties,Uses,Production

Description

Dexibuprofen, the S-(+)-isomer of the widely used NSAID agent ibuprofen, was launched in Austria for the treatment of rheumatoid arthritis. While the racemic compound is commonly used clinically, the antiinflammatory activity is mediated via the S-isomer by inhibition of prostaglandin synthesis. It has also been demonstrated that the R-isomer is converted to the Santipode in vivo via a CoA thioester intermediate. Since CoA plays a pivotal role in intermediary metabolism and maintenance of the [acyl-CoA], generation of R-ibuprofen-CoA competitively inhibits many CoA-dependent reactions, which consequently produces perturbations of hepatocyte Intermediary metabolism and mitocondrial function. Pure S-ibuprofen usage, therefore, is preferred allowing a reduction in dosage level and an improved side effect profile.

Description

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC₅₀s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC₅₀s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB₄ generation by stimulated neutrophils (IC₅₀ values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.

Chemical Properties

Colourless, Crystalline Solid

Originator

Gebro Broschek (Austria)

Uses

A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer

Uses

sedative

Uses

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.

Definition

ChEBI: Dexibuprofen is an ibuprofen. It has a role as a non-narcotic analgesic and a non-steroidal anti-inflammatory drug. It is an enantiomer of a levibuprofen.

brand name

Seractil

General Description

(S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form.

Biological Activity

Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC 50 values are 12 and 80 μ M respectively). Active isomer of ibuprofen.

Clinical Use

NSAID and analgesic

Drug interactions

Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect, increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possibly increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir
Ciclosporin: may potentiate nephrotoxicity
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity

Metabolism

Dexibuprofen is the S(+)-enantiomer of ibuprofen. After metabolic transformation in the liver (hydroxylation and carboxylation), the pharmacologically inactive metabolites are completely excreted, mainly by the kidneys (90%), but also in the bile.

Purification Methods

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

References

[1] JIM BARNETT . Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system[J]. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1994, 1209 1: Pages 130-139. DOI: 10.1016/0167-4838(94)90148-1
[2] NICOLE SCHEUREN. Modulation of transcription factor NF-κB by enantiomers of the nonsteroidal drug ibuprofen[J]. British Journal of Pharmacology, 2009, 123 4: 645-652. DOI: 10.1038/sj.bjp.0701652
[3] M. VILLANUEVA. Equipotent inhibition by R(), S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro.[J]. British journal of clinical pharmacology, 1993, 35 3: 235-242. DOI: 10.1111/j.1365-2125.1993.tb05690.x
[4] A BONABELLO. Dexibuprofen (S+-isomer ibuprofen) reduces gastric damage and improves analgesic and antiinflammatory effects in rodents.[J]. Anesthesia and analgesia, 2003, 97 2: 402-408. DOI: 10.1213/01.ane.0000073349.04610.42

(S)-(+)-Ibuprofen Preparation Products And Raw materials

Raw materials

1-DEOXY-1-(OCTYLAMINO)-D-GLUCITOL (R)-(+)-4-Isopropyl-2-oxazolidinone

Preparation Products

(S)-(+)-Ibuprofen Suppliers

Global( 397)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	672	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Wuhan JiyunZen Tech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Xiamen AmoyChem Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from (S)-(+)-Ibuprofen manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	(S)-(+)-Ibuprofen 51146-56-6	US $0.00 / Kg/Drum	1KG	98.5%-101%	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-14	(S)-(+)-Ibuprofen 51146-56-6	US $31.00 / g		99.51%	10g	TargetMol Chemicals Inc.
2026-04-14	(S)-(+)-Ibuprofen 51146-56-6	US $31.00 / g		99.51%	10g	TargetMol Chemicals Inc.

(S)-(+)-Ibuprofen
51146-56-6
US $0.00 / Kg/Drum
98.5%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

(S)-(+)-Ibuprofen
51146-56-6
US $31.00 / g
99.51%
TargetMol Chemicals Inc.

(S)-(+)-Ibuprofen
51146-56-6
US $31.00 / g
99.51%
TargetMol Chemicals Inc.

(S)-(+)-Ibuprofen Spectrum

(S)-(+)-Ibuprofen(51146-56-6)MS (S)-(+)-Ibuprofen(51146-56-6)¹HNMR (S)-(+)-Ibuprofen(51146-56-6)¹³CNMR (S)-(+)-Ibuprofen(51146-56-6)IR1 (S)-(+)-Ibuprofen(51146-56-6)IR2 (S)-(+)-Ibuprofen(51146-56-6)Raman

51146-56-6((S)-(+)-Ibuprofen )Related Search:

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DEXIBUPROFEN (S)-(+)-2-(4-ISOBUTYLPHENYL)PROPIONIC ACID (S)-(+)-4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID (S)-(+)-IBUPROFEN (S)-IBUPROFEN (2s)-2-[4-(2-methylpropyl)phenyl]propionic acid (S)-(+)-Ibuprofen ReagentPlus(R), 99% (S)-2-(4-Isobutylphenyl)propanoic acid, 95+% (S)-((addition))-Ibuprofen (S)-(+)-4-Isobutyl-a-methylphenylacetic acid (S)-(+)-Ibuprofen, 98.5%, COX inhibitor Ibuprofen Impurity 21((S)-Isomer) RaMelteon iMpurity G Ramelteon-7 Ramelteon Imputiry G (S)-( )-Ibuprofen ((S)-Ibuprofen) S(+)-IBUPROFEN ACTIVE ISOMER OF IBUP (+)-(S)-p-Isobutylhydratropic acid (S)-(+)-4-Isobutyl-α-methylphenylacetic acid (S)-2-(4-Isobutylphenyl)propanoic acid (S)-2-(p-Isobutylphenyl)propionic acid Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (S)- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αS)- d-Ibuprofen Seractil S(+)-IBUPROFENE [αS,(+)]-α-Methyl-4-(2-methylpropyl)benzeneacetic acid (S)-(+)-Ibuprofen,99% s(+)-2-(4-isobutylphenyl)propionic (aS)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid (S)-(+)-2-(4-Isobutylphenyl)propionic acid, (S)-(+)-4-Isobutyl-α-methylphenylacetic acid (S)-(+)-Ibuprofen, 99% 1GR (S)-(+)-Ibuprofen (S)-(+)-4-Isobutyl-alpha-methylphenylacetic Acid (S)-(+)-Ibuprofen, 98.5% (S)-(+)-ibuprofen reference substance (S)-(+)-2-(4-Isobutylphenyl)propionicAcid> (S)-2-(4-IsobutyL Ibuprofen (S)-Isomer (S)-(+)-IbuprofenALPHA-METHYLPHENYLACETICACID Dex-ibuprofen (S-ibuprofen) (S)-(+)-IbuprofenQ: What is (S)-(+)-Ibuprofen Q: What is the CAS Number of (S)-(+)-Ibuprofen Q: What is the storage condition of (S)-(+)-Ibuprofen Dextral ibuprofen Dexibuprofen (free acid)，(S)-(+)-Ibuprofen exibuprofen Dextroibuprofen (+)-Ibuprofen Deibuprofen Dextrobuprofen Dextroprofen (S)-(+)-Ibuprofen, Non-selective COX inhibitor (S)-(+)-Ibuprofen, 10 mM in DMSO (S)-(+)-Ibuprofen 51146-56-6 511406-56-6 Cyclooxygenase Inhibitors Enzymes, Inhibitors, and Substrates Organic Building Blocks Biochemicals and Reagents