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ChemicalBook >> CAS DataBase List >>(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Structure
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone structure
CAS No.
1421502-62-6
Chemical Name:
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone
Synonyms
PF 6263276;PF06263276,PF 06263276;PF-06263276 (PF 6263276);PF-06263276 >=98% (HPLC);(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone;2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone;Methanone, [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(1-piperidinyl)-2-pyrazinyl]-
CBNumber:
CB33953058
Molecular Formula:
C31H31FN8O2
Molecular Weight:
566.63
MDL Number:
MFCD30718580
MOL File:
1421502-62-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:01
Request For Quotation

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Properties

Boiling point 921.1±65.0 °C(Predicted)
Density 1.394±0.06 g/cm3(Predicted)
storage temp. room temp
solubility Soluble in DMSO
form powder
pka 8.54±0.25(Predicted)
color white to beige
InChIKey XDJGNPSZQSWJCV-UHFFFAOYSA-N
SMILES FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CCN(C(C6=CN=C(N7CCCCC7)C=N6)=O)C5)N4)=C3C=C2)=C1
FDA UNII 86YZ7HCC8V
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0324 PF-06263276 ≥98% (HPLC) 1421502-62-6 5mg $108 2024-03-01 Buy
Sigma-Aldrich PZ0324 PF-06263276 ≥98% (HPLC) 1421502-62-6 25mg $435 2024-03-01 Buy
Biosynth WGC50262 PF-06263276 1421502-62-6 50mg $1298 2026-06-05 Buy
ChemScene CS-0020732 PF-06263276 98.26% 1421502-62-6 5mg $143 2026-06-04 Buy
ChemScene CS-0020732 PF-06263276 98.26% 1421502-62-6 10mg $238 2026-06-04 Buy
Product number Packaging Price Buy
PZ0324 5mg $108 Buy
PZ0324 25mg $435 Buy
WGC50262 50mg $1298 Buy
CS-0020732 5mg $143 Buy
CS-0020732 10mg $238 Buy

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Chemical Properties, Uses, Production

Uses

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively. PF-06263276 inhibits pSTAT3 and TYK2 pathway. PF-06263276 has a protective effect against ear skin inflammation[1].

Biological Activity

PF-06263276 is an inhibitor of the Janus kinase (JAK) enzymes 1, 2, 3 and tyrosine kinase 2 (TYK2). PF-06263276 has been investigated for the treatment of psoriasis.

in vivo

PF-06263276 (0.3-100 μg/animal; i.t.) can dose-dependently inhibit the increase of lung pSTAT3 in the pharmacodynamic model of IL-6-induced lung pSTAT3 response in mice, with an ED50 of approximately 3 μg/animal[1].
PF-06263276 (4% solution; topical administration; multiple times; 11 days) can significantly reduce ear swelling by 48% in the IL-23-induced mouse ear skin inflammation model and inhibit the JAK2/TYK2 pathway[1].

IC 50

JAK1: 2.2 nM (IC50); JAK2: 23.1 nM (IC50); JAK3: 59.9 nM (IC50); Tyk2: 29.7 nM (IC50)

References

[1] Jones P, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786. DOI:10.1021/acs.jmedchem.6b01634

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Suppliers

Global Suppliers ( 22)
Supplier Tel Email Country ProdList Advantage
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 2223443625@qq.com China 7998 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29982 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 4000862158 18117107507 vip@med-life.cn China 4999 58
Supplier Advantage
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Hubei Kele Fine Chemical Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58

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PF-06263276 pictures 2026-07-27 PF-06263276
1421502-62-6
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    1421502-62-6
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1421502-62-6 ((2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone) Related Search:

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PF 6263276 PF-06263276 (PF 6263276) Methanone, [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(1-piperidinyl)-2-pyrazinyl]- PF-06263276 >=98% (HPLC) PF06263276,PF 06263276 2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone (2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone 1421502-62-6 C31H31FN8O2