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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Structure
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone structure
CAS No.
43229-01-2
Chemical Name:
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Synonyms
1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one;1-(4-(BenzyL;)-2-bromoethanone;Formoterol Bromide;oxy)-3-nitrophenyL;Formoterol Impurity 23;Formoterol Impurity 31;Formoterol Intermediate;(phenylmethoxy)phenyl]-ethanone;3-Nitro-4-benzyloxy-2-bromophenone
CBNumber:
CB3396148
Molecular Formula:
C15H12BrNO4
Molecular Weight:
350.16
MDL Number:
MFCD06797599
MOL File:
43229-01-2.mol
Last updated:2025-09-09 10:27:52
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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Properties

Melting point 135-137 °C(Solv: ethanol (64-17-5))
Boiling point 465.2±35.0 °C(Predicted)
Density 1.517±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in Methylene chloride, sparingly soluble in ethyl acetate, insoluble in water
form Solid
color Pale yellow to cream coloured crystalline powder
InChI InChI=1S/C15H12BrNO4/c16-9-14(18)12-6-7-15(13(8-12)17(19)20)21-10-11-4-2-1-3-5-11/h1-8H,9-10H2
InChIKey PBAAKBQGBSUCTG-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=C(OCC2=CC=CC=C2)C([N+]([O-])=O)=C1)CBr
CAS DataBase Reference 43229-01-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302 - H315 - H319 - H335
Precautionary statements  P261 - P305+P351+P338

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B287165 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 1g $50 2021-12-16 Buy
AK Scientific J95552 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 5g $240 2021-12-16 Buy
Matrix Scientific 090612 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 95+% 43229-01-2 250mg $243 2021-12-16 Buy
Biosynth Carbosynth FB61706 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 10g $400 2021-12-16 Buy
Biosynth Carbosynth FB61706 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 25g $500 2021-12-16 Buy
Product number Packaging Price Buy
B287165 1g $50 Buy
J95552 5g $240 Buy
090612 250mg $243 Buy
FB61706 10g $400 Buy
FB61706 25g $500 Buy

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Chemical Properties,Uses,Production

Uses

1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone, can be used as an intermediate in the synthesis of Arformoterol Tartrate (A767505), which is a derivative of Arformoterol, a long acting beta-adrenoceptor agonist drug indicated for the treatment of chronic obstructive pulmonary disease (COPD).

Synthesis

4-Benzyloxy-3-nitroacetophenone

14347-05-8

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

43229-01-2

Step 2: 200 g of 4-benzyloxy-3-nitroacetophenone (Intermediate 1) was dissolved in 1000 mL of dichloromethane and 277 g of trimethylphenylammonium tribromide was added. The reaction mixture was heated to 300 °C and kept for 4 hours. After completion of the reaction, the residual liquid was poured into water, filtered, washed and dried to give 253 g of 3'-nitro-4'-benzyloxy-2-bromoacetophenone in 98% yield.

References

[1] Patent: CN108358791, 2018, A. Location in patent: Paragraph 0016; 0020
[2] Canadian Journal of Chemistry, 2011, vol. 89, # 3, p. 364 - 384
[3] Chirality, 2010, vol. 22, # 2, p. 206 - 211
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 249 - 253
[5] Tetrahedron Asymmetry, 2000, vol. 11, # 13, p. 2705 - 2717

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

4-Benzyloxy-3-nitroacetophenone Dichloromethane Phenyltrimethylammonium bromide

Preparation Products

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Suppliers

Global( 283)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12398 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29733 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 12933 58
Taizhou Tianhong Biochemistry Technology Co., Ltd. 		0523-86132544 sales@thbiochem.com CHINA 305 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Taizhou Tianhong Biochemistry Technology Co., Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

View Lastest Price from 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone pictures 2025-09-08 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
43229-01-2
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone pictures 2025-07-25 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
43229-01-2
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone pictures 2025-06-24 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
43229-01-2
 US $10.00 / KG 100KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Spectrum

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone(43229-01-2)1HNMR

43229-01-2(2-Bromo-4'-Benzyloxy-3'-nitroacetophenone)Related Search:

PHENYL VALERATE 4-Nitrobenzyl chloroformate 4-Nitrobenzyl alcohol 4'-Bromoacetophenone L-PICEIN
4-Nitroacetophenone 2-Bromoacetophenone 4-Methoxybenzylchloride 3-Nitroacetophenone PHENYL RESIN
Phenylacetic acid 3-Nitrophenacylbromide 4-Benzyloxy-3-nitroacetophenone 4-Nitrobenzyl chloride 3-Bromonitrobenzene
NITROGEN DIOXIDE 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 2'-Bromoacetophenone

1of4

ALPHA-BROMO 4-BENZYLOXY-3-NITRO ACETOPHENONE 1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one Formoterol Bromide 2-Bromo-1-[3-Nitro-4-(Phenylmethoxy)Phenyl]Ethanone 2-Bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-ethanone 3-BroMo-1-[3-Nitro-4-(PhenylMethoxy)phenyl]Ethanone Formoterol Intermediate 1-(4-BENZYLOXY-3-NITRO-PHENYL)-2-BROMO-ETHANONE 2-BROMO-4''-BENZYLLOXY-3''-NITROACETOPHENONE 2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanone Formoterol Impurity 23 1-(4-(BenzyL oxy)-3-nitrophenyL Formoterol Impurity 31 Ethanone, 2-bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]- )-2-bromoethanone N-(5-((RS)-2-(benzyl((SR)-1-(4-methoxyphenyl)propan-2-yl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide half-fumarate 2-BROMO-3'-NITRO-4'-BENZYLOXY-ACETOPHENONE 4'-Benzyloxy-2-bromo-3'-nitroacetophenone (phenylmethoxy)phenyl]-ethanone 4-Benzyloxy-3-nitro-alpha-bromoacetophenone 3-Nitro-4-benzyloxy-2-bromophenone 2-bromo-4'-benzyloxy-3'-nitroacetophenone 3'-Nitro-4'-benzyloxy-2-bromobenzophenone 3-Nitro-4-benzyloxy-2-bromoacetophenone 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 43229-01-2 C15H12BrNO4 Intermediate