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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Structure
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone structure
CAS No.
43229-01-2
Chemical Name:
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Synonyms
1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one;3-Nitro-4-benzyloxy-2-bromophenone;4-Benzyloxy-3-nitro-alpha-bromoacetophenone;1-(4-(BenzyL;)-2-bromoethanone;Formoterol Bromide;oxy)-3-nitrophenyL;Formoterol Impurity 23;Formoterol Impurity 31;Formoterol Intermediate
CBNumber:
CB3396148
Molecular Formula:
C15H12BrNO4
Molecular Weight:
350.16
MDL Number:
MFCD06797599
MOL File:
43229-01-2.mol
MSDS File:
SDS
Last updated:2026-05-28 06:24:33
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2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Properties

Melting point 135-137 °C(Solv: ethanol (64-17-5))
Boiling point 465.2±35.0 °C(Predicted)
Density 1.517±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in Methylene chloride, sparingly soluble in ethyl acetate, insoluble in water
form Solid
color Pale yellow to cream coloured crystalline powder
InChI InChI=1S/C15H12BrNO4/c16-9-14(18)12-6-7-15(13(8-12)17(19)20)21-10-11-4-2-1-3-5-11/h1-8H,9-10H2
InChIKey PBAAKBQGBSUCTG-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=C(OCC2=CC=CC=C2)C([N+]([O-])=O)=C1)CBr
CAS DataBase Reference 43229-01-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302 - H315 - H319 - H335
Precautionary statements  P261 - P305+P351+P338
REACH Registrations Active

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-B287165-1G 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 1g $76 2026-06-03 Buy
Matrix Scientific 090612 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 250.00mg $243 2026-05-18 Buy
Matrix Scientific 090612 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 1.00g $538 2026-05-18 Buy
Matrix Scientific 090612 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 43229-01-2 5.00g $1512 2026-05-18 Buy
Synthonix B58160 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone 97% 43229-01-2 250mg $12 2026-05-06 Buy
Product number Packaging Price Buy
TRC-B287165-1G 1g $76 Buy
090612 250.00mg $243 Buy
090612 1.00g $538 Buy
090612 5.00g $1512 Buy
B58160 250mg $12 Buy

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Chemical Properties, Uses, Production

Uses

1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone, can be used as an intermediate in the synthesis of Arformoterol Tartrate (A767505), which is a derivative of Arformoterol, a long acting beta-adrenoceptor agonist drug indicated for the treatment of chronic obstructive pulmonary disease (COPD).

Synthesis

4-Benzyloxy-3-nitroacetophenone

14347-05-8

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

43229-01-2

Step 2: 200 g of 4-benzyloxy-3-nitroacetophenone (Intermediate 1) was dissolved in 1000 mL of dichloromethane and 277 g of trimethylphenylammonium tribromide was added. The reaction mixture was heated to 300 °C and kept for 4 hours. After completion of the reaction, the residual liquid was poured into water, filtered, washed and dried to give 253 g of 3'-nitro-4'-benzyloxy-2-bromoacetophenone in 98% yield.

References

[1] Patent: CN108358791, 2018, A. Location in patent: Paragraph 0016; 0020
[2] Canadian Journal of Chemistry, 2011, vol. 89, # 3, p. 364 - 384
[3] Chirality, 2010, vol. 22, # 2, p. 206 - 211
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 249 - 253
[5] Tetrahedron Asymmetry, 2000, vol. 11, # 13, p. 2705 - 2717

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

4-Benzyloxy-3-nitroacetophenone Dichloromethane Phenyltrimethylammonium bromide

Preparation Products

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Suppliers

Global Suppliers ( 293)
Supplier Tel Email Country ProdList Advantage
SUQIAN DEWEI CHEMICAL CO., LTD. 025-025-58742998 18136843696 sales@deweichem.cn China 171 58
SHENZHEN REISCH BIOTECH CO., LTD 0755-0755-28609002 15112530219 1179151648@qq.com China 236 58
Shaanxi Dideu Medichem Co. Ltd 029-81154043 17391733319 1086@dideu.com China 9970 58
Zhejiang Zetian Fine Chemical Co., Ltd. 0571-87682782 18957127338 sales@zetchem.com China 566 58
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd 18317105404 marketing002@witofly.com China 1600 58
Anhui Goyic Medical Technology Co., Ltd. 0556-5207318 17740878250 sales@goyic.com China 136 58
Jiande Qianhe Welfare Chemical Plant 13968134496 qh@jdqianhe.com China 19 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
SUQIAN DEWEI CHEMICAL CO., LTD. 58
SHENZHEN REISCH BIOTECH CO., LTD 58
Shaanxi Dideu Medichem Co. Ltd 58
Zhejiang Zetian Fine Chemical Co., Ltd. 58
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd 58
Anhui Goyic Medical Technology Co., Ltd. 58
Jiande Qianhe Welfare Chemical Plant 58
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
Energy Chemical 61

View Latest Price from 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone pictures 2026-08-07 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
43229-01-2
 $1.00-4.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone pictures 2026-06-30 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
43229-01-2
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Bromo-4'-Benzyloxy-3'-nitroacetophenone pictures 2026-03-20 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
43229-01-2
 $10.00 100KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Spectrum

2-Bromo-4'-Benzyloxy-3'-nitroacetophenone(43229-01-2)1HNMR

43229-01-2 (2-Bromo-4'-Benzyloxy-3'-nitroacetophenone) Related Search:

Phenyl valerate 3-Nitroacetophenone L-PICEIN 4-Nitroacetophenone 2-Bromoacetophenone
4-Methoxybenzylchloride 4-Nitrobenzyl chloroformate 4-Nitrobenzyl alcohol 4'-Bromoacetophenone Phenyl resin
3-Bromonitrobenzene 4-Nitrobenzyl chloride Phenylacetic acid 3-Nitrophenacylbromide 4-Benzyloxy-3-nitroacetophenone
2'-Bromoacetophenone Nitrogen dioxide 2-Bromo-4'-hydroxy-3'-nitroacetophenone

1of4

ALPHA-BROMO 4-BENZYLOXY-3-NITRO ACETOPHENONE 1-(4-(benzyloxy)-3-nitrophenyl)-2-bromoethan-1-one Formoterol Bromide 2-Bromo-1-[3-Nitro-4-(Phenylmethoxy)Phenyl]Ethanone 2-Bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-ethanone 3-BroMo-1-[3-Nitro-4-(PhenylMethoxy)phenyl]Ethanone Formoterol Intermediate 1-(4-BENZYLOXY-3-NITRO-PHENYL)-2-BROMO-ETHANONE 2-BROMO-4''-BENZYLLOXY-3''-NITROACETOPHENONE 2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanone Formoterol Impurity 23 1-(4-(BenzyL oxy)-3-nitrophenyL Formoterol Impurity 31 Ethanone, 2-bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]- )-2-bromoethanone N-(5-((RS)-2-(benzyl((SR)-1-(4-methoxyphenyl)propan-2-yl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide half-fumarate 2-BROMO-3'-NITRO-4'-BENZYLOXY-ACETOPHENONE 4'-Benzyloxy-2-bromo-3'-nitroacetophenone (phenylmethoxy)phenyl]-ethanone 2-bromo-4'-benzyloxy-3'-nitroacetophenone 3'-Nitro-4'-benzyloxy-2-bromobenzophenone 3-Nitro-4-benzyloxy-2-bromoacetophenone 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone 2-Bromo-1-[3-nitro-4-(benzyloxy)phenyl]-ethanone 3-Nitro-4-benzyloxy-2-bromophenone 4-Benzyloxy-3-nitro-alpha-bromoacetophenone 43229-01-2 C15H12BrNO4 Intermediate