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3-Nitrophenacylbromide

3-Nitrophenacylbromide structure

CAS No.: 2227-64-7

Chemical Name:: 3-Nitrophenacylbromide

Synonyms: 2-BroMo-3&priMe;AKOS BBS-00003963;Alpha-Bromo-3'-nitroacetophenone;3-Nitrophenacylbromid;LABOTEST-BB LT00233190;3-NITROPHENACYL BROMIDE;M-NITROPHENACYL BROMIDE;3'-NITROPHENACYL BROMIDE;a-Bromo-3itroacetophenone

CBNumber:: CB2319971

Molecular Formula:: C8H6BrNO3

Molecular Weight:: 244.04

MDL Number:: MFCD00024512

MOL File:: 2227-64-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-19 07:28:27

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3-Nitrophenacylbromide Properties

Melting point	90-96 °C(lit.)
Boiling point	288.6±15.0 °C(Predicted)
Density	1.8033 (rough estimate)
refractive index	1.6090 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in methanol.
form	Crystalline Powder
color	Beige-orange to yellow-green
BRN	610594
InChI	1S/C8H6BrNO3/c9-5-8(11)6-2-1-3-7(4-6)10(12)13/h1-4H,5H2
InChIKey	GZHPNIQBPGUSSX-UHFFFAOYSA-N
SMILES	[O-][N+](=O)c1cccc(c1)C(=O)CBr
CAS DataBase Reference	2227-64-7(CAS DataBase Reference)
NIST Chemistry Reference	2-Bromo-3'-nitroacetophenone(2227-64-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

Safety Statements

26-27-28-36/37/39-45

RIDADR

UN 3261 8/PG 2

WGK Germany

HazardClass

PackingGroup

III

HS Code

29147000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

NFPA 704

	1
3		0

3-Nitrophenacylbromide price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	344214	2-Bromo-3′-nitroacetophenone 97%	2227-64-7	5g	$64.7	2026-04-30	Buy
Sigma-Aldrich	344214	2-Bromo-3′-nitroacetophenone 97%	2227-64-7	25g	$141	2023-06-20	Buy
TCI Chemical	B2855	2-Bromo-3'-nitroacetophenone	2227-64-7	5G	$20	2026-04-30	Buy
TCI Chemical	B2855	2-Bromo-3'-nitroacetophenone	2227-64-7	25G	$55	2026-04-30	Buy
Usbiological	264234	a-Bromo-3'-nitroacetophenone Asreported	2227-64-7	25g	$420	2026-06-03	Buy

Product number	Packaging	Price	Buy
344214	5g	$64.7	Buy
344214	25g	$141	Buy
B2855	5G	$20	Buy
B2855	25G	$55	Buy
264234	25g	$420	Buy

3-Nitrophenacylbromide Chemical Properties, Uses, Production

Chemical Properties

beige-orange to yellow-green crystalline powder

Uses

2-Bromo-3′-nitroacetophenone may be used in the preparation of 2-bromo-3′-nitroacetophenone. It may be used in the preparation of 2-hydroxy-ethyl-1-[(3-nitro-phenyl)-2-oxoethyl]-piperidinium bromide.

General Description

Debromination of 2-bromo-3′-nitroacetophenone in various solvents has been reported.

Synthesis

121-89-1

2227-64-7

The general procedure for the synthesis of 2-bromo-3'-nitroacetophenone from m-nitroacetophenone is as follows: preparation of 2-bromo-1-(3-nitrophenyl)acetophenone (2a-1). Aluminum chloride (0.16 g, 1.20 mmol) was added to a suspension of commercially available 3-nitroacetophenone (4.82 g, 29.19 mmol) in anhydrous ether (25 mL). The reaction mixture was cooled to 0 °C, followed by the slow dropwise addition of bromine (1.50 mL, 29.19 mmol). The reaction mixture was stirred at room temperature for 1 h until complete conversion of the feedstock (monitored by 1H NMR) and the reaction was quenched quickly to avoid dibromide formation. After addition of water (30 mL), the mixture was extracted with ether (3 x 30 mL) and dried over anhydrous magnesium sulfate to afford compound 2a-1 as a yellow-brown solid (5.73 g, 97% yield).1H NMR (CDCl3, 200 MHz): δ 4.50 (s, 2H, H1), 7.73 (t, J = 8.0 Hz, 1H, H7), 8.31 ( ddd, J = 7.8, 1.7, 1.1 Hz, 1H, H8), 8.43 (ddd, J = 8.2, 2.3, 1.1 Hz, 1H, H6), 8.76 (t, J = 1.9 Hz, 1H, H4).13C NMR (CDCl3, 200 MHz): δ 30.4, 123.9, 128.2, 130.4, 134.6, 135.2, 148.6, 189.5. MS-ESI (m/z): [M + H]+ = 244.9.

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 18, p. 8276 - 8292
[2] Patent: WO2017/17004, 2017, A1. Location in patent: Page/Page column 17
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 10, p. 2192 - 2196
[4] Tetrahedron Letters, 2011, vol. 52, # 31, p. 4026 - 4029
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 10, p. 1424 - 1430

3-Nitrophenacylbromide Preparation Products And Raw materials

Raw materials

Benzene, 1-(2-bromoethynyl)-3-nitro- 3-Nitroacetophenone Aluminum chloride Diethyl ether

Preparation Products

8-Chloro-2-(3-nitrophenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine [4-(3-nitrophenyl)-1,3-thiazol-2-yl]acetonitrile N-(4-(3-nitrophenyl)thiazol-2-yl)acetamide Ethyl 4-(3-aminophenyl)thiazole-2-carboxylate 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine

2-Methyl-4-(3-nitro-phenyl)-thiazole 2-(3-nitrophenyl)H-iMidazo[1,2-a]pyridine

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3-Nitrophenacylbromide Suppliers

Global Suppliers ( 238)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Binchen Chemical Co.，Ltd	13837799094 18351216136	3846935277@qq.com	China	2631	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Shandong Binchen Chemical Co.，Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 3-Nitrophenacylbromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	3-Nitrophenacylbromide 2227-64-7	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	3-Nitrophenacylbromide 2227-64-7		1KG	99%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
2023-10-22	3-Nitrophenacylbromide 2227-64-7		1drums	99%min.	10tons	Shanghai Xinchem Co., Ltd.

3-Nitrophenacylbromide
2227-64-7
$5.00
99%
Henan Fengda Chemical Co., Ltd

3-Nitrophenacylbromide
2227-64-7
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

3-Nitrophenacylbromide
2227-64-7
99%min.
Shanghai Xinchem Co., Ltd.

3-Nitrophenacylbromide Spectrum

3-Nitrophenacylbromide(2227-64-7)MS 3-Nitrophenacylbromide(2227-64-7)¹HNMR 3-Nitrophenacylbromide(2227-64-7)¹³CNMR 3-Nitrophenacylbromide(2227-64-7)IR1 3-Nitrophenacylbromide(2227-64-7)IR2 3-Nitrophenacylbromide(2227-64-7)Raman

2227-64-7 (3-Nitrophenacylbromide) Related Search:

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2-Bromo-3'-nitroacetophenone,97% 2-Bromo-3'-nitroacetophenone, 2-Bromo-1-(3-nitrophenyl)ethan-1-one 2-BroMo-3&priMe 3-Nitro-ɑ-broMoacetophenone 2-Bromo-3'-nitroacetophenone 97% 2-BROMO-1-(3-NITRO-PHENYL)-ETHANONE 2-bromo-1-(3-nitrophenyl)ethan-1-one 3-nitrophenacyl bromide ,2-bromo-1-(3-nitrophenyl)ethanone a-Bromo-3itroacetophenone 3'-Nitro-α-bromoacetophenone A-BROMO-3-NITROACETOPHENONE A-BROMO-M-NITROACETOPHENONE AKOS BBS-00003963 3'-NITRO-2-BROMO ACETOPHENONE 3'-NITROPHENACYL BROMIDE 3-NITROPHENACYL BROMIDE 3-NITRO-ALPHA-BROMOACETOPHENONE LABOTEST-BB LT00233190 M-NITROPHENACYL BROMIDE 3-Nitrophenacylbromide, 97+ alpha-Bromo-3'-nitroacetopheno Acetophenone, 2-bromo-3'-nitro- alpha-Bromo-m-nitroacetophenone -Bromo-3-nltroacetopheone Ethanone, 2-bromo-1-(3-nitrophenyl)- omega-Bromo-m-nitroacetophenone 3-Nitrophenacylbromid 3''-NITROPHENACYL BROMIDE (2-BROMO-3''-NITROACETOPHENONE) -Bromo-3-nitroacetophenone à-bromo-3-nitroacetophenone 2-Bromo-3'-nitroacetophenone > 2-Bromo-3'-nitroacetophenone Alpha-Bromo-3'-nitroacetophenone 2-Bromo-3′-nitroacetophenone, CAS 2227-64-7 Alpha-Bromo-3' -nitroacetophenone 2227-64-7 Organic Building Blocks Ketones KETONE C7 to C8 Carbonyl Compounds Building Blocks Building Blocks C7 to C8 Carbonyl Compounds Chemical Synthesis Ketones Organic Building Blocks Pharmaceutical Intermediates