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5-Methoxy-2-methylaniline

5-Methoxy-2-methylaniline Structure
5-Methoxy-2-methylaniline structure
CAS No.
50868-72-9
Chemical Name:
5-Methoxy-2-methylaniline
Synonyms
NSC 229308;Einecs 256-816-4;6-METHYL-M-ANISIDINE;5-methoxy-o-toluidine;5-Methoxy-2-methylani;LABOTEST-BB LTBB000645;3-Amino-4-methylanisole;5-Methoxy-2-Methylanilin;2-amino-4-methoxytoluene;3-Methoxy-6-methylaniline
CBNumber:
CB3401640
Molecular Formula:
C8H11NO
Molecular Weight:
137.18
MDL Number:
MFCD00075057
MOL File:
50868-72-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:25:54
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5-Methoxy-2-methylaniline Properties

Melting point 43-46 °C (lit.)
Boiling point 253°C(lit.)
Density 1.0630 (rough estimate)
refractive index 1.5647 (estimate)
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
form Powder
pka 4.03±0.10(Predicted)
color Off-white to pale grey to yellow
Water Solubility Slightly soluble in water.
InChI InChI=1S/C8H11NO/c1-6-3-4-7(10-2)5-8(6)9/h3-5H,9H2,1-2H3
InChIKey RPJXLEZOFUNGNZ-UHFFFAOYSA-N
SMILES C1(N)=CC(OC)=CC=C1C
FDA UNII 98CG6GH37M
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS07,GHS06
Signal word  Warning
Hazard statements  H331-H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338-P304+P340-P405-P501a
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39
WGK Germany  3
HazardClass  6.1
HS Code  29222990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

5-Methoxy-2-methylaniline price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 335436 5-Methoxy-2-methylaniline 97% 50868-72-9 1g $44.8 2023-06-20 Buy
Sigma-Aldrich 335436 5-Methoxy-2-methylaniline 97% 50868-72-9 5g $196 2023-06-20 Buy
TCI Chemical M3009 5-Methoxy-2-methylaniline >98.0%(GC)(T) 50868-72-9 1g $47 2024-03-01 Buy
TCI Chemical M3009 5-Methoxy-2-methylaniline >98.0%(GC)(T) 50868-72-9 5g $186 2024-03-01 Buy
TRC TRC-M336795-5G 5-Methoxy-2-methylaniline 50868-72-9 5g $91 2026-06-03 Buy
Product number Packaging Price Buy
335436 1g $44.8 Buy
335436 5g $196 Buy
M3009 1g $47 Buy
M3009 5g $186 Buy
TRC-M336795-5G 5g $91 Buy

5-Methoxy-2-methylaniline Chemical Properties, Uses, Production

Chemical Properties

White to gray to tan crystalline powder

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

Synthesis

4-Methyl-3-nitroanisole

17484-36-5

5-Methoxy-2-methylaniline

50868-72-9

Under nitrogen atmosphere, 4-methoxy-1-methyl-3-nitrobenzene (18.0 g, 108 mmol) was dissolved in 160 mL of 1,2-dimethoxyethane (DME), followed by the addition of 10% Pd/C catalyst (0.9 g). Hydrazine hydrate (16.17 g, 323 mmol) was slowly added dropwise to the above solution. The reaction mixture was heated to reflux and stirred continuously for 4 hours. After that, 3 mL of hydrazine hydrate was added additionally and stirring was continued under reflux conditions for 2 days. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product 5-methoxy-2-methylaniline as a yellow oil. After further vacuum drying, the product solidified to a pale yellow solid in a yield of 14.8 g (100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.94 (d, J = 7.53 Hz, 1H), 6.28 (d, J = 7.53 Hz, 1H), 6.26 (s, 1H), 3.78 (s, 3H), 3.5 (br, 1H), 2.10 (s, 3H), 1.6 (br, 1H).

References

[1] Patent: WO2009/117097, 2009, A1. Location in patent: Page/Page column 70-71
[2] Tetrahedron, 2018, vol. 74, # 12, p. 1294 - 1306
[3] Justus Liebigs Annalen der Chemie, 1882, vol. 215, p. 83
[4] Journal of the Chemical Society, 1929, p. 870
[5] Journal of the Chemical Society, 1925, vol. 127, p. 995

5-Methoxy-2-methylaniline Preparation Products And Raw materials

Raw materials

Acetonitrile Potassium carbonate Glycine Palladium Palladium on activated carbon 5% Pd
4-Methyl-3-nitrophenol Dimethyl sulfate 4-Methyl-3-nitroanisole 1,2-Dimethoxyethane Hydrazine hydrate

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Preparation Products

2-hydroxy-4-Methoxytoluene 3-Fluoro-4-methylanisole 5-Methoxy-8-methyl-quinoline

5-Methoxy-2-methylaniline Suppliers

Global Suppliers ( 156)
Supplier Tel Email Country ProdList Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Supplier Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 64
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Energy Chemical 61
Capot Chemical Co., Ltd 66
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Shanghai Ennopharm Co., Ltd. 65
Sinopharm Chemical Reagent Co,Ltd. 79

View Latest Price from 5-Methoxy-2-methylaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Methoxy-2-methylaniline pictures 2026-03-20 5-Methoxy-2-methylaniline
50868-72-9
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-amino-4-methoxytoluene pictures 2024-04-29 2-amino-4-methoxytoluene
50868-72-9
 $5.00 1kg 99.92% 50000tons Ouhuang Engineering Materials (Hubei) Co., Ltd
5-Methoxy-2-methylaniline pictures 2019-07-12 5-Methoxy-2-methylaniline
50868-72-9
 $1.00 1KG 99% 100kg Career Henan Chemical Co

5-Methoxy-2-methylaniline Spectrum

5-Methoxy-2-methylaniline(50868-72-9)1HNMR5-Methoxy-2-methylaniline(50868-72-9)IR

50868-72-9 (5-Methoxy-2-methylaniline) Related Search:

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3-AMino-4-Methylanisole[5-Methoxy-2-Methylaniline] LABOTEST-BB LTBB000645 5-Methoxy-2-Methylaniline, 97% 1GR 5-Methoxy-2-Methylaniline, 97% 5GR 6-METHYL-M-ANISIDINE 3-Amino-4-methylanisole 3-Methoxy-6-methylaniline Benzenamine, 5-methoxy-2-methyl- NSC 229308 5-Methoxy-2-methylaniline,97% Einecs 256-816-4 5-Methoxy-2-methylaniline,6-Methyl-m-anisidine 5-Methoxy-2-Methylanilin 5-METHOXY-2-METHYLANILINE 5-methoxy-o-toluidine 2-methyl-5-Methoxyaniline 5-Methoxy-2-methylaniline ISO 9001：2015 REACH 5-(Methoxy-d3)-2-methylaniline 2-amino-4-methoxytoluene 5-Methoxy-2-methylani 5-Methoxy-2-methylbenzeneamine 5-Methoxy-2-methylaniline (Standard) 50868-72-9 AMINE Nitrogen Compounds Organic Building Blocks Amines Building Blocks C8 Amines Building Blocks C8 Chemical Synthesis Nitrogen Compounds Organic Building Blocks Anilines, Aromatic Amines and Nitro Compounds