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BAPTA

BAPTA structure

CAS No.: 85233-19-8

Chemical Name:: BAPTA

Synonyms: Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)-;BAPTA;CS-2002;BAPTA,97%;BAPTA, >=98%;BAPTA, Free Acid;BAPTA, 10 mM in DMSO;85233-19-8(free acid);BAPTA, extracellular calcium chelator;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'- TETRAACETI

CBNumber:: CB3406887

Molecular Formula:: C22H24N2O10

Molecular Weight:: 476.43

MDL Number:: MFCD00036255

MOL File:: 85233-19-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:26:42

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BAPTA Properties

Melting point	177-179 °C
Boiling point	575.89°C (rough estimate)
Density	1.4482 (rough estimate)
refractive index	1.6500 (estimate)
RTECS	MC0423000
storage temp.	2-8°C
solubility	Soluble in dimethyl sulfoxide
form	Powder
pka	1.40±0.10(Predicted)
color	White to off-white
Appearance	Solid Powder
Water Solubility	Soluble in water and sodium bicarbonate.
λmax	209 nm, 254 nm, 203 nm, 274 nm
Merck	14,957
BRN	5192406
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Biological Applications	Calcium indicators; zinc indicators; treating acute cell death,cerebral infarction,myocardial infarction,hepatonecrosis,kidney ischemic necrosis,necrotizing pancreatitis,amyloidosis,atherosclerosis,diseases characteriz
InChIKey	FTEDXVNDVHYDQW-UHFFFAOYSA-N
SMILES	OC(=O)CN(CC(O)=O)c1ccccc1OCCOc2ccccc2N(CC(O)=O)CC(O)=O
CAS DataBase Reference	85233-19-8(CAS DataBase Reference)
FDA UNII	K22DDW77C0
UNSPSC Code	12352112
NACRES	NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HS Code

29225090

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

BAPTA price More Price(87)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	1G	$280	2026-04-30	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	50G	$3850	2026-04-30	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	100MG	$62.37	2025-07-31	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	250MG	$105.5	2025-07-31	Buy
TCI Chemical	B3895	1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid >97.0%(HPLC)	85233-19-8	1g	$97	2026-04-30	Buy

Product number	Packaging	Price	Buy
14510	1G	$280	Buy
14510	50G	$3850	Buy
14510	100MG	$62.37	Buy
14510	250MG	$105.5	Buy
B3895	1g	$97	Buy

BAPTA Chemical Properties, Uses, Production

Description

BAPTA free acid (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in cellular signaling.2,3 Non-cell-permeable.

Chemical Properties

White Solid

Uses

Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels.

Uses

BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE.

Uses

As calcium chelator; 19F labelled forms for measurement of intracellular calcium.

Definition

ChEBI: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene.

General Description

In nature 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) is a main metabolic product of BAPTA -AM (BAPTA-tetra(actoxymethyl ester), a neuro protective agent in cerebral ischemia, in rats.BAPTA is an intercellular Ca²⁺ chelator.

Biological Activity

Selective calcium chelator.

storage

Store at +4°C

References

[1] ALBERTO MUÑOZ. Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus.[J]. PLoS ONE, 2015: e0138008. DOI:10.1371/journal.pone.0138008
[2] K. WOZNIAK. Extracellular Ca2+ Is Required for Fertilization in the African Clawed Frog, Xenopus laevis[J]. PLoS ONE, 2017. DOI:10.1371/journal.pone.0170405
[3] MIROSLAVA DIDIASOVA. STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.[J]. The Journal of Biological Chemistry, 2015: 11983-11999. DOI:10.1074/jbc.m114.598425

BAPTA Preparation Products And Raw materials

Raw materials

Sodium dithionite Ammonium hydroxide Hydrazinium hydroxide solution Acetonitrile Ethanol

N,N-Dimethylformamide 2-Nitrophenol N,N-Diisopropylethylamine Palladium Sodium iodide

Ethyl bromoacetate 1,2-Dibromoethane Hydrochloric acid Hydrogen Dichloromethane

Acetic acid Methanol Sodium hydroxide

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Preparation Products

BAPTA Suppliers

Global Suppliers ( 222)

Supplier	Tel	Email	Country	ProdList	Advantage
Hefei NaNo Biological Technology Co., Ltd.	0551-65629887 18010855303	sales@hfnhsw.com	China	268	58
Tianjin Jiayi Biotechnology Co., LTD	13261917876 13261917876	503591062@qq.com	China	493	58
Hefei Qiming Pharmaceutical Technology Co., Ltd	15105695099	123642210@qq.com	China	929	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Hefei NaNo Biological Technology Co., Ltd.	58
Tianjin Jiayi Biotechnology Co., LTD	58
Hefei Qiming Pharmaceutical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shanghai Longsheng chemical Co.,Ltd.	59

View Latest Price from BAPTA manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	BAPTA 85233-19-8	$2.20-8.80	1kg	99%min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-05-11	BAPTA 85233-19-8	$33.00-90.00		97.21%	10g	TargetMol Chemicals Inc.
2021-07-02	1,2-Bis(2-Aminophenoxy)ethane-N,N,N",N"-tetraacetic acid 98% 85233-19-8	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

BAPTA
85233-19-8
$2.20-8.80
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

BAPTA
85233-19-8
$33.00-90.00
97.21%
TargetMol Chemicals Inc.

1,2-Bis(2-Aminophenoxy)ethane-N,N,N",N"-tetraacetic acid 98%
85233-19-8
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BAPTA Spectrum

BAPTA(85233-19-8)¹HNMR

85233-19-8 (BAPTA) Related Search:

Fluo 3-AM RHOD-2, AM BAPTA BAPTA-AM Fura 2-AM

1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrapotassium salt BAPTA, tetrasodium salt Dibromobapta BAPTA tetraethyl ester FURA 2

FLUO 3 NITR 5/AM INDO 1 PENTAPOTASSIUM SALT BAPTA-TMFM FURA 2 PENTAPOTASSIUM SALT

BAPTA-AM 1-[2-(5-Carboxyoxazol-2-yl)-6-aminobenzofuran-5-oxy]-2-(2'-amino-5'-methylphenoxy)-ethane-N,N,N',N'-tetraacetic acid, 5Na Indo 1-am

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BAPTA ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID 1,2-BIS-(O-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid 1,2-BIS(2-AMINOPHENOXY)-ETHANE-N,N,N',N'- TETRAACETIC ACID 97% 2,2',2'',2'''-[Ethylenebisoxybis(2,1-phenylenenitrilo)]tetrakisacetic acid Ethylenebis(oxy-2,1-phenylenenitrilo)tetraacetic acid 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'- TETRAACETI 1,2-Bis-(2-Aminophenoxy) Ethane-N,N,N,-Tetra Acetic Acid BAPTA (1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N'',N'' -TETRAACETIC ACID) CS-2002 N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)glycine 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetic acid >=96.0% (HPLC) BAPTA, >=98% 2,2'-((2-(2-(3-(Bis(carboxymethyl)amino)phenoxy)-ethoxy)phenyl)azanediyl)diacetic acid 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid 1,2-bis(o-aminophenoxy)ethane-n,n, n0,n0-tetraacetic Acid 2,20-(ethylenedioxy)dianiline-n,n,n0, n0-tetraacetic Acid BAPTA, Free Acid 1,2-Bis(2-aminophenoxy)-ethane-N,N,N'N'-tetraacetic acid,97% BAPTA,97% 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid > 1,2-Bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic 2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid 2,2',2'',2'''-(((Ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetic acid Glycine,N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)- BAPTA, extracellular calcium chelator BAPTA, 10 mM in DMSO 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid 85233-19-8(free acid) 2,2',2'',2'''-(((Ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetic acid 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetracetic acid Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)- 85233-19-8 C22H24N2O10 C22H20N2O10 Detection Fluorescent Probes, Labels, Particles and Stains Intracellular Calcium Signaling Cell Signaling and Neuroscience Cell Biology Calcium Chelators Calcium Signaling Research Tools BioChemical Biochemicals and Reagents Aromatic Amines Aromatics Chelating Agents & Ligands Fluorescent Labels & Indicators