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4-Bromobenzonitrile

4-Bromobenzonitrile Structure
4-Bromobenzonitrile structure
CAS No.
623-00-7
Chemical Name:
4-Bromobenzonitrile
Synonyms
P-BROMOBENZONITRILE;4-cyanobromobenzene;1-Bromo-4-cyanobenzene;4-bromobenzoic acid nitrile;PBBN;Of broMoxynil;4-Brombenzonitril;4-bromo-benzonitril;p-Cyanobromobenzene;BROMOBENZONITRILE-4
CBNumber:
CB3423145
Molecular Formula:
C7H4BrN
Molecular Weight:
182.02
MDL Number:
MFCD00001811
MOL File:
623-00-7.mol
MSDS File:
SDS
Last updated:2026-06-04 16:00:12
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4-Bromobenzonitrile Properties

Melting point 110-115 °C(lit.)
Boiling point 235-237 °C(lit.)
Density 1,562 g/cm3
refractive index 1.5999 (estimate)
Flash point 130°C
storage temp. Sealed in dry,Room Temperature
solubility 0.2g/l
form Powder or Flakes
color White to light yellow or flakes
Water Solubility Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether.
BRN 2041518
InChI 1S/C7H4BrN/c8-7-3-1-6(5-9)2-4-7/h1-4H
InChIKey HQSCPPCMBMFJJN-UHFFFAOYSA-N
SMILES Brc1ccc(cc1)C#N
LogP 2.3 at 22.5℃ and pH7
CAS DataBase Reference 623-00-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 32L8XG37J4
NIST Chemistry Reference 4-Bromobenzoic acid nitrile(623-00-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312-H319-H412
Precautionary statements  P264-P273-P280-P301+P312-P302+P352+P312-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,T,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  61-36/37/39-26-24/25
RIDADR  UN 3439 6.1/PG 3
WGK Germany  2
RTECS  DI2460000
Hazard Note  Toxic/Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29269095
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Irrit. 2
REACH Registrations Active
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

4-Bromobenzonitrile price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B58407 4-Bromobenzonitrile 99% 623-00-7 10g $59.1 2026-04-30 Buy
Sigma-Aldrich B58407 4-Bromobenzonitrile 99% 623-00-7 50g $185 2026-04-30 Buy
TCI Chemical B1426 4-Bromobenzonitrile >97.0%(GC) 623-00-7 25g $65 2026-04-30 Buy
TCI Chemical B1426 4-Bromobenzonitrile >97.0%(GC) 623-00-7 250g $394 2026-04-30 Buy
Usbiological 261670 4-Bromobenzonitrile ≥98% 623-00-7 250g $355 2026-06-03 Buy
Product number Packaging Price Buy
B58407 10g $59.1 Buy
B58407 50g $185 Buy
B1426 25g $65 Buy
B1426 250g $394 Buy
261670 250g $355 Buy

4-Bromobenzonitrile Chemical Properties, Uses, Production

Chemical Properties

4-Bromobenzonitrile is white to light yellow powder or flakes

Uses

4- Bromobenzonitrile is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceu ticals and other organic chemicals,

Uses

4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2-bis(di-p-tolylphosphino)- 1,1-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 1925, 1986 DOI: 10.1016/S0040-4039(00)84413-5

Synthesis

To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6 (0.6 mmol,220 mg), K2CO3 (1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMF were added and the mixture was stirred for appropriate reaction time at 120 ℃ under argon atmosphere. The progress of the reaction was monitored by GC analysis. After completion of the reaction, the reaction mixture was washed with 5 mL water, and the crude product was isolated using dichloromethane (5× 1 mL). Organic extracts were combined, evaporated, and purified by flash chromatography using hexane/EtOAc to give 4-Bromobenzonitrile.
4-Bromobenzonitrile

4-Bromobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-Bromobenzamidine hydrochloride 4-Cyanostyrene 1-Boc-4-(4-methoxycarbonylphenyl)piperazine 2-Cyano-5-bromophenylboronic acid pinacol ester 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
4-Cyanophenylboronic acid 4-Bromo-2-chlorobenzonitrile 4-n-Butoxybenzonitrile 4-Guanidinobenzoic acid hydrochloride 4-Cyanobenzophenone
3-(4-Cyano-phenyl)-3-oxo-propionic acid ethyl ester 2,4'-Dibromopropiophenone (4-Cyanobenzyl)phosphonic acid diethyl ester tert-Butyl 4-cyanophenylcarbamate 4-(Pentafluoroethyl)benzonitrile

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4-Bromobenzonitrile Suppliers

Global Suppliers ( 589)
Supplier Tel Email Country ProdList Advantage
wuhankeda 15827391819 283479231@qq.com China 11 58
Qingdao Dexin Chemical Co., Ltd 18353358123 839877395@qq.com China 291 58
Wuhan WinYuanBei Trading Company 86-13349903920 13349903920 869523959@qq.com China 9596 58
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375880 15098789112 3845379039@qq.com China 1457 58
SHANDONG XINGRUNDA CHEMICAL CO.,LTD 0534-18615348689 18615348689 hclt1978@163.com China 35 58
Xintai Huabao Chemical Technology Co., LTD 0538-6378866 13854877258 934928173@qq.com China 9 58
Wuxi Nanfang Chemistry Additives Co.,Ltd. 0510-85580939 18261593783 nanfangchem@126.com China 34 58
Shanghai Binma Technology Co., Ltd. 15262241608 yzxiajie@163.com China 867 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
wuhankeda 58
Qingdao Dexin Chemical Co., Ltd 58
Wuhan WinYuanBei Trading Company 58
Jinan Dexinjia Bio&Tech Co., Ltd 58
SHANDONG XINGRUNDA CHEMICAL CO.,LTD 58
Xintai Huabao Chemical Technology Co., LTD 58
Wuxi Nanfang Chemistry Additives Co.,Ltd. 58
Shanghai Binma Technology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76

View Latest Price from 4-Bromobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
P-BROMOBENZONITRILE pictures 2026-08-25 P-BROMOBENZONITRILE
623-00-7
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
4-Bromobenzonitrile pictures 2026-08-25 4-Bromobenzonitrile
623-00-7
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
4-Bromobenzonitrile pictures 2026-06-30 4-Bromobenzonitrile
623-00-7
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

4-Bromobenzonitrile Spectrum

4-Bromobenzonitrile(623-00-7)MS4-Bromobenzonitrile(623-00-7)1HNMR4-Bromobenzonitrile(623-00-7)13CNMR4-Bromobenzonitrile(623-00-7)IR14-Bromobenzonitrile(623-00-7)IR24-Bromobenzonitrile(623-00-7)Raman

623-00-7 (4-Bromobenzonitrile) Related Search:

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PBBN 4-BROMOBENZONITRILE FOR SYNTHESIS 4-Cyanophenyl bromide p-Cyanobromobenzene p-Cyanophenyl bromide A nitrile of broMobenzene Of broMoxynil 4-BroMobenzonitrile, 98% 10GR 4-bromo-benzonitril Benzonitrile, 4-bromo- Benzonitrile, p-bromo- p-Bromophenyl cyanide BROMOBENZONITRILE-4 1-Bromo-4-cyanobenzene 4-bromobenzoic acid nitrile 4-BROMOBENZONITRILE 4-BROMOCYANOBENZENE 4-BROMO-4'-CYANOBENZENE p-Bromobenzonitrile 4-Bromobenzonitrile 4-BROMBENZONITRILE, 99% 4-Bromobenzonitrile, 98+% 4-cyanobromobenzene 4-Brombenzonitril 4-Bromobenzonitrile 99+% 4-Bromobenzonitrile > Bromfenac Impurity 41 High purity CAS 623-00-7 4-Bromobenzonitrile in stock P-BROMOBENZONITRILE 623-00-7 523-00-7 135459-75-7 C7H4BrN BrC6H4CN Building Blocks for Liquid Crystals Benzonitriles (Building Blocks for Liquid Crystals) ARYL HALIDE Organic Building Blocks Nitrogen Compounds C6 to C7 Building Blocks Cyanides/Nitriles Building Blocks C6 to C7 Chemical Synthesis Nitrogen Compounds Organic Building Blocks Phenyls & Phenyl-Het Nitrile Nitriles Miscellaneous Bromine Compounds Benzonitriles (Building Blocks for Liquid Crystals) Building Blocks for Liquid Crystals Functional Materials Phenyls & Phenyl-Het C6 to C7 Cyanides/Nitriles Nitrogen Compounds