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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid structure

CAS No.: 162046-66-4

Chemical Name:: 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

Synonyms: 4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID;BUTTPARK 98\06-97;Boc-piperazine-benzoic acid;4-[N-Boc-piperazino]benzoic acid;4-(4-Boc-piperazin-1-yl)-benzoic a;4-(4-Boc-1-piperazinyl)benzoic Acid;4-(4-Boc-1-piperazineyl)benzoic acid;1-(4-carboxyphenyl)-4-Boc piperazine;1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID;1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE

CBNumber:: CB6714965

Molecular Formula:: C16H22N2O4

Molecular Weight:: 306.36

MDL Number:: MFCD04115067

MOL File:: 162046-66-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:12:03

Product description	Number	Pack Size	Price
4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester Aldrich	CDS007031	10mg	$77.9
1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	265691	1g	$366
1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	265691	2g	$508
1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	265691	5g	$824
1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	265691	10g	$1155
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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Properties

Melting point	50 °C
Boiling point	476.9±40.0 °C(Predicted)
Density	1.213±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder
pka	5.12±0.10(Predicted)
color	Off-white
InChI	1S/C16H22N2O4/c1-16(2,3)22-15(21)18-10-8-17(9-11-18)13-6-4-12(5-7-13)14(19)20/h4-7H,8-11H2,1-3H3,(H,19,20)
InChIKey	BEDWYXZFIYMEJG-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCN(CC1)c2ccc(cc2)C(O)=O
CAS DataBase Reference	162046-66-4(CAS DataBase Reference)
UNSPSC Code	12352108
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

22-26-36/37/39

Hazard Note

Harmful

HS Code

2933599590

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid price More Price(73)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS007031	4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester Aldrich	162046-66-4	10mg	$77.9	2026-04-30	Buy
Usbiological	265691	1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	162046-66-4	1g	$366	2026-06-03	Buy
Usbiological	265691	1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	162046-66-4	2g	$508	2026-06-03	Buy
Usbiological	265691	1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	162046-66-4	5g	$824	2026-06-03	Buy
Usbiological	265691	1-(4-Boc-piperazin-1-yl)benzoic acid Asreported	162046-66-4	10g	$1155	2026-06-03	Buy

Product number	Packaging	Price	Buy
CDS007031	10mg	$77.9	Buy
265691	1g	$366	Buy
265691	2g	$508	Buy
265691	5g	$824	Buy
265691	10g	$1155	Buy

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Chemical Properties,Uses,Production

Uses

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229)[1].

Synthesis

1-Boc-4-(4-methoxycarbonylphenyl)piperazine

158985-36-5

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

162046-66-4

General procedure for the synthesis of tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate from tert-butyl 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate: 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester (3.2 g, 10 mmol) was reacted with 2M NaOH solution (50 mL) in a mixture of THF (50 mL) and EtOH ( 50 mL) in a mixed solvent and the reaction was stirred at 60 °C for 3 hours. After completion of the reaction, the reaction mixture was concentrated to give a residue. The pH of the residue was adjusted to 7 with 2M HCl solution and filtered to afford tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate as a white solid (3.0 g, 100% yield).

References

[1] Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Preparation Products And Raw materials

Raw materials

Hexane Ethanol 4-Bromobenzonitrile Sodium sulfate Sodium chloride

Potassium carbonate Fumaric acid Piperazine Ethyl acetate Hydrochloric acid

Sodium bicarbonate Dichloromethane Isobutyric anhydride Sodium hydroxide Isopropyl alcohol

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Preparation Products

TERT-BUTYL 4-(4-CARBAMOYLPHENYL)PIPERAZINE-1-CARBOXYLATE 4-PIPERAZIN-1-YL-BENZOIC ACID

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Suppliers

Global( 144)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	+8618062405514	ada@ipurechemical.com	China	10224	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49860	58
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	info@allgreenchem.com	China	5990	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33301	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
Sichuan Yuehe Biopharmaceutical Co., Ltd	+86-838-2806918 +86-18030702676	sales@yuehepharm.com	China	184	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Henan Allgreen Chemical Co.,LTD	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Sichuan Yuehe Biopharmaceutical Co., Ltd	58

View Lastest Price from 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-05	4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 162046-66-4	$5.00	1KG	95%-98%	100kg	Career Henan Chemical Co

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
162046-66-4
$5.00
95%-98%
Career Henan Chemical Co

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Spectrum

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid(162046-66-4)¹HNMR

162046-66-4(4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid)Related Search:

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4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97% 4-(4-Carboxyphenyl)piperazine, N1-BOC protected 4-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]BENZOIC ACID 4-(4-TERT-BUTOXYCARBONYLPIPERAZINE)BENZOIC ACID 4-(4-CARBOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BUTTPARK 98\06-97 4-(4-tert-Butoxycarbonyl)piperazinebenzoic acid 97% 4-Piperazin-1-ylbenzoic acid, N4-BOC protected 97% 4-(4-Carboxy-phenyl)-piperazine-1-carboxylic acid 1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE 1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID 1-(4-CARBOXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID 4-(4-Carboxyphenyl)piperazine-1-carboxylicacidtert-butyleste 4-(4-Boc-1-piperazinyl)benzoic Acid 4-(4-Carboxyphenyl)piperazine, N1-BOC protected, tert-Butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate 4-[N-Boc-piperazino]benzoic acid 4-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic Acid 4-(4-Boc-1-piperazineyl)benzoic acid 1-(4-carboxyphenyl)-4-Boc piperazine (4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid 1-Piperazinecarboxylic acid, 4-(4-carboxyphenyl)-, 1-(1,1-dimethylethyl) ester Boc-piperazine-benzoic acid 4-(4-Boc-piperazin-1-yl)-benzoic a 4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 1-(4-Boc-Piperazin-1-YL)-Benzoic Acid, 4-(4-Carboxy-Phenyl)-Piperazine-1-Carboxylic Acid Tert-Butyl Ester 4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID 162046-66-4 Building Blocks C16 to C29 Chemical Synthesis Heterocyclic Building Blocks New Products for Chemical Synthesis piperazines API intermediates