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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid structure

CAS No.: 162046-66-4

Chemical Name:: 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

Synonyms: 4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID;BUTTPARK 98\06-97;Boc-piperazine-benzoic acid;4-[N-Boc-piperazino]benzoic acid;4-(4-Boc-piperazin-1-yl)-benzoic a;4-(4-Boc-1-piperazinyl)benzoic Acid;4-(4-Boc-1-piperazineyl)benzoic acid;1-(4-carboxyphenyl)-4-Boc piperazine;1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE;1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID

CBNumber:: CB6714965

Molecular Formula:: C16H22N2O4

Molecular Weight:: 306.36

MDL Number:: MFCD04115067

MOL File:: 162046-66-4.mol

Last updated:2026-01-13 11:24:17

Product description	Number	Pack Size	Price
4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester Aldrich	CDS007031	10mg	$73.1
4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoicAcid	B809938	100mg	$75
1-(4-Boc-piperazin-1-yl)benzoic acid	FB50839	1g	$83.6
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97%	4H58-1-W0	1g	$88
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97%	4H58-1-W0	250mg	$24
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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Properties

Melting point	50 °C
Boiling point	476.9±40.0 °C(Predicted)
Density	1.213±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	5.12±0.10(Predicted)
form	powder
color	Off-white
InChI	1S/C16H22N2O4/c1-16(2,3)22-15(21)18-10-8-17(9-11-18)13-6-4-12(5-7-13)14(19)20/h4-7H,8-11H2,1-3H3,(H,19,20)
InChIKey	BEDWYXZFIYMEJG-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCN(CC1)c2ccc(cc2)C(O)=O
CAS DataBase Reference	162046-66-4(CAS DataBase Reference)
UNSPSC Code	12352108
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

22-26-36/37/39

Hazard Note

Harmful

HS Code

2933599590

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS007031	4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester Aldrich	162046-66-4	10mg	$73.1	2025-07-31	Buy
TRC	B809938	4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoicAcid	162046-66-4	100mg	$75	2021-12-16	Buy
Biosynth Carbosynth	FB50839	1-(4-Boc-piperazin-1-yl)benzoic acid	162046-66-4	1g	$83.6	2021-12-16	Buy
SynQuest Laboratories	4H58-1-W0	4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97%	162046-66-4	1g	$88	2021-12-16	Buy
SynQuest Laboratories	4H58-1-W0	4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97%	162046-66-4	250mg	$24	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS007031	10mg	$73.1	Buy
B809938	100mg	$75	Buy
FB50839	1g	$83.6	Buy
4H58-1-W0	1g	$88	Buy
4H58-1-W0	250mg	$24	Buy

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Chemical Properties,Uses,Production

Uses

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229)[1].

Synthesis

1-Boc-4-(4-methoxycarbonylphenyl)piperazine

158985-36-5

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

162046-66-4

General procedure for the synthesis of tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate from tert-butyl 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate: 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester (3.2 g, 10 mmol) was reacted with 2M NaOH solution (50 mL) in a mixture of THF (50 mL) and EtOH ( 50 mL) in a mixed solvent and the reaction was stirred at 60 °C for 3 hours. After completion of the reaction, the reaction mixture was concentrated to give a residue. The pH of the residue was adjusted to 7 with 2M HCl solution and filtered to afford tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate as a white solid (3.0 g, 100% yield).

References

[1] Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Preparation Products And Raw materials

Raw materials

Hexane Ethanol 4-Bromobenzonitrile Sodium sulfate Sodium chloride

Potassium carbonate Fumaric acid Piperazine Ethyl acetate Hydrochloric acid

Sodium bicarbonate Dichloromethane Isobutyric anhydride Sodium hydroxide Isopropyl alcohol

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Preparation Products

TERT-BUTYL 4-(4-CARBAMOYLPHENYL)PIPERAZINE-1-CARBOXYLATE 4-PIPERAZIN-1-YL-BENZOIC ACID

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Suppliers

Global( 142)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hubei Ipure Biology Co., Ltd	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-05	4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 162046-66-4	US $5.00 / KG	1KG	95%-98%	100kg	Career Henan Chemical Co

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
162046-66-4
US $5.00 / KG
95%-98%
Career Henan Chemical Co

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Spectrum

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid(162046-66-4)¹HNMR

162046-66-4(4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid)Related Search:

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4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97% 4-(4-Carboxyphenyl)piperazine, N1-BOC protected 4-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]BENZOIC ACID 4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID 4-(4-TERT-BUTOXYCARBONYLPIPERAZINE)BENZOIC ACID 4-(4-CARBOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BUTTPARK 98\06-97 4-(4-tert-Butoxycarbonyl)piperazinebenzoic acid 97% 4-Piperazin-1-ylbenzoic acid, N4-BOC protected 97% 4-(4-Carboxy-phenyl)-piperazine-1-carboxylic acid 1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE 1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID 1-(4-CARBOXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID 4-(4-Carboxyphenyl)piperazine-1-carboxylicacidtert-butyleste 4-(4-Boc-1-piperazinyl)benzoic Acid 4-(4-Carboxyphenyl)piperazine, N1-BOC protected, tert-Butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate 4-[N-Boc-piperazino]benzoic acid 4-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic Acid 4-(4-Boc-1-piperazineyl)benzoic acid 1-(4-carboxyphenyl)-4-Boc piperazine (4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid 1-Piperazinecarboxylic acid, 4-(4-carboxyphenyl)-, 1-(1,1-dimethylethyl) ester Boc-piperazine-benzoic acid 4-(4-Boc-piperazin-1-yl)-benzoic a 4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 1-(4-Boc-Piperazin-1-YL)-Benzoic Acid, 4-(4-Carboxy-Phenyl)-Piperazine-1-Carboxylic Acid Tert-Butyl Ester 162046-66-4 Building Blocks C16 to C29 Chemical Synthesis Heterocyclic Building Blocks New Products for Chemical Synthesis piperazines API intermediates