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4-Iodo-2-methylphenol

4-Iodo-2-methylphenol Structure
4-Iodo-2-methylphenol structure
CAS No.
60577-30-2
Chemical Name:
4-Iodo-2-methylphenol
Synonyms
NISTC60577302;4-IODO-O-CRESOL;4-iodine-2-cresol;4-Iodo-2-methylphenol;Phenol, 4-iodo-2-Methyl-;4-Iodo-2-Methylphenol 97%
CBNumber:
CB3428160
Molecular Formula:
C7H7IO
Molecular Weight:
234.03
MDL Number:
MFCD00075092
MOL File:
60577-30-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:03
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4-Iodo-2-methylphenol Properties

Melting point 67-68 °C(lit.)
Boiling point 105-110 °C2 mm Hg(lit.)
Density 1.7904 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka 9.70±0.18(Predicted)
Appearance Off-white to light brown Solid
InChI 1S/C7H7IO/c1-5-4-6(8)2-3-7(5)9/h2-4,9H,1H3
InChIKey WSBDSSKIWDFOBQ-UHFFFAOYSA-N
SMILES Cc1cc(I)ccc1O
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

4-Iodo-2-methylphenol price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 337358 4-Iodo-2-methylphenol 97% 60577-30-2 10g $218 2026-04-30 Buy
Activate Scientific AS119408 4-Iodo-2-methylphenol 95% 60577-30-2 1g $29 2026-06-04 Buy
Activate Scientific AS119408 4-Iodo-2-methylphenol 95% 60577-30-2 5g $105 2026-06-04 Buy
Activate Scientific AS119408 4-Iodo-2-methylphenol 95% 60577-30-2 25g $423 2026-06-04 Buy
Matrix Scientific 205309 4-Iodo-2-methylphenol 60577-30-2 5.00g $141 2026-05-18 Buy
Product number Packaging Price Buy
337358 10g $218 Buy
AS119408 1g $29 Buy
AS119408 5g $105 Buy
AS119408 25g $423 Buy
205309 5.00g $141 Buy

4-Iodo-2-methylphenol Chemical Properties, Uses, Production

Uses

4-Iodo-2-methylphenol was used as starting reagent in the synthesis of an agonist for the peroxisome proliferator-activated receptor δ (PPARδ) GW501516, a potential antiobesity drug.

General Description

4-Iodo-2-methylphenol was prepared by direct iodination of 2-methylphenol in aqueous alcohol solvents by the action of a reagent prepared in situ from sodium hypochlorite and sodium iodide.

Synthesis

o-Cresol

95-48-7

4-IODO-2-METHYLPHENOL

60577-30-2

General procedure for the synthesis of 4-iodo-2-cresol from o-cresol: to a stirred solution of o-cresol (1 mmol) in dichloromethane (CH2Cl2) or 1,2-dichloroethane ((CH2Cl)2) (0.1 M) was sequentially added Ph3PAuNTf2 (0.025 mmol, 19 mg; if using a 2:1 Ph3PAuNTf2 with toluene complex with toluene) and N-iodosuccinimide (NIS, 1.1 mmol, 248 mg). The reaction mixture was stirred at room temperature or reacted under reflux conditions until complete conversion of o-cresol was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast column chromatography using different ratios of hexane and ethyl acetate (EtOAc) as eluents, resulting in pure 4-iodo-2-cresol.

References

[1] Synlett, 2014, vol. 25, # 3, p. 399 - 402
[2] Chemistry - A European Journal, 2013, vol. 19, # 7, p. 2442 - 2449
[3] Asian Journal of Chemistry, 2018, vol. 30, # 7, p. 1659 - 1663
[4] Journal of Chemical Research, 2004, # 4, p. 294 - 295
[5] Chinese Chemical Letters, 2012, vol. 23, # 3, p. 261 - 264

4-Iodo-2-methylphenol Preparation Products And Raw materials

Raw materials

o-Cresol Benzene, 1-(2,2-dimethoxyethoxy)-4-iodo-2-methyl- Chloramine-T trihydrate Dichloromethane N-Iodosuccinimide
Triphenylphosphine GOLDI Toluene

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Preparation Products

4-Iodo-2-methylphenol Suppliers

Global Suppliers ( 85)
Supplier Tel Email Country ProdList Advantage
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3828 58
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
Candia Thamtech Company Limited 0371-86615086 18203638366 0371-86159066 13526786601 China 2011 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Xinyanhe Pharmatech Co.,Ltd 0519-85252752 15366845260 taihuaren@vip.163.com China 1032 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Supplier Advantage
Energy Chemical 61
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Wuhan ariel chemical Co., LTD. 58
Hangzhou Sage Chemical Co., Ltd. 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Candia Thamtech Company Limited 60
Bide Pharmatech Ltd. 60
Xinyanhe Pharmatech Co.,Ltd 58
Shanghai HuanChuan Industry Co.,Ltd. 50

View Latest Price from 4-Iodo-2-methylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Iodo-2-methylphenol pictures 2020-01-10 4-Iodo-2-methylphenol
60577-30-2
 $1.00 1g 95-99% 1ton Career Henan Chemical Co

4-Iodo-2-methylphenol Spectrum

4-IODO-2-METHYLPHENOL(60577-30-2)1HNMR4-IODO-2-METHYLPHENOL(60577-30-2)IR4-IODO-2-METHYLPHENOL(60577-30-2)Raman

60577-30-2 (4-Iodo-2-methylphenol) Related Search:

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4-IODO-O-CRESOL NISTC60577302 Phenol, 4-iodo-2-Methyl- 4-Iodo-2-Methylphenol 97% 4-iodine-2-cresol 4-Iodo-2-methylphenol 60577-30-2 60557-30-2 IC6H3CH3OH ALCOHOL Oxygen Compounds Phenols Organic Building Blocks Building Blocks Aromatic Halides (substituted)