7-(Piperidin-1-ylmethyl)quinolin-8-ol
- CAS No.
- 6632-09-3
- Chemical Name:
- 7-(Piperidin-1-ylmethyl)quinolin-8-ol
- Synonyms
- AURORA 23227;AKOS BBS-00001111;OTAVA-BB BB7010150234;NSC57969 >=98% (HPLC);7-(Piperidin-1-ylmethyl)quinolin-8-ol;8-Quinolinol, 7-(1-piperidinylmethyl)-;7-(1-piperidinylmethyl)-8-hydroxyquinoline
- CBNumber:
- CB3434857
- Molecular Formula:
- C15H18N2O
- Molecular Weight:
- 242.32
- MDL Number:
- MFCD00469245
- MOL File:
- Mol file
- TDS File:
- TDS
| Melting point | 194 °C |
|---|---|
| Boiling point | 402.4±30.0 °C(Predicted) |
| Density | 1.202±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 5mg/mL, clear (warmed) |
| pka | 3.81±0.50(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2 |
| InChIKey | WXMFPLZGDXLEMN-UHFFFAOYSA-N |
| SMILES | OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
7-(Piperidin-1-ylmethyl)quinolin-8-ol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1863 | NSC57969 ≥98% (HPLC) | 6632-09-3 | 5MG | $69.54 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML1863 | NSC57969 ≥98% (HPLC) | 6632-09-3 | 25MG | $376 | 2022-05-15 | Buy |
| Biosynth | GAA63209 | NSC-57969 | 6632-09-3 | 25mg | $879.5 | 2026-06-04 | Buy |
| Biosynth | GAA63209 | NSC-57969 | 6632-09-3 | 50mg | $1407 | 2026-06-04 | Buy |
| Biosynth | GAA63209 | NSC-57969 | 6632-09-3 | 100mg | $1959 | 2026-06-04 | Buy |
7-(Piperidin-1-ylmethyl)quinolin-8-ol Chemical Properties, Uses, Production
Uses
NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines[1].
Biological Activity
NSC57969 is a MDR-selective compound th at exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.
References
[1] András Füredi, et al. Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line-Specific Effects from P-Glycoprotein-Induced Toxicity. Mol Cancer Ther. 2017 Jan;16(1):45-56. DOI:10.1158/1535-7163.MCT-16-0333-T
7-(Piperidin-1-ylmethyl)quinolin-8-ol Preparation Products And Raw materials
Raw materials
Preparation Products
7-(Piperidin-1-ylmethyl)quinolin-8-ol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Raise Chemical Technology Co.,Ltd | 55 |
| Energy Chemical | 58 |
| TargetMol Chemicals Inc. | 58 |
