Propargyl benzenesulfonate
- CAS No.
- 6165-75-9
- Chemical Name:
- Propargyl benzenesulfonate
- Synonyms
- Propargyl benzenesulfonate 96%;Acetylene sulfonate;PROPARGYL BENZENESULFOTE;Propynesulfobenzene ester;PRPARGYL BENZENESULFONATE;Propargyl benzenesulfonate;PROPARGYL BENZENESULPHONATE;2-Propynyl Benzenesulfonate;prop-2-ynyl benzenesulfonate;Propargylbenzenesulfonate,95%
- CBNumber:
- CB3453755
- Molecular Formula:
- C9H8O3S
- Molecular Weight:
- 196.22
- MDL Number:
- MFCD00013459
- MOL File:
- 6165-75-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | −30 °C(lit.) |
|---|---|
| Boiling point | 140-142 °C2 mm Hg(lit.) |
| Density | 1.243 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 213 °F |
| storage temp. | 2-8°C |
| form | liquid |
| Appearance | Light brown to brown Liquid |
| BRN | 1107228 |
| InChI | InChI=1S/C9H8O3S/c1-2-8-12-13(10,11)9-6-4-3-5-7-9/h1,3-7H,8H2 |
| InChIKey | RAGBYXLIHQFIPK-UHFFFAOYSA-N |
| SMILES | C(OS(C1=CC=CC=C1)(=O)=O)C#C |
| CAS DataBase Reference | 6165-75-9(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Propyn-1-ol, 1-benzenesulfonate (6165-75-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN 1760 8/PG 2 |
| WGK Germany | 3 |
| F | 10 |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 2905299090 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Propargyl benzenesulfonate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 325341 | Propargyl benzenesulfonate 96% | 6165-75-9 | 100ml | $389 | 2026-04-30 | Buy |
| Usbiological | 287420 | Propargyl benzenesulfonate Asreported | 6165-75-9 | 50g | $333 | 2026-06-03 | Buy |
| Usbiological | 287420 | Propargyl benzenesulfonate Asreported | 6165-75-9 | 100g | $453 | 2026-06-03 | Buy |
| Usbiological | 287420 | Propargyl benzenesulfonate Asreported | 6165-75-9 | 250g | $672 | 2026-06-03 | Buy |
| Usbiological | 287420 | Propargyl benzenesulfonate Asreported | 6165-75-9 | 500g | $991 | 2026-06-03 | Buy |
Propargyl benzenesulfonate Chemical Properties,Uses,Production
Uses
Propargyl Benzenesulfonate is a general chemical reagent used in organic syntheses. Used in the manufacture of Omarigliptin, a DPP-4 inhibitor used in the treatment of type-2 diabetes.
Synthesis
107-19-7
98-09-9
6165-75-9
The general procedure for the synthesis of propargylbenzenesulfonic acid from 2-propyn-1-ol and benzenesulfonyl chloride is as follows: 1.0 mol of 2-propyn-1-ol and 500 mL of methylene chloride were added to a reaction flask, and triethylamine was added as a base under stirring conditions. The reaction mixture was cooled to below 15°C and 2.1 mol of benzenesulfonyl chloride was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was allowed to gradually warm up to room temperature and stirring was continued for 1 hour. Subsequently, the reaction temperature was raised to reflux and the reaction was continued for 2 hours. The progress of the reaction was monitored by gas chromatography and after confirming the completion of the reaction, the reaction mixture was cooled in an ice bath and left to stratify. The organic layer was separated and concentrated to obtain the crude product. The crude product was purified by recrystallization to give 187.77 g of propargyl benzenesulfonic acid in pure form. The yield of the reaction was calculated to be 95.8%, the purity of the product was 99.93%, the moisture content was 28 ppm and the acid value was 36 ppm.
References
[1] Patent: CN107840812, 2018, A. Location in patent: Paragraph 0028; 0029; 0031
[2] Patent: US2340701, 1941,
[3] Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 65
[4] J. Gen. Chem. USSR (Engl. Transl.), 1963, vol. 33, p. 647 - 650
[5] Zhurnal Obshchei Khimii, 1963, vol. 33, # 2, p. 653 - 657
Propargyl benzenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Chemscaler Pharmtech Co., Ltd. | 0519-81096292 15312577869 | chemscaler@yahoo.com.cn | China | 300 | 60 |
| Shanghai RC Chemicals Co., Ltd. | 21-58661250 18217085189; | 3059772675@qq.com | China | 131 | 64 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6744 | 52 |
| Nanjing Chemipioneer Pharma& Tech Co., LTD | 025-52643182 13914798241; | zhoulq@chemipioneer.com.cn | China | 92 | 62 |
| Aemon Chemical | 0086-755-86198205 | acinfo@aemonchem.com | China | 1928 | 57 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
View Lastest Price from Propargyl benzenesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Propargyl benzenesulfonate
6165-75-9
|
$10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | Propargyl benzenesulfonate
6165-75-9
|
$99.60 | 1KG | 98% | 5000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-08-22 | Propargyl Benzenesulfonate
6165-75-9
|
1kg | 99%min | 1 tons | Hangzhou Verychem Science And Technology Co.Ltd |
-
- Propargyl benzenesulfonate
6165-75-9
- $10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Propargyl benzenesulfonate
6165-75-9
- $99.60
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Propargyl Benzenesulfonate
6165-75-9
- $0.00
- 99%min
- Hangzhou Verychem Science And Technology Co.Ltd
