4-Chloro-2-(trifluoromethyl)benzonitrile
- CAS No.
- 320-41-2
- Chemical Name:
- 4-Chloro-2-(trifluoromethyl)benzonitrile
- Synonyms
- oro-2-(trifL;3-Chloro-6-cyanobenzotrifluoride;5-CHLORO-2-CYANOBENZOTRIFLUORIDE;5-Chloro-2-cyanobenzotrifluoride98%;5-Chloro-2-cyanobenzotrifluoride 98%;2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE;4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE;4-chloro-2-(trifluoronethyl)benzonitrile;Benzonitrile, 4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)benzonitrile 98%
- CBNumber:
- CB3454545
- Molecular Formula:
- C8H3ClF3N
- Molecular Weight:
- 205.56
- MDL Number:
- MFCD00060671
- MOL File:
- 320-41-2.mol
- MSDS File:
- SDS
| Boiling point | 109/10mm |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| refractive index | 1.4950 |
| storage temp. | 2-8°C |
| CAS DataBase Reference | 320-41-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332 | |||||||||
| Precautionary statements | P280h-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | T | |||||||||
| RIDADR | UN3276 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
4-Chloro-2-(trifluoromethyl)benzonitrile price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC2708 | 4-Chloro-2-(trifluoromethyl)benzonitrile 98% | 320-41-2 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC2708 | 4-Chloro-2-(trifluoromethyl)benzonitrile 98% | 320-41-2 | 5g | $28 | 2026-06-04 | Buy |
| Apolloscientific | PC2708 | 4-Chloro-2-(trifluoromethyl)benzonitrile 98% | 320-41-2 | 25g | $115 | 2026-06-04 | Buy |
| Activate Scientific | AS26633 | 4-Chloro-2-(trifluoromethyl)benzonitrile 97% | 320-41-2 | 5g | $29 | 2026-06-04 | Buy |
| Activate Scientific | AS26633 | 4-Chloro-2-(trifluoromethyl)benzonitrile 97% | 320-41-2 | 25g | $106 | 2026-06-04 | Buy |
4-Chloro-2-(trifluoromethyl)benzonitrile Chemical Properties,Uses,Production
Application
4-Chloro-2-trifluoromethylbenzonitrile (1) is an important intermediate in the synthesis of bicalutamide. In addition, due to its multiple reaction sites, it is widely used in the preparation of pharmaceutical and chemical intermediates.
Chemical Properties
Yellow liquid
Synthesis
23399-77-1
557-21-1
320-41-2
General procedure for the synthesis of 2-trifluoromethyl-4-chlorobenzonitrile from 2-iodo-5-chlorobenzotrifluoride and zinc cyanide: 4-chloro-1-iodo-2-trifluoromethylbenzene (1500 mg, 4.89 mmol), zinc cyanide (345 mg, 2.94 mmol) and tetrakis(triphenylphosphine)palladium(0) (564 mg, 0.488 mmol), then N,N-dimethylformamide (40 mL) was added. The reaction mixture was heated at 80 °C for overnight reaction. After the reaction was completed, it was cooled to room temperature, the reaction solution was diluted with toluene, washed sequentially with 2N ammonium hydroxide solution (3 times) and saturated aqueous sodium chloride solution, and the organic phase was filtered after drying and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/dichloromethane as eluent to give 4-chloro-2-trifluoromethylbenzonitrile (630 mg, 63% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.81-7.78 (m, 2H), 7.67 (dd, 1H, J = 8.4, 2.4 Hz).
References
[1] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 63
4-Chloro-2-(trifluoromethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Lastest Price from 4-Chloro-2-(trifluoromethyl)benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2024-05-21 | 4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
|
$1.00 | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-09 | 4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
- $3.00
- 98%
- Career Henan Chemical Co
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