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4-Chloro-2-(trifluoromethyl)benzonitrile

4-Chloro-2-(trifluoromethyl)benzonitrile structure

CAS No.: 320-41-2

Chemical Name:: 4-Chloro-2-(trifluoromethyl)benzonitrile

Synonyms: oro-2-(trifL;3-Chloro-6-cyanobenzotrifluoride;5-CHLORO-2-CYANOBENZOTRIFLUORIDE;5-Chloro-2-cyanobenzotrifluoride98%;5-Chloro-2-cyanobenzotrifluoride 98%;2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE;4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE;4-chloro-2-(trifluoronethyl)benzonitrile;Benzonitrile, 4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)benzonitrile 98%

CBNumber:: CB3454545

Molecular Formula:: C8H3ClF3N

Molecular Weight:: 205.56

MDL Number:: MFCD00060671

MOL File:: 320-41-2.mol

MSDS File:: SDS

Last updated:2025-09-09 13:52:16

Product description	Number	Pack Size	Price
4-Chloro-2-(trifluoromethyl)benzonitrile	C598240	500mg	$60
5-Chloro-2-cyanobenzotrifluoride 97%	3837-7-42	1g	$45
5-Chloro-2-cyanobenzotrifluoride 97%	3837-7-42	5G	$95
4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE 95.00%	HCH0023305	1G	$629.48
4-Chloro-2-(trifluoromethyl)benzonitrile	116561	5g	$203
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4-Chloro-2-(trifluoromethyl)benzonitrile Properties

Boiling point	109/10mm
Density	1.43±0.1 g/cm3(Predicted)
refractive index	1.4950
storage temp.	2-8°C
CAS DataBase Reference	320-41-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332

Precautionary statements

P280h-P305+P351+P338-P309-P310

Hazard Codes

RIDADR

UN3276

Hazard Note

Toxic

HazardClass

6.1

PackingGroup

III

HS Code

2926907090

NFPA 704

	1
2		0

4-Chloro-2-(trifluoromethyl)benzonitrile price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C598240	4-Chloro-2-(trifluoromethyl)benzonitrile	320-41-2	500mg	$60	2021-12-16	Buy
SynQuest Laboratories	3837-7-42	5-Chloro-2-cyanobenzotrifluoride 97%	320-41-2	1g	$45	2021-12-16	Buy
SynQuest Laboratories	3837-7-42	5-Chloro-2-cyanobenzotrifluoride 97%	320-41-2	5G	$95	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0023305	4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE 95.00%	320-41-2	1G	$629.48	2021-12-16	Buy
Matrix Scientific	116561	4-Chloro-2-(trifluoromethyl)benzonitrile	320-41-2	5g	$203	2021-12-16	Buy

Product number	Packaging	Price	Buy
C598240	500mg	$60	Buy
3837-7-42	1g	$45	Buy
3837-7-42	5G	$95	Buy
HCH0023305	1G	$629.48	Buy
116561	5g	$203	Buy

4-Chloro-2-(trifluoromethyl)benzonitrile Chemical Properties,Uses,Production

Application

4-Chloro-2-trifluoromethylbenzonitrile (1) is an important intermediate in the synthesis of bicalutamide. In addition, due to its multiple reaction sites, it is widely used in the preparation of pharmaceutical and chemical intermediates.

Chemical Properties

Yellow liquid

Synthesis

23399-77-1

557-21-1

4-Chloro-2-(trifluoromethyl)benzonitrile

320-41-2

General procedure for the synthesis of 2-trifluoromethyl-4-chlorobenzonitrile from 2-iodo-5-chlorobenzotrifluoride and zinc cyanide: 4-chloro-1-iodo-2-trifluoromethylbenzene (1500 mg, 4.89 mmol), zinc cyanide (345 mg, 2.94 mmol) and tetrakis(triphenylphosphine)palladium(0) (564 mg, 0.488 mmol), then N,N-dimethylformamide (40 mL) was added. The reaction mixture was heated at 80 °C for overnight reaction. After the reaction was completed, it was cooled to room temperature, the reaction solution was diluted with toluene, washed sequentially with 2N ammonium hydroxide solution (3 times) and saturated aqueous sodium chloride solution, and the organic phase was filtered after drying and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/dichloromethane as eluent to give 4-chloro-2-trifluoromethylbenzonitrile (630 mg, 63% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.81-7.78 (m, 2H), 7.67 (dd, 1H, J = 8.4, 2.4 Hz).

References

[1] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 63

4-Chloro-2-(trifluoromethyl)benzonitrile synthesis

Synthesis of 4-Chloro-2-(trifluoromethyl)benzonitrile from 5-CHLORO-2-IODOBENZOTRIFLUORIDE and ZINC CYANIDE

4-Chloro-2-(trifluoromethyl)benzonitrile Preparation Products And Raw materials

Raw materials

5-CHLORO-2-IODOBENZOTRIFLUORIDE ZINC CYANIDE N,N-Dimethylformamide Tetrakis(triphenylphosphine)palladium Diisopropyl ether

Preparation Products

4-CHLORO-3-(TRIFLUOROMETHYL)BENZONITRILE

4-Chloro-2-(trifluoromethyl)benzonitrile Suppliers

Global( 176)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8741	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	4000	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58

View Lastest Price from 4-Chloro-2-(trifluoromethyl)benzonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2024-05-21	4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2	US $1.00 / KG	1KG	99%	20t	Shaanxi Dideu Medichem Co. Ltd
2020-01-09	4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2	US $3.00 / KG	1KG	98%	200KG	Career Henan Chemical Co

4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-Chloro-2-(trifluoromethyl)benzonitrile
320-41-2
US $3.00 / KG
98%
Career Henan Chemical Co

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4-CHLORO-2-METHYLBENZONITRILE

1of4

4-chloro-2-(trifluoronethyl)benzonitrile 2-trifluoromethyl-4-chlorophenyl-carbonitrile 2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE 5-CHLORO-2-CYANOBENZOTRIFLUORIDE 4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE 3-Chloro-6-cyanobenzotrifluoride 5-Chloro-2-cyanobenzotrifluoride 98% 5-Chloro-2-cyanobenzotrifluoride98% 4-Chloro-2-(trifluoromethyl)benzonitrile 98% 5-Chloro-2-cyanobenzotrifluoride, 4-Chloro-alpha,alpha,alpha-trifluoro-o-tolunitrile oro-2-(trifL Benzonitrile, 4-chloro-2-(trifluoromethyl)- 320-41-2 320-41-4 Fluorine series Fluorobenzene