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4-Chlorobenzonitrile

4-Chlorobenzonitrile Structure
4-Chlorobenzonitrile structure
CAS No.
623-03-0
Chemical Name:
4-Chlorobenzonitrile
Synonyms
PCBN;Chlorobenzonitrile;P-CHLOROBENZONITRILE;1-CHLORO-4-CYANOBENZENE;AKOS B004081;p-Chlorbenzonitril;P-CHLORBENZONITRILE;p-Chlorotolunitrile;4-Chlorocyanobenzene;4-chloro-benzonitril
CBNumber:
CB4130147
Molecular Formula:
C7H4ClN
Molecular Weight:
137.57
MDL Number:
MFCD00001813
MOL File:
623-03-0.mol
MSDS File:
SDS
Last updated:2026-05-28 02:12:07
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4-Chlorobenzonitrile Properties

Melting point 90-93 °C(lit.)
Boiling point 223 °C(lit.)
Density 1,2 g/cm3
vapor pressure 6.67hPa at 80.4℃
refractive index 1.4530 (estimate)
Flash point 108 °C
storage temp. Sealed in dry,Room Temperature
solubility 0.245g/l practically insoluble
form Flakes or Chunks
color White to yellow
Water Solubility insoluble
BRN 1072122
Henry's Law Constant 2.5×10-1 mol/(m3Pa) at 25℃, Zhang et al. (2010)
InChIKey GJNGXPDXRVXSEH-UHFFFAOYSA-N
LogP 2.47 at 20℃
CAS DataBase Reference 623-03-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 4Z0HGP3A8A
NIST Chemistry Reference 4-Chlorobenzoic acid nitrile(623-03-0)
EPA Substance Registry System 4-Chlorobenzonitrile (623-03-0)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H332-H315-H319-H335
Precautionary statements  P261-P264-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/22-36/37/38
Safety Statements  23-26-36
RIDADR  3439
WGK Germany  2
RTECS  DI2800000
Hazard Note  Harmful
TSCA  TSCA listed
HazardClass  6.1(b)
PackingGroup  III
HS Code  29269095
REACH Registrations Active
NFPA 704
1
2 0

4-Chlorobenzonitrile price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 115622 4-Chlorobenzonitrile 99% 623-03-0 25g $96 2026-04-30 Buy
Sigma-Aldrich 115622 4-Chlorobenzonitrile 99% 623-03-0 100g $335 2026-04-30 Buy
TCI Chemical C0135 4-Chlorobenzonitrile >98.0%(GC) 623-03-0 25g $25 2026-04-30 Buy
TCI Chemical C0135 4-Chlorobenzonitrile >98.0%(GC) 623-03-0 500g $154 2026-04-30 Buy
Usbiological 269371 4-Chlorobenzonitrile Asreported 623-03-0 50g $398 2026-06-03 Buy
Product number Packaging Price Buy
115622 25g $96 Buy
115622 100g $335 Buy
C0135 25g $25 Buy
C0135 500g $154 Buy
269371 50g $398 Buy

4-Chlorobenzonitrile Chemical Properties, Uses, Production

Chemical Properties

4-Chlorobenzonitrile [623-03-0], 4- chloro-1-cyanobenzene, Cl – C6H4 – CN, Mr 137.6, mp 97℃, forms colorless crystals that can be sublimed. The compound is steam volatile, readily soluble in organic solvents, and only sparingly soluble in water. 4-Chlorobenzonitrile is produced industrially by the ammoxidation of 4-chlorotoluene. It is used in the synthesis of a red pigment for plastics.

Uses

4-Chlorobenzonitrile is used to prepare a red pigment for plastics. It is also used in the preparation of amides in organic synthesis. Further, it is used as an intermediate of dye and active pharmaceutical ingredients.

Definition

ChEBI: 4-Chlorobenzonitrile is a member of benzenes and a nitrile.

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1350, 1958 DOI: 10.1021/jo01103a031
Synthetic Communications, 19, p. 1431, 1989 DOI: 10.1080/00397918908054553
Tetrahedron Letters, 31, p. 1063, 1990 DOI: 10.1016/S0040-4039(00)94431-9

Flammability and Explosibility

Non flammable

Synthesis

224 grams of V2O5 was added to a solution consisting of 490 ml of water 468 grams of oxalic acid at a temperature of 80 to 90C, stirred thoroughly, and reacted to obtain a vanadium oxalate solution.

1250 g of SiO2 silica sol at a weight percent concentration of 40% SiO2 was slowly added to the above solution under stirring, and then a solution comprising 864 g of Cr(NO3)3-9H2O, 12.4 g of KNO3 and 500 ml of water, 76.4 g of H3BO3, 85.1 g of 85% phosphoric acid and 500 ml of water and 43.5 g of (NH4)6Mo7O24-4H2O and 100 ml of water were composed of a solution, stirred, heated and evaporated to a solid content of 40% by weight to obtain a viscous slurry.

After the above slurry was formed by spray drying, the catalyst precursor was pre-roasted at 300C for 2 hrs, and then roasted at 650C for 5 hrs to obtain a catalyst composed of atomic ratio: V1.00Cr0.9B0.50P0.30Mo0.10K0.05/SiO2, and the catalyst main loading weight ratio was 50/50.

Property Evaluation of Catalyst Processes Conditions: p-chlorotoluene: ammonia: air = 1:4:25 (molar), catalyst weight loading (WWH) 0.05 h-1, reaction temperature 420 , reaction pressure 0.01 MPa.

Results: p-chlorotoluene conversion    99.6% p-chlorobenzonitrile selectivity  91.5 %, p-chlorobenzonitrile conversion   99.6% p-chlorobenzonitrile selectivity  91.5% p-chlorobenzonitrile conversion   99.6% p-chlorobenzonitrile conversion. nbsp;91.5% p-chlorobenzonitrile yield    91.1%.

4-Chlorobenzonitrile Preparation Products And Raw materials

Raw materials

4-Chlorobenzoic acid Urea

Preparation Products

2-(4-chlorophenyl)-3-oxovaleronitrile 4-Piperazinobenzonitrile 4-Chlorobenzene-1-carboximidamide hydrochloride 4-Chlorobenzamidine hydroiodide 4,4'-Dicarboxydiphenyl Ether
4-Chloro-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile Pigment Red 254 4-n-Butoxybenzonitrile 3-(4-Cyano-phenyl)-3-oxo-propionic acid ethyl ester tert-Butyl 4-cyanophenylcarbamate
4-Cyanothiophenol 4-Ethoxybenzonitrile 4,4'-Biphenyldicarbonitrile 4-Chloro-3-(trifluoromethyl)benzonitrile 3-Bromo-4-chlorobenzonitrile
4'-Hydroxy-4-biphenylcarbonitrile 4-Cyanobenzenesulfonyl chloride 97

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4-Chlorobenzonitrile Suppliers

Global Suppliers ( 604)
Supplier Tel Email Country ProdList Advantage
Weifang QianJin Fine Chemical Co., Ltd. 18753684562 1577399715@qq.COM China 1788 55
Ningtai Chemical (Shandong) Co., Ltd 15314216173 2045904044@qq.com China 205 58
Shandong Junfeng New Materials Co., Ltd. 17663721258 17663721258 17663721258@163.com China 365 58
Tenghong (Shandong) New Material Co., Ltd 1555-2555846 18265060865 1277177917@qq.com China 2938 58
Xintai Huabao Chemical Technology Co., LTD 13854877258 934928173@qq.com China 9 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Supplier Advantage
Weifang QianJin Fine Chemical Co., Ltd. 55
Ningtai Chemical (Shandong) Co., Ltd 58
Shandong Junfeng New Materials Co., Ltd. 58
Tenghong (Shandong) New Material Co., Ltd 58
Xintai Huabao Chemical Technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57

View Latest Price from 4-Chlorobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chlorobenzonitrile pictures 2026-11-04 4-Chlorobenzonitrile
623-03-0
 1kg 99%min 20tons HANGZHOU HAILAN CHEMICAL CO.,LTD.
4-Chlorobenzonitrile pictures 2026-05-28 4-Chlorobenzonitrile
623-03-0
 $9.10 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
4-Chlorobenzonitrile pictures 2026-03-20 4-Chlorobenzonitrile
623-03-0
 $10.00 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd

4-Chlorobenzonitrile Spectrum

4-Chlorobenzonitrile(623-03-0)MS4-Chlorobenzonitrile(623-03-0)1HNMR4-Chlorobenzonitrile(623-03-0)13CNMR4-Chlorobenzonitrile(623-03-0)IR14-Chlorobenzonitrile(623-03-0)IR24-Chlorobenzonitrile(623-03-0)Raman

623-03-0 (4-Chlorobenzonitrile ) Related Search:

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4-CYANOCHLOROBENZENE 4-CHLOROBENZONITRILE AKOS B004081 LABOTEST-BB LT01147713 P-CHLORBENZONITRILE 4-chloro-benzonitril 1-Cyano-4-chlorobenzene 4-Chlorocyanobenzene 4-Cyanophenyl chloride 4-Chlorobenzenecarbonitrile Of dichlorobenzonitrile 4-Chlorobenzonitrile, 99% 25GR 4-CHLOROBENZONITRILE FOR SYNTHESIS Chlorobenzenecarbonitrile Chlorobenzene nitrile high purity 4-Chlorobenzonitrile with good price kf-wang(at)kf-chem.com 4-Chlorobenzonitrile 623-03-0 PCBN p-Chlorobenzonitrile 623-03-0 PCBN 4-Chlorobenzonitrile kf-yuwen(at)kf-chem.com Benzonitrile, 4-chloro- Benzonitrile, p-chloro- Nitril kyseliny p-chlorbenzoove nitrilkyselinyp-chlorbenzoove p-chloro-benzonitril p-Chlorocyanobenzene p-Cyanochlorobenzene p-Chlorotolunitrile 4-Chlorobenzonitrile,99% PARA-CHLOROBENZONITRILE p-Chlorbenzonitril 4-Chlorobenzonitrile > 4-Chlorobenzonitrile Basic information Crisaborole 4-chlorobenzonitrile 13C6]-4-Chlorobenzonitrile parachlorobenzenitrile P-CHLOROBENZONITRILE 1-CHLORO-4-CYANOBENZENE Chlorobenzonitrile PCBN 623-03-0 623-03-3 623-03-4 135438-99-1 623-02-0 ClC6H4CN C7H4CIN Building Blocks for Liquid Crystals Benzonitriles (Building Blocks for Liquid Crystals) Nitrogen Compounds Organic Building Blocks Cyanides/Nitriles C6 to C7 Building Blocks Pesticides intermediate cyanide| alkyl chloride Cyanides/Nitriles Nitrogen Compounds Benzonitriles (Building Blocks for Liquid Crystals)