PF-6808472
- CAS No.
- 2088112-70-1
- Chemical Name:
- PF-6808472
- Synonyms
- XO44;PF-6808472;4-((4-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-6-(prop-2-yn-1-ylcarbamoyl)pyrimidin-2-yl)piperazin-1-yl)methyl)benzenesulfonyl fluoride;Benzenesulfonyl fluoride, 4-[[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-[(2-propyn-1-ylamino)carbonyl]-2-pyrimidinyl]-1-piperazinyl]methyl]-
- CBNumber:
- CB34668382
- Molecular Formula:
- C25H27FN8O3S
- Molecular Weight:
- 538.6
- MDL Number:
- MOL File:
- 2088112-70-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.452±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: 5mg/mL, clear (warmed) |
| form | powder |
| pka | 11.23±0.46(Predicted) |
| color | white to beige |
| InChIKey | ZBSPMOBILDLOCV-UHFFFAOYSA-N |
| SMILES | F[S](=O)(=O)c1ccc(cc1)CN2CCN(CC2)c3nc(cc(n3)C(=O)NCC#C)Nc4n[nH]c(c4)C5CC5 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| RIDADR | UN 3265 8 / PGII |
| WGK Germany | WGK 3 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
PF-6808472 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0306 | PF-6808472 ≥98% (HPLC) | 2088112-70-1 | 5mg | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | PZ0306 | PF-6808472 ≥98% (HPLC) | 2088112-70-1 | 25mg | $480 | 2026-04-30 | Buy |
| Biosynth | NID11270 | PF-6808472 | 2088112-70-1 | 50mg | $2301 | 2026-06-04 | Buy |
| ChemScene | CS-0087471 | XO44 99.38% | 2088112-70-1 | 5mg | $152 | 2026-06-04 | Buy |
| ChemScene | CS-0087471 | XO44 99.38% | 2088112-70-1 | 10mg | $260 | 2026-06-04 | Buy |
PF-6808472 Chemical Properties, Uses, Production
Uses
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2].
Biochem/physiol Actions
PF-6808472 is a cell permeable covalent probe suitable for click chemistry designated to measure kinase selectivity in intact cells. PF-6808472 contains sulfonyl fluoride group, which react with conserved lysine residue within kinase ATP binding site.
IC 50
CDK4; CDK1; CDK2
References
[1] Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. DOI:10.1021/acs.jmedchem.1c00159
[2] Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366(6471):eaaw2106. DOI:10.1126/science.aaw2106
PF-6808472 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-6808472 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 975 | 58 |
| Hangzhou Taorui Biotechnology Co., Ltd | QQ1259737804 15268198094 | sales@torreybio.com | China | 4130 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from PF-6808472 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | PF-6808472
2088112-70-1
|
$455.00-787.00 | 99.02% | 10g | TargetMol Chemicals Inc. |
-
- PF-6808472
2088112-70-1
- $455.00-787.00
- 99.02%
- TargetMol Chemicals Inc.
