tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate
- CAS No.
- 156185-63-6
- Chemical Name:
- tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate
- Synonyms
- 3-(1-Boc-4-piperidyl)-1-propanol;Boc-4-piperidinepropanol;N-Boc-4-piperidinepropanol;3-(N-Boc-piperidin-4-yl)propanol;N-BOC-4-(3'-propanol)-piperidine;1-N-BOC-4-(3'-PROPANOL)-PIPERIDINE;N-Boc-4-(3-Hydroxypropyl)piperidine;83-(1-Boc-4-piperidinyl)-1-propanol;4-(3-Hydroxypropyl)piperidine, N-BOC protected;4-(3-Hydroxyprop-1-yl)piperidine, N-BOC protected
- CBNumber:
- CB3466926
- Molecular Formula:
- C13H25NO3
- Molecular Weight:
- 243.34
- MDL Number:
- MFCD02677712
- MOL File:
- 156185-63-6.mol
- MSDS File:
- SDS
| Boiling point | 339.8±15.0 °C(Predicted) |
|---|---|
| Density | 1.029 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 15.16±0.10(Predicted) |
| form | Low-Melting Solid |
| color | White to Off-White |
| InChI | InChI=1S/C13H25NO3/c1-13(2,3)17-12(16)14-8-6-11(7-9-14)5-4-10-15/h11,15H,4-10H2,1-3H3 |
| InChIKey | OXPWHPCCUXESFQ-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(CCCO)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| Hazard Note | Irritant |
| HS Code | 2933399990 |
tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B694715-100MG | tert-Butyl 4-(3-Hydroxypropyl)piperidine-1-carboxylate | 156185-63-6 | 100mg | $65 | 2026-06-03 | Buy |
| AstaTech | 54965 | 1-N-BOC-4-(3'-PROPANOL)-PIPERDINE 97% | 156185-63-6 | 5G | $45 | 2026-04-30 | Buy |
| AstaTech | 54965 | 1-N-BOC-4-(3'-PROPANOL)-PIPERDINE 97% | 156185-63-6 | 25G | $185 | 2026-04-30 | Buy |
| AstaTech | 54965 | 1-N-BOC-4-(3'-PROPANOL)-PIPERDINE 97% | 156185-63-6 | 100G | $742 | 2026-04-30 | Buy |
| Biosynth | FT31203 | Tert-butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate | 156185-63-6 | 25g | $625 | 2026-06-04 | Buy |
tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate Chemical Properties, Uses, Production
Uses
tert-Butyl 4-(3-Hydroxypropyl)piperidine-1-carboxylate is a reagent in the preparation of 1-alkyloxy-2-methoxy-4-nitrobenzene fragments: potent human glutaminyl cyclase inhibitors.
Synthesis
7037-49-2
24424-99-5
156185-63-6
The general procedure for the synthesis of N-BOC-4-(3'-hydroxypropyl)-piperidine from 3-(4-piperidinyl)-1-propanol and di-tert-butyl dicarbonate was as follows: 1. Di-tert-butyl dicarbonate (3.66 g, 16.8 mmol) was slowly added to a stirring solution of anhydrous dichloromethane (20 mL) of 3-(4-piperidinyl)-1-propanol (1.60 g, 11.2 mmol) under nitrogen protection and the reaction was carried out at ambient temperature. 2. The resulting reaction mixture was stirred continuously for 2 hours. 3. Upon completion of the reaction, the mixture was purified directly by silica gel column chromatography with the eluent being methanol in dichloromethane (0-3% gradient). 4. The target fraction was collected to afford N-BOC-4-(3'-hydroxypropyl)-piperidine as a clear oil (2.40 g, 88% yield).
References
[1] Organic Letters, 2002, vol. 4, # 4, p. 549 - 552
[2] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 5-6
[3] Patent: US6235731, 2001, B1
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 5, p. 783 - 794
[5] Tetrahedron, 1999, vol. 55, # 39, p. 11619 - 11639
tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AF Biochem Co., Ltd. | +86-028-60911900 13540204019 | sales@afbiochem.com | China | 479 | 57 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | zwchem@163.com | China | 522 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
156185-63-6
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
156185-63-6
- $1.00
- 99%
- Career Henan Chemical Co
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