N-BOC-4-(3-羟丙基)-哌啶

N-BOC-4-(3-羟丙基)-哌啶性质、用途与生产工艺

生产方法 

7037-49-2

24424-99-5

156185-63-6

以3-(4-哌啶基)-1-丙醇和二碳酸二叔丁酯为原料，合成N-BOC-4-(3'-羟丙基)-哌啶的一般步骤如下： 1. 在氮气保护下，将二碳酸二叔丁酯（3.66 g，16.8 mmol）缓慢加入搅拌中的3-(4-哌啶基)-1-丙醇（1.60 g，11.2 mmol）的无水二氯甲烷（20 mL）溶液中，反应在环境温度下进行。 2. 将所得反应混合物持续搅拌2小时。 3. 反应完成后，直接将混合物通过硅胶柱色谱进行纯化，洗脱剂为二氯甲烷中的甲醇（0-3%梯度）。 4. 收集目标组分，得到N-BOC-4-(3'-羟丙基)-哌啶，为透明油状物（2.40 g，收率88%）。

参考文献：

[1] Organic Letters, 2002, vol. 4, # 4, p. 549 - 552

[2] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 5-6

[3] Patent: US6235731, 2001, B1

[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 5, p. 783 - 794

[5] Tetrahedron, 1999, vol. 55, # 39, p. 11619 - 11639

N-BOC-4-(3-羟丙基)-哌啶 上下游产品信息

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