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ChemicalBook >> CAS DataBase List >>trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Structure
trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane structure
CAS No.
852948-13-1
Chemical Name:
trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane
Synonyms
VK-2809;MB-07811 ( VK-2809);4-(3-chlorophenyl)-2-((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)-1,3,2-dioxaphosphinane 2-oxide;(2R,4S)-4-(3-chlorophenyl)-2-((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)-1,3,2-dioxaphosphinane 2-oxide;trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane;4-[[4-[[(2R,4S)-4-(3-Chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-(1-methylethyl)phenol;Phenol, 4-[[4-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-(1-methylethyl)-
CBNumber:
CB34694404
Molecular Formula:
C28H32ClO5P
Molecular Weight:
514.98
MDL Number:
MFCD18827432
MOL File:
852948-13-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:33:07
Product description Number Pack Size Price
MB-07811 ≥98% 30670 1mg $39
MB-07811 ≥98% 30670 5mg $154
MB-07811 ≥98% 30670 10mg $270
MB-07811 ≥98% 30670 25mg $578
MB 07811 CJB94813 5mg $285.55
Request For Quotation

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Properties

Melting point 77-82 °C
Boiling point 660.6±55.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
solubility Acetonitrile: Soluble
DMSO: Soluble
pka 10.31±0.30(Predicted)
form Solid
InChIKey LGGPZDRLTDGYSQ-WJVKJDHCSA-N
SMILES O1CC[C@@H](C2=CC=CC(Cl)=C2)O[P@@]1(COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1)=O
FDA UNII 3Z11398FNQ

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30670 MB-07811 ≥98% 852948-13-1 1mg $39 2026-04-30 Buy
Cayman Chemical 30670 MB-07811 ≥98% 852948-13-1 5mg $154 2026-04-30 Buy
Cayman Chemical 30670 MB-07811 ≥98% 852948-13-1 10mg $270 2026-04-30 Buy
Cayman Chemical 30670 MB-07811 ≥98% 852948-13-1 25mg $578 2026-04-30 Buy
Biosynth CJB94813 MB 07811 852948-13-1 5mg $285.55 2026-06-04 Buy
Product number Packaging Price Buy
30670 1mg $39 Buy
30670 5mg $154 Buy
30670 10mg $270 Buy
30670 25mg $578 Buy
CJB94813 5mg $285.55 Buy

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Chemical Properties,Uses,Production

Uses

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].

in vivo

MB-07811 (VK-2809) (0.3-30 mg/kg; orally once daily for 14 days) reduces cholesterol and triglycerides in diet-induced obese mice[2].

Animal Model:4-week-old male C57BL/6 mice (diet-induced obese (DIO) mice)[2]
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Orally once daily; 14 days
Result:Reduced total plasma cholesterol, and reduced plasma triglycerides (40%) at the highest doses.

References

[1] Cable EE, et al. Reduction of hepatic steatosis in rats and mice after treatment with aliver-targeted thyroidhormone receptor agonist. Hepatology. 2009 Feb;49(2):407-17. DOI:10.1002/hep.22572
[2] Erion MD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. DOI:10.1073/pnas.0702759104
[3] SERGE H. BOYER*. Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic Acid Thyroid Hormone Receptor Agonists and Their Prodrugs[J]. Journal of Medicinal Chemistry, 2008, 51 22: 7075-7093. DOI: 10.1021/jm800824d

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Preparation Products And Raw materials

Raw materials

Preparation Products

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Suppliers

Global( 51)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
Nantong HI-FUTURE Biology Co., Ltd. 		+86-18051384581 sales@chemhifuture.com China 3123 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9937 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740 sales@bicbiotech.com China 5990 58
Guangzhou CATO Research Chemicals Inc. 		+86-020-81960175-617 18520203721 Intermediate@cato-chem.com China 3857 58
Chongqing jooe co., ltd 		+86-15223382610 info@jooe.com China 15967 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Nanjing Bicbiotechnology Co., Ltd 		58
Guangzhou CATO Research Chemicals Inc. 		58
Chongqing jooe co., ltd 		58
Chuzhou KeMail Chemical Technology Co., Ltd 55

View Lastest Price from trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MB-07811 pictures 2026-04-22 MB-07811
852948-13-1
 $95.00-371.00 99.94% 10g TargetMol Chemicals Inc.
  • MB-07811 pictures
  • MB-07811
    852948-13-1
  • $95.00-371.00
  • 99.94%
  • TargetMol Chemicals Inc.

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Spectrum

trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane(852948-13-1)1HNMR

852948-13-1(trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane)Related Search:

((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid(WXG00614) trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane Phenol, 4-[[4-[[(2S,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-(1-methylethyl)- MB 07811 Phenol, 4-[(1R)-5-[[(R)-[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-1-yl][(2R,6S)-2-oxido-1,3,2-dioxaphosphorinan-3-yl]phosphinyl]methoxy]-2,3-dihydro-7-methyl-1H-inden-1-yl]-2-(1-methylethyl)-
QRX 431

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(2R,4S)-4-(3-chlorophenyl)-2-((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)-1,3,2-dioxaphosphinane 2-oxide MB-07811 ( VK-2809) 4-(3-chlorophenyl)-2-((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)-1,3,2-dioxaphosphinane 2-oxide 4-[[4-[[(2R,4S)-4-(3-Chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-(1-methylethyl)phenol Phenol, 4-[[4-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-(1-methylethyl)- trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane VK-2809 852948-13-1 C28H32ClO5P API VK2809