AG-10 1446711-81-4
- CAS No.
- 1446711-81-4
- Chemical Name:
- AG-10 1446711-81-4
- Synonyms
- Acoramidis;3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid;AG10,AG 10;Acoramidis (AG-10);AG-10 1446711-81-4;AG-10, 10 mM in DMSO;Benzoic acid, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluoro-;3-[3-(3,5-Dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid (ACI)
- CBNumber:
- CB34694530
- Molecular Formula:
- C15H17FN2O3
- Molecular Weight:
- 292.31
- MDL Number:
- MOL File:
- 1446711-81-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 542.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.282±0.06 g/cm3(Predicted) |
| solubility |
DMSO: Soluble: =10 mg/ml Ethanol: Slightly soluble: 0.1-1 mg/ml |
| pka | 3.98±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20) |
| InChIKey | WBFUHHBPNXWNCC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(F)C(OCCCC2=C(C)NN=C2C)=C1 |
| FDA UNII | T12B44A1OE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
AG-10 1446711-81-4 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41522 | Acoramidis ≥98% | 1446711-81-4 | 5mg | $248 | 2026-04-30 | Buy |
| Cayman Chemical | 41522 | Acoramidis ≥98% | 1446711-81-4 | 10mg | $446 | 2026-04-30 | Buy |
| Cayman Chemical | 41522 | Acoramidis ≥98% | 1446711-81-4 | 25mg | $990 | 2026-04-30 | Buy |
| Cayman Chemical | 41522 | Acoramidis ≥98% | 1446711-81-4 | 50mg | $1362 | 2026-04-30 | Buy |
| ChemScene | CS-0116350 | Acoramidis 98.47% | 1446711-81-4 | 1mg | $65 | 2026-06-04 | Buy |
AG-10 1446711-81-4 Chemical Properties,Uses,Production
Uses
Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis[1][2].
in vivo
| Animal Model: | Wistar rats[1]. |
| Dosage: | 50 mg/kg/d (Toxicity Analysis). |
| Administration: | Oral gavage, daily for 28 d. |
| Result: | Showed the plasma Cmax of ～40 μM and histopathological evaluation of liver, kidney, heart, spleen, thymus, and lung showed no signs of pathologic processes in the AG10-treated animals |
References
[1] Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. DOI:10.1073/pnas.1300761110
[2] Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. DOI:10.1002/cpdd.700
[3] Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. DOI:10.1074/jbc.M305396200
AG-10 1446711-81-4 Preparation Products And Raw materials
Raw materials
Preparation Products
AG-10 1446711-81-4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Zhongzhi Biotechnology Co., Ltd | zhongzhipharma@126.c 15066129350 | zhongzhipharma@126.com | China | 9963 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Famo Bio-chemical Technology Company Ltd. | 021-36680027 15821745250 | fengqiang@famobiotech.com | China | 494 | 56 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2283 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7580 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Wuhan Sun-shine Bio-technology Corporation Limited | +86-027-6552-2453 | sales@sun-shinechem.com | China | 725 | 58 |
