3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
- CAS No.
- 2242751-53-5
- Chemical Name:
- 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
- Synonyms
- Acoramidis hydrochloride;AG10 hydrochloride;Acoramidis hydrochloride, 10 mM in DMSO;Acoramidis?hydrochloride?(AG10 hydrochloride);Acoramidis Hydrochloride,2242751-53-5,Pharmaceutical Chemicals;3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL;3-(3-(3,5-Dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid hydrochloride;Benzoic acid, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluoro-, hydrochloride (1:1) (ACI)
- CBNumber:
- CB94800979
- Molecular Formula:
- C15H18ClFN2O3
- Molecular Weight:
- 328.77
- MDL Number:
- MFCD33023202
- MOL File:
- 2242751-53-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| solubility | DMSO: Sparingly soluble: 1-10 mg/ml |
|---|---|
| form | Solid |
| color | White to light yellow |
| InChI | InChI=1S/C15H17FN2O3.ClH/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16;/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20);1H |
| InChIKey | MGFZEARHINUOMX-UHFFFAOYSA-N |
| SMILES | O(C1C(=CC=C(C(=O)O)C=1)F)CCCC1=C(NN=C1C)C.Cl |
| FDA UNII | VY9C88C2NV |
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41536 | Acoramidis (hydrochloride) ≥98% | 2242751-53-5 | 5mg | $138 | 2026-04-30 | Buy |
| Cayman Chemical | 41536 | Acoramidis (hydrochloride) ≥98% | 2242751-53-5 | 10mg | $248 | 2026-04-30 | Buy |
| Cayman Chemical | 41536 | Acoramidis (hydrochloride) ≥98% | 2242751-53-5 | 25mg | $550 | 2026-04-30 | Buy |
| Cayman Chemical | 41536 | Acoramidis (hydrochloride) ≥98% | 2242751-53-5 | 50mg | $963 | 2026-04-30 | Buy |
| ChemScene | CS-0143619 | Acoramidis hydrochloride 98.47% | 2242751-53-5 | 1mg | $65 | 2026-06-04 | Buy |
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Chemical Properties, Uses, Production
Uses
Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis[1][2].
in vivo
| Animal Model: | Wistar rats[1]. |
| Dosage: | 50 mg/kg/d (Toxicity Analysis). |
| Administration: | Oral gavage, daily for 28 d. |
| Result: | Showed the plasma Cmax of ～40 μM and histopathological evaluation of liver, kidney, heart, spleen, thymus, and lung showed no signs of pathologic processes in the AG10-treated animals |
References
[1] Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. DOI:10.1073/pnas.1300761110
[2] Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. DOI:10.1002/cpdd.700
[3] Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. DOI:10.1074/jbc.M305396200
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Preparation Products And Raw materials
Raw materials
Preparation Products
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suli Pharmaceutical Technology Co., Ltd. | 021-58086325-8060 13636568474 | yingjie.zhang@suli.com | China | 97 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Shanghai Famo Bio-chemical Technology Company Ltd. | 021-36680027 15821745250 | fengqiang@famobiotech.com | China | 494 | 56 |
| Shanghai Synteam Biochem CO.,ltd | +86-021-58380978 13482386415 | info@systeambc.com | China | 897 | 50 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9959 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
View Latest Price from 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-26 | Acoramidis Hydrochloride
2242751-53-5
|
100g | ＞98% | 5 KG | Zhejiang Hengkang Pharmaceutical Co.Ltd. | ||
 |
2026-07-15 | Acoramidis hydrochloride
2242751-53-5
|
$48.00-198.00 | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
2242751-53-5
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- Acoramidis Hydrochloride
2242751-53-5
- $0.00
- ＞98%
- Zhejiang Hengkang Pharmaceutical Co.Ltd.
-
- Acoramidis hydrochloride
2242751-53-5
- $48.00-198.00
- 99.57%
- TargetMol Chemicals Inc.
-
- 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
2242751-53-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
