ChemicalBook >> CAS DataBase List >>N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
- CAS No.
- 143655-70-3
- Chemical Name:
- N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
- Synonyms
- Exatecan Impurity 8;Exatecan Intermediate 5;N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide;Acetamide, N,N'-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1,7-naphthalenediyl)bis- (9CI)
- CBNumber:
- CB34804586
- Molecular Formula:
- C15H17FN2O3
- Molecular Weight:
- 292.31
- MDL Number:
- MFCD31657913
- MOL File:
- 143655-70-3.mol
- MSDS File:
- SDS
Last updated:2026-05-28 01:58:07
| Boiling point | 596.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| pka | 13.55±0.40(Predicted) |
| form | Solid |
| color | Off-white to gray |
| InChI | InChI=1S/C15H17FN2O3/c1-7-10-4-5-12(17-8(2)19)15(21)14(10)13(6-11(7)16)18-9(3)20/h6,12H,4-5H2,1-3H3,(H,17,19)(H,18,20) |
| InChIKey | UNQLSBJKEGXCGH-UHFFFAOYSA-N |
| SMILES | C1(NC(=O)C)=C2C(CCC(NC(=O)C)C2=O)=C(C)C(F)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P304+P340-P305+P351+P338 |
| HS Code | 2924297099 |
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC56926 | N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide ≥95% | 143655-70-3 | 25mg | $282 | 2026-06-04 | Buy |
| Apolloscientific | PC56926 | N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide ≥95% | 143655-70-3 | 50mg | $474 | 2026-06-04 | Buy |
| Apolloscientific | PC56926 | N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide ≥95% | 143655-70-3 | 100mg | $781 | 2026-06-04 | Buy |
| Apolloscientific | PC56926 | N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide ≥95% | 143655-70-3 | 250mg | $1180 | 2026-06-04 | Buy |
| Apolloscientific | PC56926 | N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide ≥95% | 143655-70-3 | 1g | $2735 | 2026-06-04 | Buy |
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide Chemical Properties, Uses, Production
Uses
Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).
IC 50
Camptothecins
References
[1] Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 66)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tekanbio Pharm-Tech Co., Ltd. | 021-50896099 18017206244 | sales@tekanbio.com | China | 88 | 58 |
| Suzhou Zehou Biotechnology Co. , Ltd. | 0512-68716880 19984816880 | sales@growingchem.com | China | 229 | 64 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Zhengzhou Alfachem Co.,Ltd. | 0371-53778726 18003825608 | liuxiaoyan@alfachem.cn | China | 1971 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
View Latest Price from N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
143655-70-3
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
143655-70-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
143655-70-3 (N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide) Related Search:
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1of2
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
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Exatecan Intermediate 5
Exatecan Impurity 8
143655-70-3
