Methyl 3,5-dimethylbenzoate
- CAS No.
- 25081-39-4
- Chemical Name:
- Methyl 3,5-dimethylbenzoate
- Synonyms
- RARECHEM AL BF 0341;Methyl 3,5-dimethylbenzoate;3,5-Dimethylbenzoic acid methyl;Methyl 3,5-dimethylbenzoate 98%;3,5-DIMETHYLBENZOIC ACID METHYL ESTER;Benzoic acid, 3,5-dimethyl-, methyl ester
- CBNumber:
- CB3483961
- Molecular Formula:
- C10H12O2
- Molecular Weight:
- 164.2
- MDL Number:
- MFCD00077971
- MOL File:
- 25081-39-4.mol
- MSDS File:
- SDS
| Melting point | 31-33 °C (lit.) |
|---|---|
| Boiling point | 239-240 °C (lit.) |
| Density | 1.027 g/mL at 25 °C (lit.) |
| refractive index | 1.5160 (estimate) |
| Flash point | 224 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | 1S/C10H12O2/c1-7-4-8(2)6-9(5-7)10(11)12-3/h4-6H,1-3H3 |
| InChIKey | PEVXENGLERTHJE-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc(C)cc(C)c1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2916399090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Methyl 3,5-dimethylbenzoate price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 370215 | Methyl 3,5-dimethylbenzoate 98% | 25081-39-4 | 5g | $30.4 | 2026-04-30 | Buy |
| Apolloscientific | OR907873 | Methyl 3,5-dimethylbenzoate 98% | 25081-39-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR907873 | Methyl 3,5-dimethylbenzoate 98% | 25081-39-4 | 100g | $126 | 2026-06-04 | Buy |
| Apolloscientific | OR907873 | Methyl 3,5-dimethylbenzoate 98% | 25081-39-4 | 500g | $614 | 2026-06-04 | Buy |
| Activate Scientific | AS42191 | Methyl 3,5-dimethylbenzoate 97% | 25081-39-4 | 5g | $23 | 2026-06-04 | Buy |
Methyl 3,5-dimethylbenzoate Chemical Properties, Uses, Production
Uses
Methyl 3,5-dimethylbenzoate may be used in the preparation of four carbon isostere related to highly active 4-pyridinemethanols, which were subsequently evaluated for their antimalarial activity. It may be used in the total synthesis of (±)-indoxamycin B.
General Description
Methyl 3,5-dimethylbenzoate is an aromatic carboxylic acid ester. It was selected as ligand during monomer screening for the synthesis and investigation of various europium compounds containing pinacolyl methylphosphonate with different ligands. Methyl 3,5-dimethylbenzoate is reported as precursor of methyl-3,5-divinylbenzoate.
Synthesis
499-06-9
67-56-1
25081-39-4
Bromobenzene (0.125 g, 0.0081 mol) and 10% palladium carbon (50% wet, 0.2 g) were added to an autoclave with 3,5-dimethylbenzoic acid (1.0 g, 0.0081 mol) and methanol (3 mL). The autoclave was pressurized with nitrogen (1-2 bar) followed by the addition of hydrogen (1-2 bar) and adjusted to the desired hydrogen pressure (5-6 bar). The reaction mixture was heated to 55-60 °C and stirred at 300 rpm for 4 hours. Upon completion of the reaction, the catalyst was filtered through a bed of diatomaceous earth to remove the catalyst. Water (30 mL) was added to the filtrate and the reaction mixture was extracted with isopropyl acetate (2 x 15 mL). The organic layers were combined, washed with 5% aqueous sodium bicarbonate (2 × 15 mL), dried over anhydrous Na2SO4 and filtered. Finally, the filtrate was evaporated by vacuum to give methyl 3,5-dimethylbenzoate product.
References
[1] Helvetica Chimica Acta, 1996, vol. 79, # 7, p. 1967 - 1979
[2] Journal of Organic Chemistry, 2006, vol. 71, # 19, p. 7205 - 7213
[3] Monatshefte fur Chemie, 1996, vol. 127, # 2, p. 185 - 200
[4] European Journal of Organic Chemistry, 2009, # 26, p. 4480 - 4485
[5] Tetrahedron Letters, 2013, vol. 54, # 42, p. 5690 - 5694
Methyl 3,5-dimethylbenzoate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
View Latest Price from Methyl 3,5-dimethylbenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | METHYL 3,5-DIMETHYLBENZOATE
25081-39-4
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- METHYL 3,5-DIMETHYLBENZOATE
25081-39-4
- $6.68
- 97%-99%
- Career Henan Chemical Co
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