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ChemicalBook >> CAS DataBase List >>AZD 5718)

AZD 5718)

AZD 5718) Structure
AZD 5718) structure
CAS No.
2041075-86-7
Chemical Name:
AZD 5718)
Synonyms
Atuliflapon;Unii-NV6352Y6TV;Atuliflapon (AZD5718);Atuliflapon, 10 mM in DMSO;Inhibitor,inhibit,FLAP,AZD-5718,AZD 5718,artery,Atuliflapon,disease,Coronary,5-LO activating protein;(1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide;(1R,2R)-2-(4-(5-Methyl-1H-pyrazol-3-yl)benzoyl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide;Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-
CBNumber:
CB34844513
Molecular Formula:
C24H26N6O3
Molecular Weight:
446.5
MDL Number:
MOL File:
2041075-86-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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AZD 5718) Properties

Boiling point 851.1±65.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
solubility DMSO : 125 mg/mL (279.96 mM; Need ultrasonic)
form Solid
pka 13.12±0.10(Predicted)
color White to off-white
FDA UNII NV6352Y6TV

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

AZD 5718) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RGD07586 AZD5718 2041075-86-7 25mg $1007.75 2026-06-05 Buy
Biosynth RGD07586 AZD5718 2041075-86-7 50mg $1402 2026-06-05 Buy
Biosynth RGD07586 AZD5718 2041075-86-7 100mg $2243 2026-06-05 Buy
ChemScene CS-0090377 Atuliflapon 98.97% 2041075-86-7 5mg $217 2026-06-04 Buy
ChemScene CS-0090377 Atuliflapon 98.97% 2041075-86-7 10mg $347 2026-06-04 Buy
Product number Packaging Price Buy
RGD07586 25mg $1007.75 Buy
RGD07586 50mg $1402 Buy
RGD07586 100mg $2243 Buy
CS-0090377 5mg $217 Buy
CS-0090377 10mg $347 Buy

AZD 5718) Chemical Properties, Uses, Production

Uses

Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease[1].

in vivo

Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively[1].
Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood[1].

References

[1] Daniel Pettersen, et al. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem. 2019 May 9;62(9):4312-4324. DOI:10.1021/acs.jmedchem.8b02004

AZD 5718) Preparation Products And Raw materials

Raw materials

Preparation Products

AZD 5718) Suppliers

Global Suppliers ( 36)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538 cdnovell@163.com China 2445 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Luofa Biochemical Technology Co., Ltd. 021-51111890 15317326293 sales@molnova.com China 4183 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Chengdu Novel Biomedical Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Shanghai Luofa Biochemical Technology Co., Ltd. 58

View Latest Price from AZD 5718) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Atuliflapon pictures 2026-07-27 Atuliflapon
2041075-86-7
 $44.00-158.00 99.28% 10g TargetMol Chemicals Inc.
  • Atuliflapon pictures
  • Atuliflapon
    2041075-86-7
  • $44.00-158.00
  • 99.28%
  • TargetMol Chemicals Inc.

AZD 5718) Spectrum

AZD 5718)(2041075-86-7)1HNMR

2041075-86-7 (AZD 5718)) Related Search:

AZD 5718) Cyclohexanecarboxamide, 2-[4-[3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)- Immunology/Inflammation Compound Library Clinical Compound Library Anti-Cardiovascular disease Compound Library
Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)- Inhibitor,inhibit,FLAP,AZD-5718,AZD 5718,artery,Atuliflapon,disease,Coronary,5-LO activating protein (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide Atuliflapon (AZD5718) Atuliflapon, 10 mM in DMSO (1R,2R)-2-(4-(5-Methyl-1H-pyrazol-3-yl)benzoyl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide Atuliflapon Unii-NV6352Y6TV 2041075-86-7