Caspase-9 Inhibitor
- CAS No.
- 524746-03-0
- Chemical Name:
- Caspase-9 Inhibitor
- Synonyms
- Z-LEHD-FMK TFA;Z-LEHD-FMK(Trifluoroacetate);Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK-TFA
- CBNumber:
- CB34845075
- Molecular Formula:
- C34H44F4N6O12
- Molecular Weight:
- 804.75
- MDL Number:
- MOL File:
- 524746-03-0.mol
- TDS File:
- TDS
Caspase-9 Inhibitor price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA01WT99 | Methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-14-(2-fluoroacetyl)-5-isobutyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate 2,2,2-trifluoroacetate ≥96% | 524746-03-0 | 1mg | $180 | 2026-06-01 | Buy |
| aablocks | AA01WT99 | Methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-14-(2-fluoroacetyl)-5-isobutyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate 2,2,2-trifluoroacetate ≥96% | 524746-03-0 | 2mg | $260 | 2026-06-01 | Buy |
| aablocks | AA01WT99 | Methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-14-(2-fluoroacetyl)-5-isobutyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate 2,2,2-trifluoroacetate ≥96% | 524746-03-0 | 5mg | $520 | 2026-06-01 | Buy |
| aablocks | AA01WT99 | Methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-14-(2-fluoroacetyl)-5-isobutyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate 2,2,2-trifluoroacetate ≥96% | 524746-03-0 | 10mg | $832 | 2026-06-01 | Buy |
| Arctom | SLK-S7313 | Z-LEHD-FMK TFA 99.85% | 524746-03-0 | 2mg | $257 | 2026-05-26 | Buy |
Caspase-9 Inhibitor Chemical Properties, Uses, Production
Uses
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3].
in vivo
Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats[2].
| Animal Model: | Male Wistar albino rats (250-350 g) with SCI[2] |
| Dosage: | 0.8 μmol/kg |
| Administration: | I.v. for 1 or 7 days |
| Result: | Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury. |
IC 50
Caspase-9
References
[1] Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60(22): 6259-65. PMID:11103780
[2] Colak A, et, al. Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg Spine. 2005 Mar; 2(3): 327-34. DOI:10.3171/spi.2005.2.3.0327
[3] Mocanu MM, et, al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May; 130(2): 197-200. DOI:10.1038/sj.bjp.0703336
Caspase-9 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
Caspase-9 Inhibitor Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2436 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| SINO High Goal Chemical Technology Co., Ltd. | 021-57646680 18306277365 | guoxin@chembiobanksh.com | China | 2819 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
