N-CBZ-4-PIPERIDINEACETIC ACID
- CAS No.
- 63845-28-3
- Chemical Name:
- N-CBZ-4-PIPERIDINEACETIC ACID
- Synonyms
- N-CBZ-4-PIPERIDINEACETIC ACID;1-Cbz-4-Piperidineacetic acid;Cbz-1-piperidine-4-acetic acid;1-N-CBZ-4-PIPERIDINEACETIC ACID;2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid;2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid;2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid;4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]-
- CBNumber:
- CB3489882
- Molecular Formula:
- C15H19NO4
- Molecular Weight:
- 277.32
- MDL Number:
- MFCD02179001
- MOL File:
- 63845-28-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)aceticAcid | B194215 | 250mg | $55 |
| N-Cbz-4-piperidineacetic acid | FC140537 | 1g | $74 |
| N-Cbz-4-piperidineacetic acid | FC140537 | 5G | $257 |
| 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 95+% | 119335 | 5g | $432 |
| N-Cbz-4-piperidineacetic acid | FC140537 | 10g | $446.3 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
N-CBZ-4-PIPERIDINEACETIC ACID price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B194215 | 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)aceticAcid | 63845-28-3 | 250mg | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC140537 | N-Cbz-4-piperidineacetic acid | 63845-28-3 | 1g | $74 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC140537 | N-Cbz-4-piperidineacetic acid | 63845-28-3 | 5G | $257 | 2021-12-16 | Buy |
| Matrix Scientific | 119335 | 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 95+% | 63845-28-3 | 5g | $432 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC140537 | N-Cbz-4-piperidineacetic acid | 63845-28-3 | 10g | $446.3 | 2021-12-16 | Buy |
N-CBZ-4-PIPERIDINEACETIC ACID Chemical Properties,Uses,Production
Synthesis
501-53-1
73415-84-6
63845-28-3
For the preparation of 1-Cbz-4-piperidineacetic acid (compound 2), the method was modified as described in DE 4304650 A1. The procedure was as follows: 2-(piperidin-4-yl)acetic acid hydrochloride (3000 mg, 16.7 mmol; Iris Biotech, Marktredwitz, Germany) was dissolved in 46 mL of 1 M NaOH aqueous solution and cooled in an ice bath. Under stirring conditions, benzyloxycarbonyl chloride (Cbz-Cl, 3350 μL, 23.46 mmol, 4002 mg) was slowly added dropwise for a controlled time of 5 min. Subsequently, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the aqueous phase was washed twice with water (20 mL) and a solvent mixture of diethyl ether/petroleum ether (4:1, v/v), and then acidified to pH 1 with aqueous 4 M HCl. The reaction product was extracted with diisopropyl ether (3 × 50 mL). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to give compound 2 as a colorless solid (4383 mg, 15.8 mmol, 95% yield).1H NMR (400 MHz, CDCl3) δ 7.40-7.27 (m, 5H), 5.13 (s, 2H), 4.18 (d, J = 13.3 Hz, 2H), 2.81 ( t, J = 12.8 Hz, 2H), 2.29 (d, J = 7.0 Hz, 2H), 1.96 (tp, J = 11.2, 3.5 Hz, 1H), 1.75 (d, J = 12.1 Hz, 2H), 1.30-1.09 (m, 2H).
References
[1] Patent: WO2014/125084, 2014, A1. Location in patent: Page/Page column 33; 34
[2] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00344; 00345; 00346
N-CBZ-4-PIPERIDINEACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
View Lastest Price from N-CBZ-4-PIPERIDINEACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-06 | N-CBZ-4-PIPERIDINEACETIC ACID
63845-28-3
|
US $1.00 / KG | 1KG | 98% | 10KG | Career Henan Chemical Co |
-
- N-CBZ-4-PIPERIDINEACETIC ACID
63845-28-3
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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