Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-Cbz-4-piperidineacetic acid

N-Cbz-4-piperidineacetic acid

N-Cbz-4-piperidineacetic acid Structure
N-Cbz-4-piperidineacetic acid structure
CAS No.
63845-28-3
Chemical Name:
N-Cbz-4-piperidineacetic acid
Synonyms
1-Cbz-4-Piperidineacetic acid;N-Cbz-4-piperidineacetic acid;Cbz-1-piperidine-4-acetic acid;1-N-CBZ-4-PIPERIDINEACETIC ACID;2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid;2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid;2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid;4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]-
CBNumber:
CB3489882
Molecular Formula:
C15H19NO4
Molecular Weight:
277.32
MDL Number:
MFCD02179001
MOL File:
63845-28-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:05
Request For Quotation

N-Cbz-4-piperidineacetic acid Properties

Boiling point 460.1±28.0 °C(Predicted)
Density 1.216±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 4.66±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

N-Cbz-4-piperidineacetic acid price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 119335 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 63845-28-3 1.00g $144 2026-05-18 Buy
Matrix Scientific 119335 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 63845-28-3 5.00g $432 2026-05-18 Buy
Matrix Scientific 119335 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 63845-28-3 10.00g $720 2026-05-18 Buy
Synthonix B58355 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 95+% 63845-28-3 100mg $12 2026-05-06 Buy
Synthonix B58355 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 95+% 63845-28-3 250mg $16 2026-05-06 Buy
Product number Packaging Price Buy
119335 1.00g $144 Buy
119335 5.00g $432 Buy
119335 10.00g $720 Buy
B58355 100mg $12 Buy
B58355 250mg $16 Buy

N-Cbz-4-piperidineacetic acid Chemical Properties, Uses, Production

Synthesis

Benzyl chloroformate

501-53-1

PIPERIDIN-4-YLACETIC ACID

73415-84-6

N-CBZ-4-PIPERIDINEACETIC ACID

63845-28-3

For the preparation of 1-Cbz-4-piperidineacetic acid (compound 2), the method was modified as described in DE 4304650 A1. The procedure was as follows: 2-(piperidin-4-yl)acetic acid hydrochloride (3000 mg, 16.7 mmol; Iris Biotech, Marktredwitz, Germany) was dissolved in 46 mL of 1 M NaOH aqueous solution and cooled in an ice bath. Under stirring conditions, benzyloxycarbonyl chloride (Cbz-Cl, 3350 μL, 23.46 mmol, 4002 mg) was slowly added dropwise for a controlled time of 5 min. Subsequently, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the aqueous phase was washed twice with water (20 mL) and a solvent mixture of diethyl ether/petroleum ether (4:1, v/v), and then acidified to pH 1 with aqueous 4 M HCl. The reaction product was extracted with diisopropyl ether (3 × 50 mL). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to give compound 2 as a colorless solid (4383 mg, 15.8 mmol, 95% yield).1H NMR (400 MHz, CDCl3) δ 7.40-7.27 (m, 5H), 5.13 (s, 2H), 4.18 (d, J = 13.3 Hz, 2H), 2.81 ( t, J = 12.8 Hz, 2H), 2.29 (d, J = 7.0 Hz, 2H), 1.96 (tp, J = 11.2, 3.5 Hz, 1H), 1.75 (d, J = 12.1 Hz, 2H), 1.30-1.09 (m, 2H).

References

[1] Patent: WO2014/125084, 2014, A1. Location in patent: Page/Page column 33; 34
[2] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00344; 00345; 00346

N-Cbz-4-piperidineacetic acid Preparation Products And Raw materials

Raw materials

Benzyl chloroformate Piperidin-4-ylacetic acid Water Sodium hydroxide

Preparation Products

N-Cbz-4-piperidineacetic acid Suppliers

Global Suppliers ( 90)
Supplier Tel Email Country ProdList Advantage
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2297 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Huainan Kedi Chemical Factory 0554-2106669 sales1@kedichem.com China 4914 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
Supplier Advantage
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Huainan Kedi Chemical Factory 55
Bide Pharmatech Ltd. 60
Chengdu Firster Pharmaceutical Co., Ltd. 60

View Latest Price from N-Cbz-4-piperidineacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-CBZ-4-PIPERIDINEACETIC ACID pictures 2019-08-06 N-CBZ-4-PIPERIDINEACETIC ACID
63845-28-3
 $1.00 1KG 98% 10KG Career Henan Chemical Co

N-Cbz-4-piperidineacetic acid Spectrum

N-CBZ-4-PIPERIDINEACETIC ACID(63845-28-3)1HNMR

63845-28-3 (N-Cbz-4-piperidineacetic acid) Related Search:

1-Boc-piperidin-4-ylidene-acetic acid N-α-Boc-(4-N-Cbz-piperidinyl) glycine 2-Carboxymethyl-piperidine-1-carboxylic acid benzyl ester Methyl N-Cbz-3-piperidineacetate N-Cbz-3-piperidineacetic acid
1-Cbz-4-(2-hydroxy-ethyl)-piperidine N-Cbz-4-piperidineacetic acid Boc-(2S)-Gly-4PIP-Z 4-Methoxycarbonylmethyl-piperidine-1-carboxylic acid benzyl ester 4-(2-Oxo-ethyl)-piperidine-1-carboxylic acid benzyl ester
1-Cbz-4-Piperidine Acetic Acid Ethyl Ester (R)-1-Cbz-3-Piperidineacetic Acid Methyl Ester (S)-1-Cbz-3-Piperidineacetic Acid Methyl Ester

1of3

Cbz-1-piperidine-4-acetic acid 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid 1-N-CBZ-4-PIPERIDINEACETIC ACID 1-Cbz-4-Piperidineacetic acid 4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]- 2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid N-Cbz-4-piperidineacetic acid 63845-28-3 pharmacetical