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ChemicalBook >> CAS DataBase List >>2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Structure
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid structure
CAS No.
111902-57-9
Chemical Name:
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
Synonyms
TEMOCAPRIL;Temocapil;TEMOCAPRIL HCl 99%;TeMocapril USP/EP/BP;Temocapril Impurity 5;Temocapil, 10 mM in DMSO;TEMOCAPRIL DISCONTINUED SEE T017301;Temocapril & Temocapril Hydrochloride;(2E,5E)-2,6-bis(butylamino)-4-hepta-2,5-dienone;2-[(2S)-6-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]-5-keto-2-(2-thienyl)-1,4-thiazepan-4-yl]acetic acid
CBNumber:
CB3501003
Molecular Formula:
C23H28N2O5S2
Molecular Weight:
476.61
MDL Number:
MFCD00865951
MOL File:
111902-57-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Properties

Melting point 1680C
alpha 23 +40° (c = 1.1 in DMF)
Boiling point 717.4±60.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 3.73±0.10(Predicted)
form Powder
color Crystalline
CAS DataBase Reference 111902-57-9(CAS DataBase Reference)
FDA UNII 18IZ008EU6
ATC code C09AA14

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0020063 Temocapril 98.14% 111902-57-9 5mg $32 2026-06-04 Buy
ChemScene CS-0020063 Temocapril 98.14% 111902-57-9 10mg $54 2026-06-04 Buy
ApexBio Technology B2209 Temocapril 111902-57-9 10mg $50 2026-05-06 Buy
ApexBio Technology B2209 Temocapril 111902-57-9 25mg $80 2026-05-06 Buy
aablocks AA007V7J 2-((2S,6R)-6-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)acetic acid ≥97% 111902-57-9 5mg $53 2026-05-28 Buy
Product number Packaging Price Buy
CS-0020063 5mg $32 Buy
CS-0020063 10mg $54 Buy
B2209 10mg $50 Buy
B2209 25mg $80 Buy
AA007V7J 5mg $53 Buy

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Chemical Properties, Uses, Production

Chemical Properties

Crystalline Powder

Uses

Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.

Definition

ChEBI: Temocapril is a dipeptide.

in vivo

Temocapril (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis[3].
Temocapril (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney[4].

Animal Model:Experimental autoimmune myocarditis (EAM) rat model[3]
Dosage:10 mg/kg
Administration:Oral gavage; administration by water; 21 days
Result:Ameliorated EAM and prevented cellular proteins from oxidation.
Enhanced cardiomyocyte redox regulatory protein TRX expression.
Animal Model:Male Sprague Dawley rats[4]
Dosage:30 mg/kg
Administration:Oral gavage, daily, for 4 weeks
Result:Suppressed the blood pressure elevation induced by Ang I.

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Suppliers

Global Suppliers ( 73)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Shanghai Aobo pharmaceutical Technology Co., Ltd 86-21-51320499 aobo@aobopharm.com China 297 57
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9506 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58859352 15955137747 sales01@aikonchem.com China 16021 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
LGM Pharma 70
Shanghai Aobo pharmaceutical Technology Co., Ltd 57
AdooQ BioScience, LLC 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Hubei Jusheng Technology Co.,Ltd 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Aikon International Limited 58

View Latest Price from 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Temocapil pictures 2026-07-27 Temocapil
111902-57-9
 $42.00-67.00 97.80% 10g TargetMol Chemicals Inc.
Temocapril pictures 2020-05-09 Temocapril
111902-57-9
 1KG 99.0% 600 MT Shaanxi Dideu Medichem Co. Ltd
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid pictures 2020-03-06 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
111902-57-9
 $1.00 1KG 99% 200kgs Career Henan Chemical Co
  • Temocapil pictures
  • Temocapil
    111902-57-9
  • $42.00-67.00
  • 97.80%
  • TargetMol Chemicals Inc.
  • Temocapril pictures
  • Temocapril
    111902-57-9
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Spectrum

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid(111902-57-9)1HNMR

111902-57-9 (2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid) Related Search:

CHLORTALIDONE Butenafine hydrochloride 1-(2'-Thienyl)ethylmercaptan Thiophene NICKEL AND VANADIUM IN RESIDUAL FUEL OIL
(2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one Temocaprilat 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Temocapril hydrochloride L-Homophenylalanine ethyl ester
L-β-Homophenylalanine, HPLC 98% 2-Thienylmethanethiol TEMOCAPRIL-D5 (2S,6R)-6-[[1(s)-Ethoxycarbonyl-3-phenylpropyl]amino]-5-oxo-(2-thienyl)perhydro-1,4-thiazepine

1of3

(+)-[(2s,6r)-6-[[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid 2-[(2s)-6-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid (2E,5E)-2,6-bis(butylamino)-4-hepta-2,5-dienone TEMOCAPRIL DISCONTINUED SEE T017301 Temocapil (2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Aci 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- (9CI) 1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, [2S-[2a,6b(R*)]]- 2-((2S,6R)-6-((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-ylamino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)aceticacid [[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid 2-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)-2,5,6,7-tetrahydro-1,4-thiazepine-4(3H)-yl]acetic acid 2-[(2S)-6-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]-5-keto-2-(2-thienyl)-1,4-thiazepan-4-yl]acetic acid 2-[(2S)-6-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid 2-[(2S)-6-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]ethanoic acid Temocapril & Temocapril Hydrochloride TEMOCAPRIL HCl 99% (2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- TeMocapril USP/EP/BP 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid USP/EP/BP Mn-SOD,inhibit,Temocaprilat,Cu/ZnSOD,renal diseases,heart failure,hypertension,Temocapril,insulin resistance,redox proteins TRX,human carboxylesterase,enzyme,acute myocardial infarction,Temocapil,neonatal rat cardiomyocytes,CES1,Angiotensin-converting Enzyme (ACE),angiotensin-converting,Angiotensin (I),N-acetyltetradecapeptide renin substrate,Inhibitor Temocapril Impurity 5 Temocapil, 10 mM in DMSO TEMOCAPRIL 111902-57-9 C23H28N2O5S2 Intermediates & Fine Chemicals Pharmaceuticals