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Temocaprilat

Temocaprilat Structure
Temocaprilat structure
CAS No.
110221-53-9
Chemical Name:
Temocaprilat
Synonyms
Temocaprilate;RS-5139;Temocaprilat;[3H]-Temocaprilat;Temocapril Diacid;Temocapril Impurity 1;TEMOCAPRILAT(FORR&DONLY);Temocaprilat, 10 mM in DMSO;[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid;(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid
CBNumber:
CB6501004
Molecular Formula:
C21H24N2O5S2
Molecular Weight:
448.56
MDL Number:
MFCD00871951
MOL File:
110221-53-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Temocaprilat Properties

Melting point >2300C (dec)
alpha 25D +63.4° (c = 1 in DMF)
Boiling point 743.6±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 2.09±0.10(Predicted)
color White to Off-White
FDA UNII 2D6A12Q12R

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338

Temocaprilat price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22169 Temocaprilat ≥98% 110221-53-9 500μg $134 2026-04-30 Buy
Cayman Chemical 22169 Temocaprilat ≥98% 110221-53-9 1mg $240 2026-04-30 Buy
Cayman Chemical 22169 Temocaprilat ≥98% 110221-53-9 5mg $795 2026-04-30 Buy
Usbiological T2510-06 Temocaprilat (RS-5139) 110221-53-9 1mg $523 2026-06-04 Buy
Matrix Scientific 099570 Temocaprilat 110221-53-9 250.00mg $435 2026-05-18 Buy
Product number Packaging Price Buy
22169 500μg $134 Buy
22169 1mg $240 Buy
22169 5mg $795 Buy
T2510-06 1mg $523 Buy
099570 250.00mg $435 Buy

Temocaprilat Chemical Properties, Uses, Production

Description

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

Chemical Properties

White to Off-White Solid

Uses

Antihypertensive.

Definition

ChEBI: Temocaprilat is a non-proteinogenic alpha-amino acid.

in vivo

Temocaprilat (1 mg/kg/d; i.v.; 4 weeks) significantly reduces systolic blood pressure with time-dependent manner in spontaneously hypertensive (SHR) rats. Temocaprilat improves myocardial fibrosis and oxidative stress in Wistar-Kyoto (WKY) rats and SHR rats[3].

Animal Model:Six 10-week-old WKYs and SHRs and six 50-week-old (aging control) SHRs[3].
Dosage:1 mg/kg/d.
Administration:Intravenous injection; 4 weeks.
Result:Reduced the expression levels of myocardial fibrosis, transforming growth factor-β1 (TGF-β1) mRNA and fibroblast growth factor-2 (FGF-2) mRNA in the left ventricle (LV).
Weakened the expression levels of 8-isoprostane, p22phox mRNA, p47phox mRNA and gp91phox mRNA in LV.

References

[1] KIYOSHI OIZUMI . Pharmacological Profiles of CS-622, a Novel Angiotensin Converting Enzyme Inhibitor[J]. Japanese journal of pharmacology, 1988, 48 3: Pages 349-356. DOI: 10.1254/jjp.48.349

Temocaprilat Preparation Products And Raw materials

Raw materials

Preparation Products

Temocaprilat Suppliers

Global Suppliers ( 61)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shanghai Aobo pharmaceutical Technology Co., Ltd 86-21-51320499 aobo@aobopharm.com China 297 57
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Hubei Yangxin Medical Technology Co., Ltd. 15374522761 3003392093@yongstandards.com China 9995 55
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Shanghai Longsheng chemical Co.,Ltd. 59
Chemsky（shanghai）International Co.,Ltd. 50
Shanghai Aobo pharmaceutical Technology Co., Ltd 57
Quality Control Solutions Ltd. 56
BOC Sciences 65
Hubei Yangxin Medical Technology Co., Ltd. 55
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58

View Latest Price from Temocaprilat manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Temocaprilat pictures 2026-08-20 Temocaprilat
110221-53-9
 $1.10 1g 99.9% Min 100 Tons Dideu Industries Group Limited
Temocaprilat pictures 2026-07-27 Temocaprilat
110221-53-9
 $198.00-418.00 99.31% 10g TargetMol Chemicals Inc.
  • Temocaprilat pictures
  • Temocaprilat
    110221-53-9
  • $1.10
  • 99.9% Min
  • Dideu Industries Group Limited
  • Temocaprilat pictures
  • Temocaprilat
    110221-53-9
  • $198.00-418.00
  • 99.31%
  • TargetMol Chemicals Inc.

Temocaprilat Spectrum

Temocaprilat(110221-53-9)1HNMR

110221-53-9 (Temocaprilat) Related Search:

Tetrahydrothiophene Aminoethoxyvinyl glycine hydrochloride Glycine Tris(hydroxymethyl)aminomethane 2-Aminophenol
Thifensulfuron Cephalothin sodium 1,1'-Carbonyldiimidazole 6-Aminocaproic acid Temocapril hydrochloride
Carbonyl iron powder 2-Thienylmethanethiol (2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid TEMOCAPRIL-D5
L-β-Homophenylalanine, HPLC 98% 1-(2'-Thienyl)ethylmercaptan Amino acids

1of4

[3H]-Temocaprilat RS-5139 TEMOCAPRILAT(FORR&DONLY) (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid [[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Temocapril Diacid Temocaprilate Temocaprilat 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- Temocapril Impurity 1 Temocaprilat, 10 mM in DMSO 110221-53-9 C21H24N2O5S2 Intermediates & Fine Chemicals Pharmaceuticals