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Temocaprilat

Temocaprilat structure

CAS No.: 110221-53-9

Chemical Name:: Temocaprilat

Synonyms: Temocaprilate;RS-5139;Temocaprilat;[3H]-Temocaprilat;Temocapril Diacid;Temocapril Impurity 1;TEMOCAPRILAT(FORR&DONLY);Temocaprilat, 10 mM in DMSO;[[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid;(2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid

CBNumber:: CB6501004

Molecular Formula:: C21H24N2O5S2

Molecular Weight:: 448.56

MDL Number:: MFCD00871951

MOL File:: 110221-53-9.mol

MSDS File:: SDS

Last updated:2025-04-29 09:03:59

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Temocaprilat Properties

Melting point	>2300C (dec)
alpha	25D +63.4° (c = 1 in DMF)
Boiling point	743.6±60.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.09±0.10(Predicted)
color	White to Off-White
FDA UNII	2D6A12Q12R

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338

Temocaprilat price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22169	Temocaprilat	110221-53-9	500μg	$121	2024-03-01	Buy
Cayman Chemical	22169	Temocaprilat	110221-53-9	1mg	$218	2024-03-01	Buy
Cayman Chemical	22169	Temocaprilat	110221-53-9	5mg	$722	2024-03-01	Buy
TRC	T017305	Temocaprilat	110221-53-9	1g	$1015	2021-12-16	Buy
AK Scientific	O437	Temocaprilat	110221-53-9	1g	$1366	2021-12-16	Buy

Product number	Packaging	Price	Buy
22169	500μg	$121	Buy
22169	1mg	$218	Buy
22169	5mg	$722	Buy
T017305	1g	$1015	Buy
O437	1g	$1366	Buy

Temocaprilat Chemical Properties,Uses,Production

Description

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀ = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I with an IC₅₀ value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

Chemical Properties

White to Off-White Solid

Uses

Antihypertensive.

Definition

ChEBI: Temocaprilat is a non-proteinogenic alpha-amino acid.

in vivo

Temocaprilat (1 mg/kg/d; i.v.; 4 weeks) significantly reduces systolic blood pressure with time-dependent manner in spontaneously hypertensive (SHR) rats. Temocaprilat improves myocardial fibrosis and oxidative stress in Wistar-Kyoto (WKY) rats and SHR rats^[3].

Animal Model:	Six 10-week-old WKYs and SHRs and six 50-week-old (aging control) SHRs^[3].
Dosage:	1 mg/kg/d.
Administration:	Intravenous injection; 4 weeks.
Result:	Reduced the expression levels of myocardial fibrosis, transforming growth factor-β1 (TGF-β1) mRNA and fibroblast growth factor-2 (FGF-2) mRNA in the left ventricle (LV). Weakened the expression levels of 8-isoprostane, p22phox mRNA, p47phox mRNA and gp91phox mRNA in LV.

Temocaprilat Preparation Products And Raw materials

Raw materials

Preparation Products

Temocaprilat Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32281	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30230	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22866	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
PT CHEM GROUP LIMITED	+86-85511178; +86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49980	58
J & K SCIENTIFIC LTD.	18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Longsheng chemical Co.,Ltd.	021-58099652-8005 13585536065	bin.wu@shlschem.com	China	9810	59

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
J & K SCIENTIFIC LTD.	76
Shanghai Longsheng chemical Co.,Ltd.	59

View Lastest Price from Temocaprilat manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-29	Temocaprilat 110221-53-9	US $198.00-418.00 / mg		96.88%	10g	TargetMol Chemicals Inc.
	2022-05-17	Temocaprilat 110221-53-9	US $1.10 / g	1g	99.9% Min	100 Tons	Dideu Industries Group Limited

Temocaprilat
110221-53-9
US $198.00-418.00 / mg
96.88%
TargetMol Chemicals Inc.

Temocaprilat
110221-53-9
US $1.10 / g
99.9% Min
Dideu Industries Group Limited

110221-53-9(Temocaprilat)Related Search:

2-Aminophenol Glycine Thifensulfuron Cephalothin sodium Tris(hydroxymethyl)aminomethane

1,1'-Carbonyldiimidazole 6-Aminocaproic acid ALTRENOGEST Tetrahydrothiophene Temocapril hydrochloride

(2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one 2-Thiophenemethanethiol Carbonyl iron powder 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid L-β-Homophenylalanine, HPLC 98%

TEMOCAPRIL-D5 1-(2'-THIENYL)ETHYLMERCAPTAN Temocaprilat

1of4

[3H]-Temocaprilat RS-5139 TEMOCAPRILAT(FORR&DONLY) (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid [[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Temocapril Diacid Temocaprilate Temocaprilat 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- Temocapril Impurity 1 Temocaprilat, 10 mM in DMSO 110221-53-9 C21H24N2O5S2 Intermediates & Fine Chemicals Pharmaceuticals