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Docetaxel trihydrate

Docetaxel trihydrate Structure
Docetaxel trihydrate structure
CAS No.
148408-66-6
Chemical Name:
Docetaxel trihydrate
Synonyms
DOCETAXEL HYDRATE;Xrp6976;Taxespira;Unii-15H5577cqd;Docetaxel (200 mg);Taxotere Trihydrate;Docetaxel (1224551);Docetaxel trihydrate;Docetaxel Tryhydrate;Docetaxel(trihydrous)
CBNumber:
CB3511420
Molecular Formula:
C43H55NO15
Molecular Weight:
825.91
MDL Number:
MOL File:
148408-66-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Docetaxel trihydrate Properties

Melting point 186-192°C
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
form Solid
color White to OFf-White
Stability Hygroscopic
InChIKey XCDIRYDKECHIPE-KHDBCEGQSA-N
CAS DataBase Reference 148408-66-6(CAS DataBase Reference)
FDA UNII 15H5577CQD

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Danger
Hazard statements  H319-H360F
Precautionary statements  P202-P264-P280-P305+P351+P338-P308+P313-P337+P313
WGK Germany  3
HS Code  2932996560

Docetaxel trihydrate price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001155 Docetaxel for system suitability European Pharmacopoeia (EP) Reference Standard 148408-66-6 15 mg $167 2026-04-30 Buy
Sigma-Aldrich Y0001133 Docetaxel trihydrate European Pharmacopoeia (EP) Reference Standard 148408-66-6 160 mg $254 2026-04-30 Buy
Sigma-Aldrich PHR1883 Docetaxel trihydrate 148408-66-6 200mg $398 2026-04-30 Buy
Sigma-Aldrich 1224551 Docetaxel for system suitability 148408-66-6 200mg $3270 2026-04-30 Buy
Biosynth FD29606 Docetaxel trihydrate 148408-66-6 0.25g $240.21 2026-06-04 Buy
Product number Packaging Price Buy
Y0001155 15 mg $167 Buy
Y0001133 160 mg $254 Buy
PHR1883 200mg $398 Buy
1224551 200mg $3270 Buy
FD29606 0.25g $240.21 Buy

Docetaxel trihydrate Chemical Properties, Uses, Production

Pharmacology

Docetaxel principally exerts its cytotoxic activity by promoting and stabilising microtubule assembly while simultaneously preventing microtubule depolymerisation. This results in inhibition of normal cell division. In vitro and in vivo, docetaxel has antineoplastic activity against a wide range of cancer cells, demonstrates synergistic activity with several antineoplastic agents and often has greater cytotoxic activity against human breast cancer cell lines than paclitaxel. Docetaxel, binds to and stabilizes tubulin, which prevents physiological microtubule depolymerization/disassembly and results in cell-cycle arrest at the G2/M phase and cell death. This agent also is known to inhibit the anti-apoptotic gene Bcl2 and to encourage the expression of p27, a cell-cycle inhibitor, and further pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes, and its clearance has been shown to be related to body surface area and hepatic enzyme and alpha1 acid glycoprotein plasma levels.

Tolerability

The tolerability of docetaxel in comparative clinical trials was generally acceptable. Severe neutropenia affects most docetaxel recipients, with febrile neutropenia occurring in approximately one-eighth of patients. Dose-cumulative severe fluid retention was reported in docetaxel recipients, despite premedication with prophylactic corticosteroids. Other adverse events include asthenia, stomatitis, infections, neurosensory, cutaneous or gastrointestinal events, nail changes, severe fever in the absence of infection, myalgia and hypersensitivity reactions.

Chemical Properties

White Crystalline Powder

Uses

An antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin

Uses

Docetaxel Trihydrate is an anti-cancer drugs; Semisynthetic analog of the taxane paclitaxel.

Definition

ChEBI: The trihydrate form of docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.

brand name

Taxotere (Sanofi Aventis).

in vivo

In female mice, the Docetaxel Trihydrate (RP-56976 Trihydrate)-induced intestinal apoptosis in the 14-hours after light on (HALO) group is significantly greater than that in the 2-HALO group. Bax expression is significantly elevated by Docetaxel in the 2-HALO group, but not in the 14-HALO group. On the other hand, cleaved Caspase-3 expression is significantly elevated by Docetaxel in the 14-HALO group, but not in the 2-HALO group. The expressions of Wee1 and phosphorylated CKD1 are significantly elevated after dosing of Docetaxel at 14 HALO, but not at 2 HALO. In addition, Docetaxel significantly reduces survivin expression in the 14-HALO group but not in the 2-HALO group. The survivin expression level in the Docetaxel-treated 14-HALO group is significantly smaller than that in the drug-treated 2-HALO group[3]. Piperine (PIP) is administrated via intravenous bolus at 3.5 mg/kg and via oral administration at 35 mg/kg and 3.5 mg/kg, while Docetaxel (DOX) is intravenously administrated at 7 mg/kg to Sprague-Daley rats. The co-administrations of PIP at 35 mg/kg via oral administration and Docetaxel at 7 mg/kg via intravenous bolus administration in Sprague-Dawley rats. The combination use of PIP and Docetaxel results in a synergic increase of both their in vivo exposure[4].

Docetaxel trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Docetaxel trihydrate Suppliers

Global Suppliers ( 312)
Supplier Tel Email Country ProdList Advantage
Hefei NaNo Biological Technology Co., Ltd. 0551-65629887 18010855303 sales@hfnhsw.com China 268 58
Jiangsu Yew Pharmaceutical Co., Ltd. 18921335032 China 66 58
Guangzhou Tomums Life Science Co., Ltd. 020-31155029 18902330969 sales@tomums.cn China 4688 58
Fujian South Pharmaceutical Co., Ltd. 0598-2860412 779237949 salesone@southpharma.com China 42 55
Taizhou Creating Bio-pharm Co.,Ltd. +86-0576-88827176 +86-18906581668 post@creatingchemical.com China 220 58
Jinan Good Medical &Technology Ltd Co., +86-0086-531-55562571，18953105926 13553167512 935170726@qq.com China 41 58
Fujian Huayao Pharmaceutical Technology Co., Ltd. 18559985626 liujie@fjhypharma.com China 18 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
Hefei NaNo Biological Technology Co., Ltd. 58
Jiangsu Yew Pharmaceutical Co., Ltd. 58
Guangzhou Tomums Life Science Co., Ltd. 58
Fujian South Pharmaceutical Co., Ltd. 55
Taizhou Creating Bio-pharm Co.,Ltd. 58
Jinan Good Medical &Technology Ltd Co., 58
Fujian Huayao Pharmaceutical Technology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Jia Xing Isenchem Co.,Ltd 66

Related articles

  • What is Docetaxel trihydrate?
  • Docetaxel (Taxotere?), a cytotoxic taxane, is an antimicrotubule agent effective in the treatment of patients with breast canc....
  • Feb 10,2020

View Latest Price from Docetaxel trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Docetaxel Trihydrate pictures 2026-09-18 Docetaxel Trihydrate
148408-66-6
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Docetaxel Trihydrate pictures 2026-08-25 Docetaxel Trihydrate
148408-66-5
 1KG 0.99 1000KG Shaanxi Xianhe Biotech Co., Ltd
Docetaxel trihydrate pictures 2026-07-27 Docetaxel trihydrate
148408-66-6
 $46.00 99.84% 10g TargetMol Chemicals Inc.

Docetaxel trihydrate Spectrum

Docetaxel trihydrate(148408-66-6)1HNMR

148408-66-6 (Docetaxel trihydrate) Related Search:

Docetaxel Docetaxel (2R,3S)-Boc-3-Phenylisoserine Methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
Paclitaxel Docetaxel Impurity 5 2-Debenzoyl-2-pentenoyl Docetaxel 13-O-(Triethylsilyl) Baccatin III 10-Oxo Docetaxel
Docetaxel Metabolite M4 TYRPHOSTIN AG 1024 AVP-AEW541 NOCODAZOLE (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Crizotinib Olaparib Docetaxel Impurity 15

1of4

(αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11- Docetaxel/Docetaxel Trihydrate Docetaxel (200 mg) Taxotere Trihydrate (αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,hydrate (1:3) RP56976 (NSC 628503) Trihydrate Docetaxel(trihydrous) (2AR,4S,4aS,6R,9S,11S,12S,12aS,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2- Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2ar,4S,4as,6R,9S,11S,12S,12ar,12bs)-12B-(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,6,11-trihydroxy-4A,8,1313-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-yl ester, trihydrate, (alphar,betas)- Unii-15H5577cqd Xrp6976 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv. Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyc Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]- Docetaxel trihydrate Docetaxel for system suitability CRS Docetaxel trihydrate CRS RP-56976 (Trihydrate) (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate trihydrate Docetaxel Trihydrate DISCONTINUED PLEASE SEE D494420 Docetaxel Trihydrate (RP 56976) Docetaxel for system suitability (Y0001155) Docetaxel TrihydrateQ: What is Docetaxel Trihydrate Q: What is the CAS Number of Docetaxel Trihydrate Q: What is the storage condition of Docetaxel Trihydrate Q: What are the applications of Docetaxel Trihydrate Docetaxel (1224551) Taxespira (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca3,4benzo1,2-boxet-12-yl benzoate trihydrate Docetaxel Tryhydrate Docetaxel (200 mg) ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5Beta,20-epoxy-1,2alpha,4,7Beta,10Beta,13alpha-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate) Docetaxel trihydrate, 10 mM in DMSO Docetaxel trihydrate - Bio-X ? DOCETAXEL HYDRATE 148408-66-6 14848-66-6 C43H59NO17 C43H53NO143H2O C43H59NO7 Anticancer Plant extracts Herb extract TAXOTERE Anti-cancer&immunity Plant extract Inhibitors Intermediates & Fine Chemicals Pharmaceuticals All Inhibitors