Kira8 Hydrochloride
- CAS No.
- 2250019-92-0
- Chemical Name:
- Kira8 Hydrochloride
- Synonyms
- Kira8 Hydrochloride;AMG-18 Hydrochloride;Kira8 Hydrochloride,Kira-8 Hydrochloride;KIRA8 HYDROCHLORIDE (AMG-18 HYDROCHLORIDE);(S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide hydrochloride
- CBNumber:
- CB35540391
- Molecular Formula:
- C31H29ClN6O3S.ClH
- Molecular Weight:
- 637.58
- MDL Number:
- MFCD31656706
- MOL File:
- 2250019-92-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Kira8 Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 43488 | AMG 18 (hydrochloride) ≥98% | 1mg | $76 | 2026-04-30 | Buy | |
| Cayman Chemical | 43488 | AMG 18 (hydrochloride) ≥98% | 5mg | $285 | 2026-04-30 | Buy | |
| Cayman Chemical | 43488 | AMG 18 (hydrochloride) ≥98% | 10mg | $418 | 2026-04-30 | Buy | |
| Cayman Chemical | 43488 | AMG 18 (hydrochloride) ≥98% | 25mg | $950 | 2026-04-30 | Buy | |
| Biosynth | AQD01992 | AMG 18 hydrochloride | 2250019-92-0 | 10mg | $1139.8 | 2026-06-04 | Buy |
Kira8 Hydrochloride Chemical Properties, Uses, Production
Uses
Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].
in vivo
Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks[1].
One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs[1].
| Animal Model: | Male Ins2+/Akita mice[1] |
| Dosage: | 50 mg/kg |
| Administration: | Injected i.p.; daily; for 35 days |
| Result: | Significant reduction of hyperglycemia became apparent over several weeks. |
storage
Store at -20°C
References
[1] Morita S, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25(4):883-897.e8. DOI:10.1016/j.cmet.2017.03.018
Kira8 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Kira8 Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 992 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
View Latest Price from Kira8 Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Kira8 Hydrochloride
2250019-92-0
|
$1130.00 | 10g | TargetMol Chemicals Inc. |
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- Kira8 Hydrochloride
2250019-92-0
- $1130.00
- TargetMol Chemicals Inc.
