QTX125
- CAS No.
- 1279698-31-5
- Chemical Name:
- QTX125
- Synonyms
- QTX125;QTX125,QTX-125;1H-Pyrrole-2-carboxamide, 3-(3-furanyl)-N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-5-(4-hydroxyphenyl)-
- CBNumber:
- CB35867313
- Molecular Formula:
- C23H19N3O5
- Molecular Weight:
- 417.41
- MDL Number:
- MFCD34469284
- MOL File:
- 1279698-31-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
QTX125 Chemical Properties, Uses, Production
Uses
QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].
in vivo
QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].
| Animal Model: | Nude mice bearing REC-1 or MINO cells[1] |
| Dosage: | 60 mg/kg |
| Administration: | Intraperitoneal administration; daily dosing for 5 days; for 4 weeks |
| Result: | Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice. |
IC 50
HDAC6
References
[1] Montserrat Pérez-Salvia, et al. In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Haematologica. 2018 Nov;103(11):e537-e540. DOI:10.3324/haematol.2018.189241
QTX125 Preparation Products And Raw materials
Raw materials
Preparation Products
QTX125 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
