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ChemicalBook >> CAS DataBase List >>5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Structure
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- structure
CAS No.
1263871-36-8
Chemical Name:
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-
Synonyms
BMS-932481;BMS-932481(BMS932481;5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-
CBNumber:
CB35923569
Molecular Formula:
C24H24FN7O
Molecular Weight:
445.49
MDL Number:
MOL File:
1263871-36-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-21 11:20:27
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5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Properties

FDA UNII 9W144SV55B

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Chemical Properties, Uses, Production

Uses

BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively[1].

in vivo

BMS-932481 (2-30 mg/kg, po, single dose) reduces the levels of Aβ1-42 and Aβ1-40, increases levels of Aβ1-38 and Aβ1-37, without changing overall amounts of Aβ peptides in dog models[1].
BMS-932481 (2.5-15 mg/kg, iv, single dose) exhibits moderate brain penetration with brain-to-plasma ratio and AUCbrain to AUCplasma ratio of about 0.23 and 0.6 in Sprague-Dawley rats[1].

Animal Model:Beague dog model[1]
Dosage:2-30 mg/kg
Administration:po, single dose
Result:Reduced levels of Aβ1-42 and Aβ1- 40 of 65% with 30 mg/kg dose, increased levels of Aβ1-38 and Aβ1-37 by 1.8 and 5 fold.

References

[1] Toyn JH, et al., Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. DOI:10.1124/jpet.116.232249

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Preparation Products And Raw materials

Raw materials

Preparation Products

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BMS-932481 pictures 2026-04-21 BMS-932481
1263871-36-8
 $2120.00-3700.00 10g TargetMol Chemicals Inc.
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    1263871-36-8
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1263871-36-8 (5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-) Related Search:

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- MRK 560 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid 2H-1,2,4-Oxadiazine, 5-(4-chlorophenyl)-6-cyclopropyl-5,6-dihydro-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-, (5R,6S)-rel-(+)- RO7185876
Dibenzazepine

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5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- BMS-932481 BMS-932481(BMS932481 1263871-36-8