K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb
- CAS No.
- Chemical Name:
- K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb
- Synonyms
- K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb
- CBNumber:
- CB36259779
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
All
Background
Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue. The ubiquitin-proteasome pathway has been implicated in a wide range of normal biological processes and in disease-related abnormalities. Several proteins such as IκB, p53, cdc25A, and Bcl-2 have been shown to be targets for the ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis.Substrate proteins are linked to ubiquitin using seven distinct ubiquitin lysine residues. Formation of a polyubiquitin chain occurs when a lysine residue of ubiquitin is linked to the carboxy-terminal glycine of another ubiquitin. Proteins polyubiquitinated at specific lysine residues display a tendency to be targeted for different processes. K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development.
References
[1] Ciechanover, A. (1998) EMBO J 17, 7151-60.
[2] Hochstrasser, M. (2000) Nat Cell Biol 2, E153-7.
[3] Hochstrasser, M. (2000) Science 289, 563-4.
[4] Bernardi, R. et al. (2000) Oncogene 19, 2447-54.
[5] Aberle, H. et al. (1997) EMBO J 16, 3797-804.
[6] Salomoni, P. and Pandolfi, P.P. (2002) Nat Cell Biol 4, E152-3.
[7] Jesenberger, V. and Jentsch, S. (2002) Nat Rev Mol Cell Biol 3, 112-21.
[8] Komander, D. (2009) Biochem Soc Trans 37, 937-53.
[9] Chen, Z.J. and Sun, L.J. (2009) Mol Cell 33, 275-86.
[10] Yang, W.L. et al. (2010) Oncogene 29, 4493-503.
K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb Preparation Products And Raw materials
Raw materials
Preparation Products
K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
