Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb
- CAS No.
- Chemical Name:
- Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb
- Synonyms
- Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb
- CBNumber:
- CB86265986
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human
Background
Gasdermin D, a member of the gasdermin family that includes GSDMA, GSDMB, and GSDMC, has been reported to have a critical role as a downstream effector of pyroptosis. Pyroptosis is a lytic type of cell death triggered by inflammasomes, multiprotein complexes assembled in response to pathogen-associated molecular patterns or danger-associated molecular patterns that result in the activation of caspase-1 and subsequent cleavage of pro-inflammatory cytokines IL-1β and IL-18. Gasdermin D was identified by two independent groups as a substrate of inflammatory caspases, caspase-1 and caspase-11/4/5, producing two fragments: GSDMD-N and GSDMD-C. Cleavage results in release of an intramolecular inhibitory interaction between the N- and C-terminal domains, allowing the N-terminal fragment GSDMD-N to initiate pyroptosis through the formation of pores on the plasma membrane.
References
[1] Kayagaki, N. et al. (2015) Nature 526, 666-71.
[2] Shi, J. et al. (2015) Nature 526, 660-5.
[3] Broz, P. and Dixit, V.M. (2016) Nat Rev Immunol 16, 407-20.
[4] Aglietti, R.A. et al. (2016) Proc Natl Acad Sci U S A 113, 7858-63.
[5] Ding, J. et al. (2016) Nature 535, 111-6.
[6] Liu, X. et al. (2016) Nature 535, 153-8.
[7] Sborgi, L. et al. (2016) EMBO J 35, 1766-78.
Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb Preparation Products And Raw materials
Raw materials
Preparation Products
Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
