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(D-Ala2)-Leu-Enkephalin

(D-Ala2)-Leu-Enkephalin structure

CAS No.: 64963-01-5

Chemical Name:: (D-Ala2)-Leu-Enkephalin

Synonyms: (D-ALA2)-LEU-ENKEPHALIN;TYR-D-ALA-GLY-PHE-LEU;D-ALA2-LEU5-ENKEPHALIN;(D-Ala)-Leu-Enkephalin;Pentapeptide-18 Peptide;Tyr-D-Ala-Gly-Phe-Leu-OH;Pentapeptide-3/Leuphasyl;H-TYR-D-ALA-GLY-PHE-LEU-OH;Leuphasyl / Pentapeptide-3;[D-ALA2]-LEUCINE ENKEPHALIN

CBNumber:: CB3667734

Molecular Formula:: C29H39N5O7

Molecular Weight:: 569.65

MDL Number:: MFCD00076409

MOL File:: 64963-01-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

Product description	Number	Pack Size	Price
[D-Ala2]-Leucine enkephalin ≥97% (HPLC)	E5008	5mg	$113
(D-Ala2)-Leu-Enkephalin	FA108766	50mg	$900
(D-Ala2)-Leu-Enkephalin	FA108766	25mg	$900
(D-Ala2)-Leu-Enkephalin	FA108766	10mg	$900
(D-Ala2)-Leu-Enkephalin	FA108766	100mg	$1027
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(D-Ala2)-Leu-Enkephalin Properties

Melting point	160-163.5 °C
Boiling point	991.9±65.0 °C(Predicted)
Density	1.257±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMF (Slightly), DMSO (Slightly)
pka	3.40±0.10(Predicted)
form	Solid
color	White to Off-White
Sequence	Tyr-{d-Ala}-Gly-Phe-Leu
InChIKey	ZHUJMSMQIPIPTF-JMBSJVKXSA-N
SMILES	C(O)(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N
FDA UNII	PO4D55T1IG
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
Storage Class	11 - Combustible Solids

(D-Ala2)-Leu-Enkephalin price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E5008	[D-Ala2]-Leucine enkephalin ≥97% (HPLC)	64963-01-5	5mg	$113	2026-04-30	Buy
Biosynth	FA108766	(D-Ala2)-Leu-Enkephalin	64963-01-5	50mg	$900	2026-06-04	Buy
Biosynth	FA108766	(D-Ala2)-Leu-Enkephalin	64963-01-5	25mg	$900	2026-06-04	Buy
Biosynth	FA108766	(D-Ala2)-Leu-Enkephalin	64963-01-5	10mg	$900	2026-06-04	Buy
Biosynth	FA108766	(D-Ala2)-Leu-Enkephalin	64963-01-5	100mg	$1027	2026-06-04	Buy

Product number	Packaging	Price	Buy
E5008	5mg	$113	Buy
FA108766	50mg	$900	Buy
FA108766	25mg	$900	Buy
FA108766	10mg	$900	Buy
FA108766	100mg	$1027	Buy

(D-Ala2)-Leu-Enkephalin Chemical Properties,Uses,Production

Uses

[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

Definition

The leucine-enkephalin (Tyr-Gly-Gly-Phe-Leu, Leu-enk) is a natural endogenous ligand for opiate receptors. Leu-enk is rapidly metabolized in vivo and in vitro[1]. (D-Ala2)-Leu-Enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

benefits

(D-Ala2)-Leu-Enkephalin is widely distributed in the human body and has essential physiological functions. It has a unique effect on brain cells and can activate sleeping brain cells and have a good recovery effect on the sequelae caused by brain damage. It plays an important role in immune function, including increasing the activity of the immune system, T lymphocytes, NK cells, macrophages, antiviral, and the release of gamma interferon. It can participate in immune regulation by promoting the secretion of endocrine cells by activated immune cells, thereby affecting DNA's gene regulation and expression functions.

IC 50

δ Opioid Receptor/DOR

References

[1] H. Hasegawa, S. Baba, Y. Shinohara. “Synthesis of [D-Ala2]Leu-enkephalin and [D-Ala2, D-Leu5]Leu-enkephalin with high specific tritiated activity in the leucine residue.” Journal of The Chemical Society-perkin Transactions 1 12 1 (1990): 2641–2644.

(D-Ala2)-Leu-Enkephalin Preparation Products And Raw materials

Raw materials

Preparation Products

(D-Ala2)-Leu-Enkephalin Suppliers

Global( 234)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Sichuan Hantongkuntai Biotechnology Co., LTD.	18981903347	Hantongkuntai@foxmail.com	China	235	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	278	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8737	58
Shanghai Yunao International Trade Co., Ltd	+86-17621705551	asdf@shanghaihg.cn	China	262	58
HR Biotechnology Co.,Ltd	+86-1 +86-1	1	China	110	58
Nantong Guangyuan Chemicl Co,Ltd	+86-17331189928	admin@guyunchem.com	China	611	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-17782035140	sales@zhswyy.com	China	263	58
Shanghai Affida new material science and technology center	+86-15081010295	admin@oudaxin.com	China	112	58
Shaanxi TNJONE Pharmaceutical Co., Ltd		sarah@tnjone.com	China	1139	58

Supplier	Advantage
Cellmano Biotech Limited	58
Sichuan Hantongkuntai Biotechnology Co., LTD.	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shanghai Yunao International Trade Co., Ltd	58
HR Biotechnology Co.,Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Shanghai Affida new material science and technology center	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58

View Lastest Price from (D-Ala2)-Leu-Enkephalin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-13	Pentapeptide-18 64963-01-5		1g	99%	1kg	Xi an Biohorlden Industry Trade Co Ltd
2026-08-09	(D-Ala2)-Leu-Enkephalin 64963-01-5			99%	2000kgs	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2026-07-15	[D-Ala2]leucine-enkephalin 64963-01-5	$57.00-178.00		98.06%	10g	TargetMol Chemicals Inc.

Pentapeptide-18
64963-01-5
99%
Xi an Biohorlden Industry Trade Co Ltd

(D-Ala2)-Leu-Enkephalin
64963-01-5
99%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

[D-Ala2]leucine-enkephalin
64963-01-5
$57.00-178.00
98.06%
TargetMol Chemicals Inc.

(D-Ala2)-Leu-Enkephalin Spectrum

(D-Ala2)-Leu-Enkephalin(64963-01-5)¹HNMR

64963-01-5((D-Ala2)-Leu-Enkephalin)Related Search:

Acetyl Octapeptide-3 PALMITOYL TETRAPEPTIDE-3 Palmitoyl Pentapeptide Palmitoyl Tripeptide-5 Acetyl Tetrapeptide-5

NONAPEPTIDE-1 PALMITOYL TRIPEPTIDE-1 Lipopeptide Acetate Palmitoyl Pentapeptide-3 Matrixyl，PALMITOYL PENTAPEPTIDE-3

TYR-D-ALA-GLY-PHE-MET ACOH H2O Hexapeptide 9 HEXAPEPTIDE-3 Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Pentapeptide-25

Aprotinin (D-Ala2)-Leu-Enkephalin H-TYR-D-ALA-GLY-PHE-LEU-ARG-ARG-ILE-ARG-OH

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H-TYR-D-ALA-GLY-PHE-LEU-OH (D-ALA2)-LEU-ENKEPHALIN D-ALA2-LEU5-ENKEPHALIN [D-ALA2]-LEUCINE ENKEPHALIN TYR-D-ALA-GLY-PHE-LEU N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine (D-alanine2)leucine enkephalin L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH (D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH (D-Ala)-Leu-Enkephalin [D-ALA2]LEUCINE-ENKEPHALIN, >99% [D-Ala2]leucine-enkephalin,Tyr-D-Ala-Gly-Phe-Leu, >99% Tyr-D-Ala-Gly-Phe-Leu-OH 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-valeric acid 2-[[2-[2-[2-[[2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid [D-Ala2]-Leucine enkephalin,Tyr-D-Ala-Gly-Phe-Leu Pentapeptide-3/Leuphasyl L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine Tyrosyl-D-alanylglycylphenylalanylleucine Leuphasyl / Pentapeptide-3 Leuphasyl / Pentapeptide-18 Pentapeptide-18/Leuphasyl with reduce facial muscle L-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl- 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoicaci TYR-D-ALA-GLY-PHE-LEU USP/EP/BP Lab Supply High Purity Pentapeptide-18 Powder CAS 64963-01-5 with Best Price Pentapeptide-18 Peptide 64963-01-5 C29H39N5O7 Enkephalins Opioid Peptides Peptides Biochemicals and Reagents Amino Acids and Peptides BioChemical