Acetyl Tetrapeptide-5
- CAS No.
- 820959-17-9
- Chemical Name:
- Acetyl Tetrapeptide-5
- Synonyms
- tetrapeptide;Acetyl Tetrapeptide;Depuffin;Ac-β-Ala-His-Ser-His;cetyl Tetrapeptide-5;Acetyl tetrapeptide-5;Tetrapeptide /Eyeseryl;Ac-βAla-His-Ser-His-OH;N-Ac-β-Ala-His-Ser-His;Eyeseryl WIPO、? Eyeseryl
- CBNumber:
- CB42489935
- Molecular Formula:
- C20H28N8O7
- Molecular Weight:
- 492.49
- MDL Number:
- MFCD30179524
- MOL File:
- 820959-17-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1237.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.443 |
| storage temp. | 2-8°C |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| pka | 2.76±0.10(Predicted) |
| color | White to off-white |
| Sequence | Ac-β-{Ala}-His-Ser-His-OH |
| Cosmetics Ingredients Functions | HUMECTANT |
| InChIKey | RIUMNDWYYDHBFO-UDJPXWLSNA-N |
| SMILES | C(O)(=O)[C@H](CC1N=CN=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1N=CN=C1)NC(=O)CCNC(C)=O |&1:3,13,19,r| |
| EWG's Food Scores | 1 |
| FDA UNII | Y1DFQ308G8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Acetyl Tetrapeptide-5 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27152 | Acetyl Tetrapeptide-5 ≥98% | 820959-17-9 | 250mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 27152 | Acetyl Tetrapeptide-5 ≥98% | 820959-17-9 | 500mg | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 27152 | Acetyl Tetrapeptide-5 ≥98% | 820959-17-9 | 1g | $477 | 2026-04-30 | Buy |
| ChemPep | 180329-5G | Acetyl Tetrapeptide-5 | 820959-17-9 | 5g | $850 | 2026-06-04 | Buy |
| ChemPep | 180329-25G | Acetyl Tetrapeptide-5 | 820959-17-9 | 25g | $2500 | 2026-06-04 | Buy |
Acetyl Tetrapeptide-5 Chemical Properties, Uses, Production
Chemical Properties
Acetyl Tetrapeptide-5 is a white to cream coloured powder. The active ingredient is used to treat lachrymal sacs and dark circles under the eyes. It stimulates cell metabolism, improves skin elasticity, reduces puffiness and water retention in the eye area and makes the skin supple.
Characteristics
Acetyl tetrapeptide-5 inhibits collagen glycation avoiding skin losing elasticity and subsequent eyebags formation .
Acetyl tetrapeptide-5 prevents liquid accumulation in eyebags .
Acetyl tetrapeptide-5 shows a slight lightening effect which decreases dark circles under the eyes Use level: 0.01 %, maximum 0.1 % (water soluble)
Uses
Acetyl tetrapeptide-5 is known as eye peptide and eye silk peptide. The molecular weight of acetyltetrapeptide-5 is 492.5 and the amino acid sequence is Ac- βAla-His-Ser-His-OH, the molecular formula is C20H28N8O7. The influence of saccharification in the body and the increase of ocular vascular osmotic pressure will make the eye skin form dark circles and edema. Some studies have proved that acetyltetrapeptide-5 can reduce edema by changing the microcirculation of regional skin and the osmotic pressure of liquid, so as to effectively eliminate edema, eye bags and dark circles.
Definition
Acetyl Tetrapeptide-5 is a synthetic peptide that has calming, smoothing, hydrating, and firmness-enhancing benefits when applied to skin. Its calming properties are believed to reduce undereye puffiness due to fluid accumulation, such as from allergies (which is not the same as undereye bags that occur from fat pads beneath the skin slipping out of place).
Application
Acetyl tetrapeptisde-5 is a known humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity and overall smoothness.
benefits
Acetyl tetrapeptide-5 is an acetyl oligopeptide whose role is to inhibit collagen glycation and increase vascular permeability in a dose-dependent manner. This prevents liquid accumulation under the eyes and decreases eye puffiness, as well as improving skin elasticity. Two studies showed that acetyl tetrapeptide-5 reduced under-eye puffiness and discoloration.
Safety
Some humectants may be irritants at extremely high concentrations, but acetyl tetrapeptide-5 is generally considered non-hazardous to the body and the environment by the cosmetics database.
Acetyl Tetrapeptide-5 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4724 | 58 |
| Sichuan Jisheng Biopharmaceutical Co.,Ltd. | +86-0833-2598983 +86-18086877136 | Nyx-peptide@jsjpharm.cn | China | 287 | 58 |
| BJV(SHENZHEN) BIOTECH LTD | 19006605310 | 3794036058@qq.com | China | 96 | 58 |
| bociny | 18939812306 | sales@bociny.com | China | 207 | 58 |
| Hangzhou Jiedi Biotechnology Co., LTD | 0571-87325830 18142019433 | coonbio@163.com | China | 44 | 58 |
| Changsha Weixi Biotechnology Co., Ltd. | 17819579285 17819579285 | 552197795@qq.com | China | 31 | 58 |
| Alabiochem Tech.Co., Ltd. | 512-58900862 400-0707518 | sales@alabiochem.com | China | 988 | 59 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
Related articles
- Acetyl Tetrapeptide-5: Cosmeceutical Efficacy & Structural Modification Research
- Acetyl Tetrapeptide-5 is a synthetic pentapeptide compound with the sequence Ac-βAla-His-Ser-His.
- Mar 6,2026
- The important eye peptide of acetyl tetrapeptide-5
- Acetyl tetrapeptide-5 is known as eye peptide and eye silk peptide. The molecular weight of acetyltetrapeptide-5 is 492.5 and ....
- Apr 20,2022
View Latest Price from Acetyl Tetrapeptide-5 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Acetyl Tetrapeptide-5
820959-17-9
|
$30.00 | 15mg | 0.98 | 1kg | Shanghai UCHEM Inc. | |
 |
2026-09-16 | Acetyl Tetrapeptide-5
820959-17-9
|
1g | 98% | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-14 | Acetyl Tetrapeptide-5
820959-17-9
|
$500.00 | 1kg | ≥99.00% | 1000000 | Chengdu Shengnuo Biopharm Co.,Ltd |
-
- Acetyl Tetrapeptide-5
820959-17-9
- $30.00
- 0.98
- Shanghai UCHEM Inc.
-
- Acetyl Tetrapeptide-5
820959-17-9
- $0.00
- 98%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Acetyl Tetrapeptide-5
820959-17-9
- $500.00
- ≥99.00%
- Chengdu Shengnuo Biopharm Co.,Ltd
