Boc-Ser-OH
- CAS No.
- 59524-02-6
- Chemical Name:
- Boc-Ser-OH
- Synonyms
- Boc-L-Serine;N-BOC-L-SERINE;BOC-L-SER-OH;BOC-SER-OBZL;BOC-SERINE;BOC-L-SER;Boc-Ser-OH;BOC-SERINE-OH;BOC-L-SER-OBZL;BOC-SERINE-OBZL
- CBNumber:
- CB3668034
- Molecular Formula:
- C15H21NO5
- Molecular Weight:
- 295.33
- MDL Number:
- MFCD00076983
- MOL File:
- 59524-02-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 91 °C (dec.)(lit.) |
|---|---|
| Boiling point | 458.8±40.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 10.67±0.46(Predicted) |
| form | Powder |
| color | White |
| Water Solubility | Slightly soluble in water. |
| InChIKey | BQADRZHPZVQGCW-LBPRGKRZSA-N |
| CAS DataBase Reference | 59524-02-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HS Code | 2924297099 | |||||||||
| NFPA 704 |
|
Boc-Ser-OH price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265097 | Boc-L-serine benzyl ester Asreported | 59524-02-6 | 5g | $369 | 2026-06-03 | Buy |
| Usbiological | 265097 | Boc-L-serine benzyl ester Asreported | 59524-02-6 | 10g | $512 | 2026-06-03 | Buy |
| Usbiological | 265097 | Boc-L-serine benzyl ester Asreported | 59524-02-6 | 25g | $857 | 2026-06-03 | Buy |
| Usbiological | 265097 | Boc-L-serine benzyl ester Asreported | 59524-02-6 | 50g | $1207 | 2026-06-03 | Buy |
| Usbiological | 265097 | Boc-L-serine benzyl ester Asreported | 59524-02-6 | 100g | $1727 | 2026-06-03 | Buy |
Boc-Ser-OH Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
It is a pharmaceutical intermediate. It is involved in Mitsunobu Reactions.
Synthesis
3262-72-4
100-39-0
59524-02-6
GENERAL STEPS: To a stirred solution of N-Boc-L-serine (4.87 mmol) in DMF (100 mL) was added cesium carbonate (5.11 mmol) and stirring was continued for 30 minutes. Benzyl bromide (5.84 mmol) was then added and the reaction mixture was stirred for 12 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (25 mL) and washed sequentially with aqueous lithium bromide (3 × 15 mL), aqueous sodium bicarbonate (2 × 15 mL) and saturated saline (2 × 15 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent: petroleum ether/ether = 1:1) to afford Boc-L-serine benzyl ester (100% yield) as a white solid. rf = 0.26 (petroleum ether/ether = 1:1). To a stirred solution of N-Boc-L-serine (2.44 mmol) in DMF (50 mL) was added cesium carbonate (2.56 mmol) and stirring was continued for 30 min. Benzyl bromide (2.92 mmol) was then added and the reaction mixture was stirred for 12 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (15 mL) and washed sequentially with aqueous lithium bromide (3 × 10 mL), aqueous sodium bicarbonate (2 × 10 mL) and saturated saline (2 × 10 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent: petroleum ether/ether = 1:1) to give Boc-L-serine benzyl ester (100% yield) as a white solid. rf = 0.26 (petroleum ether/ether = 1:1).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 20, p. 3401 - 3404
[2] Patent: WO2005/41899, 2005, A2. Location in patent: Page/Page column 94; 102-103
[3] Journal of the American Chemical Society, 2012, vol. 134, # 45, p. 18809 - 18815
[4] Patent: US2017/158720, 2017, A1. Location in patent: Paragraph 0114; 0115; 0171; 0172
Boc-Ser-OH Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Boc-Ser-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | BOC-SER-OH
59524-02-6
|
$2.00 | 1kg | 99% | Career Henan Chemical Co |
-
- BOC-SER-OH
59524-02-6
- $2.00
- 99%
- Career Henan Chemical Co
