5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile
- CAS No.
- 103646-82-8
- Chemical Name:
- 5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile
- Synonyms
- BUTTPARK 51\09-61;5-Amino-1-(p-tolyl)pyrazole-4-carbonitrile;5-AMINO-4-CYANO-1-(4-METHYLPHENYL)PYRAZOLE;5-AMINO-1-P-TOLYL-1H-PYRAZOLE-4-CARBONITRILE;5-amino-1-toluene-1h-pyrazole-4-methylnitrile;5-Amino-1-(4-methylphenyl)pyrazole-4-carbonitrile;5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-methylphenyl)-;4-(5-Amino-4-cyano-1H-pyrazol-1-yl)toluene, 5-Amino-4-cyano-1-(4-methylphenyl)-1H-pyrazole
- CBNumber:
- CB3673067
- Molecular Formula:
- C11H10N4
- Molecular Weight:
- 198.22
- MDL Number:
- MFCD00052944
- MOL File:
- 103646-82-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 116-120 |
|---|---|
| Boiling point | 405.6±40.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -0.58±0.10(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| CAS DataBase Reference | 103646-82-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933199090 | |||||||||
| NFPA 704 |
|
5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A3039 | 5-Amino-1-(p-tolyl)pyrazole-4-carbonitrile | 103646-82-8 | 1G | $123 | 2026-04-30 | Buy |
| Biosynth | DEA64682 | 5-Amino-1-(p-tolyl)pyrazole-4-carbonitrile | 103646-82-8 | 5g | $295 | 2026-06-04 | Buy |
| Apolloscientific | OR14185 | 5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile ≥95% | 103646-82-8 | 1g | $41 | 2026-06-04 | Buy |
| Chem-Impex | 43608 | 5-Amino-1-(p-tolyl)pyrazole-4-carbonitrile ≥93%(GC) | 103646-82-8 | 1G | $192.19 | 2026-05-19 | Buy |
| Matrix Scientific | 043150 | 5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile | 103646-82-8 | 500.00mg | $118 | 2026-05-18 | Buy |
5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile Chemical Properties,Uses,Production
Synthesis
123-06-8
539-44-6
103646-82-8
GENERAL METHOD: p-Methylphenylhydrazine (0.001 mol) was mixed with 10 mL of ethanol, stirred and heated to reflux. Subsequently, ethoxymethylene malononitrile (0.001 mol) dissolved in 10 mL of ethanol was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. After completion of the reaction, the mixture was poured into 50 mL of ice water. The precipitated solid product was collected by filtration and washed with cold water to give the final 5-amino-1-toluene-1H-pyrazole-4-carbonitrile in 61-80% yield.
References
[1] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1876 - 1884
[2] Heterocyclic Communications, 2005, vol. 11, # 5, p. 385 - 388
[3] European Journal of Medicinal Chemistry, 2008, vol. 43, # 4, p. 771 - 780
[4] Journal of Organic Chemistry, 1956, vol. 21, p. 1240,1242
[5] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2121 - 2125
5-Amino-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3770 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
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