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4-Methylphenylhydrazine hydrochloride

4-Methylphenylhydrazine hydrochloride structure

CAS No.: 637-60-5

Chemical Name:: 4-Methylphenylhydrazine hydrochloride

Synonyms: P-TOLYLHYDRAZINE HYDROCHLORIDE;P-METHYLPHENYLHYDRAZINE HYDROCHLORIDE;Tolyl Hydrazine Hcl;4-TOLYLHYDRAZINE HCL;P-TOLYL HYDRAZINE HCL;PARA-TOLYLHYDRAZINEHCL;p-tolylhydrazine HCl salt;4-METHYLPHENYLHYDRAZINE HCL;p-tolyl-hydrazinhydrochloride;p-tolyhydrazine hydrochloride

CBNumber:: CB3178719

Molecular Formula:: C7H11ClN2

Molecular Weight:: 158.63

MDL Number:: MFCD00012940

MOL File:: 637-60-5.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
p-Tolylhydrazine hydrochloride 98%	T40606	25g	$155
p-Tolylhydrazine Hydrochloride >98.0%(T)	T0319	25g	$39
p-Tolylhydrazine Hydrochloride >98.0%(T)	T0319	250g	$197
4-TolylhydrazineMonohydrochloride	T536610	10g	$45
4-Methylphenylhydrazine hydrochloride 98%	3739-5-X4	100g	$192
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4-Methylphenylhydrazine hydrochloride Properties

Melting point	>200 °C (dec.)(lit.)
Boiling point	217.6°C (rough estimate)
Density	0.9532 (rough estimate)
refractive index	1.6230 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO, Methanol
form	Flaky Powder
color	Off-white to beige-brownish
Water Solubility	soluble
Merck	14,9542
BRN	3563996
CAS DataBase Reference	637-60-5(CAS DataBase Reference)
EPA Substance Registry System	Hydrazine, (4-methylphenyl)-, monohydrochloride (637-60-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08,GHS09

Signal word

Danger

Hazard statements

H301+H311+H331-H317-H350-H410

Precautionary statements

P201-P273-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-40

Safety Statements

26-36-36/37/39

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

MW0195000

Hazard Note

Harmful/Irritant

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29280090

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
2		1

4-Methylphenylhydrazine hydrochloride price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T40606	p-Tolylhydrazine hydrochloride 98%	637-60-5	25g	$155	2025-07-31	Buy
TCI Chemical	T0319	p-Tolylhydrazine Hydrochloride >98.0%(T)	637-60-5	25g	$39	2025-07-31	Buy
TCI Chemical	T0319	p-Tolylhydrazine Hydrochloride >98.0%(T)	637-60-5	250g	$197	2021-12-16	Buy
TRC	T536610	4-TolylhydrazineMonohydrochloride	637-60-5	10g	$45	2021-12-16	Buy
SynQuest Laboratories	3739-5-X4	4-Methylphenylhydrazine hydrochloride 98%	637-60-5	100g	$192	2021-12-16	Buy

Product number	Packaging	Price	Buy
T40606	25g	$155	Buy
T0319	25g	$39	Buy
T0319	250g	$197	Buy
T536610	10g	$45	Buy
3739-5-X4	100g	$192	Buy

4-Methylphenylhydrazine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

off-white to beige-brownish flaky powder

Uses

4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.

Synthesis

106-49-0

637-60-5

General procedure for the synthesis of 4-methylphenylhydrazine hydrochloride from 4-methylaniline: 4-methylaniline (10.7 g, 0.1 mol) was mixed with dilute hydrochloric acid in a 200 ml round bottom flask. Sodium nitrite solution (30 ml, 7.3 g, 0.105 mol) was added slowly and dropwise to the above mixture. The reaction mixture was stirred for 1 hour and then filtered. The filtered clear liquid was added dropwise to 70 ml of aqueous solution containing sodium sulfite (37.8 g, 0.3 mol) and reacted at 80°C for about 1.5 hours. Subsequently, concentrated hydrochloric acid (25 ml, 0.3 mol) was added slowly and the reaction temperature was raised to 95°C and the reaction continued for about 2.5 hours. Upon completion of the reaction, the mixture was allowed to stand at room temperature overnight to precipitate 4-methylphenylhydrazine hydrochloride as a solid. After filtration and drying, 12.9 g of product was obtained in 90.0% yield.

References

[1] Patent: CN108623511, 2018, A. Location in patent: Paragraph 0021
[2] Patent: EP2157088, 2010, A1. Location in patent: Page/Page column 41-42
[3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1706 - 1712

4-Methylphenylhydrazine hydrochloride synthesis

Synthesis of 4-Methylphenylhydrazine hydrochloride from Methanone, diphenyl-, 2-(4-methylphenyl)hydrazone

4-Methylphenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

p-Toluidine 4-Bromotoluene Sodium sulfite Hydrochloric acid Sodium nitrite

Preparation Products

5-METHYLTRYPTAMINE HYDROCHLORIDE 5-Methyl-L-tryptophan 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBONITRILE P-TOLYL DISULFIDE BENZYL 5-METHYLSPIRO[INDOLINE-3,4'-PIPERIDINE]-1'-CARBOXYLATE

1-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one 7-Methyl-1,4-dihydro-2H-cyclopenta[b]indol-3-one

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4-Methylphenylhydrazine hydrochloride Suppliers

Global( 385)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12246	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8826	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 4-Methylphenylhydrazine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	4-Methylphenylhydrazine hydrochloride 637-60-5	US $50.00-20.00 / kg	1kg	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	4-Methylphenylhydrazine hydrochloride 637-60-5	US $10.00-0.80 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-09-11	4-Methylphenylhydrazine hydrochloride 637-60-5	US $0.00 / KG	1KG	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.

4-Methylphenylhydrazine hydrochloride
637-60-5
US $50.00-20.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Methylphenylhydrazine hydrochloride
637-60-5
US $10.00-0.80 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Methylphenylhydrazine hydrochloride
637-60-5
US $0.00 / KG
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

4-Methylphenylhydrazine hydrochloride Spectrum

4-Methylphenylhydrazine hydrochloride(637-60-5)MS 4-Methylphenylhydrazine hydrochloride(637-60-5)¹HNMR 4-Methylphenylhydrazine hydrochloride(637-60-5)¹³CNMR 4-Methylphenylhydrazine hydrochloride(637-60-5)IR1 4-Methylphenylhydrazine hydrochloride(637-60-5)IR2 4-Methylphenylhydrazine hydrochloride(637-60-5)Raman

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