4-(1H-Benzoimidazol-2-yl)-phenylamine
- CAS No.
- 2963-77-1
- Chemical Name:
- 4-(1H-Benzoimidazol-2-yl)-phenylamine
- Synonyms
- AKOS BB-7980;ASISCHEM T31097;imidazol-CHEMBRDG-BB 4101671;TIMTEC-BB SBB000485;4-(2-Benzimidazolyl)aniline;4-(1H-Benzo[d]imidazol-2-yl);2-[p-Aminophenyl]benzimidazole;2-(p-Aminophenyl)benzimidazole;2-(4-Aminophenyl)benzimidazole
- CBNumber:
- CB3685387
- Molecular Formula:
- C13H11N3
- Molecular Weight:
- 209.25
- MDL Number:
- MFCD00454395
- MOL File:
- 2963-77-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 248.0 to 252.0 °C |
|---|---|
| Boiling point | 466.3±47.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 11.77±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| λmax | 314nm(HCl aq.)(lit.) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H318-H361-H317-H351-H335-H410 | |||||||||
| Precautionary statements | P501-P273-P272-P260-P202-P201-P271-P280-P284-P302+P352-P391-P308+P313-P362+P364-P333+P313-P304+P340+P310-P305+P351+P338+P310-P403+P233-P405 | |||||||||
| Hazard Codes | Xi | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
4-(1H-Benzoimidazol-2-yl)-phenylamine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R702587 | 4-(1H-BENZIMIDAZOL-2-YL)ANILINE AldrichCPR | 2963-77-1 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | R702587 | 4-(1H-BENZIMIDAZOL-2-YL)ANILINE AldrichCPR | 2963-77-1 | 25MG | $179 | 2024-03-01 | Buy |
| TCI Chemical | B5710 | 4-(1H-Benzimidazol-2-yl)aniline >98.0%(HPLC)(T) | 2963-77-1 | 1g | $144 | 2026-04-30 | Buy |
| TCI Chemical | B5710 | 4-(1H-Benzimidazol-2-yl)aniline >98.0%(HPLC)(T) | 2963-77-1 | 5g | $502 | 2026-04-30 | Buy |
| Chem-Impex | 42617 | 4-(1H-Benzimidazol-2-yl)aniline ≥98%(HPLC) | 2963-77-1 | 1G | $215.92 | 2026-05-19 | Buy |
4-(1H-Benzoimidazol-2-yl)-phenylamine Chemical Properties, Uses, Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 39, p. 3375, 1996 DOI: 10.1021/jm9600959
Synthesis
150-13-0
95-54-5
2963-77-1
The reaction was carried out with 4-aminobenzoic acid (5 g, 5.78 mmol) and o-phenylenediamine (3.9 g, 3.68 mmol) in polyphosphoric acid (12.5 g) with stirring at 200 °C for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into crushed ice. Subsequently, the precipitate was stirred in cold water. The pH was adjusted with ammonium hydroxide solution to 7. The solid product was collected by filtration and washed several times with methanol. Finally, the target compound 4-(1H-benzimidazol-2-yl)aniline (5) was purified as a white solid by silica gel column chromatography using ethyl acetate: hexane (4:1) as eluent. Yield: 82%; Melting point: 207-209 °C; 1H NMR (400 MHz, DMSO-d6): δ= 7.96 (d, 2H, J = 8.72 Hz, ArH), 7.55-7.51 (m, 2H, ArH), 7.16-7.14 (m, 2H, ArH), 6.75 (d, 2H, J = 8.24 Hz, ArH) , 4.45 (bs, 2H, NH2); 13C NMR (100 MHz, DMSO-d6): δ= 152.2,148.4,127.5,120.9,118.6,113.8 (ArC); MS (ESI), m/z: 210.2 (M++1).
References
[1] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 1, p. 115 - 117
[2] Chinese Chemical Letters, 2011, vol. 22, # 3, p. 296 - 299
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 24 - 35
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 59 - 69
[5] Journal of the Chilean Chemical Society, 2012, vol. 57, # 2, p. 1122 - 1125,4
4-(1H-Benzoimidazol-2-yl)-phenylamine Preparation Products And Raw materials
4-(1H-Benzoimidazol-2-yl)-phenylamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2270 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
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