Spectinomycin dihydrochloride
- CAS No.
- 21736-83-4
- Chemical Name:
- Spectinomycin dihydrochloride
- Synonyms
- SPECTINOMYCIN HYDROCHLORIDE;Gentamicin hydrochloride;M 141;stanilo;U-18409AE;NSC 248616;Spectacomycin;SPECTINOMYCIN 2HCL;SPECTINOMYCIN DIHYDROC;Spectinomycin (50mg/ml)
- CBNumber:
- CB3690961
- Molecular Formula:
- C14H24N2O7.2ClH
- Molecular Weight:
- 405.27
- MDL Number:
- MFCD00070403
- MOL File:
- 21736-83-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 194°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, faintly yellow |
| form | powder |
| color | White to Off-White |
| InChIKey | BIPVCOUVVAMJMZ-CEDDKZKHNA-N |
| SMILES | N([C@H]1[C@H]([C@@H](NC)[C@H](O)[C@@]2([H])O[C@]3([H])O[C@H](C)CC(=O)[C@]3(O)O[C@]12[H])O)C.Cl |&1:1,2,3,6,8,11,14,19,22,r| |
| FDA UNII | 296JEI210Z |
| UNSPSC Code | 12352207 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334-H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501 |
| WGK Germany | 2 |
| RTECS | WG7400000 |
| F | 10 |
| Storage Class | 10 - Combustible liquids |
| Toxicity | monkey,LD50,oral,500mg/kg (500mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965. |
Spectinomycin dihydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 021013 | Spectinomycin Dihydrochloride ~90% | 21736-83-4 | 1g | $347 | 2026-06-03 | Buy |
| Usbiological | 021013 | Spectinomycin Dihydrochloride ~90% | 21736-83-4 | 10g | $538 | 2026-06-03 | Buy |
| ChemScene | CS-2544 | Spectinomycin dihydrochloride 99.73% | 21736-83-4 | 500mg | $60 | 2026-06-04 | Buy |
| ChemScene | CS-2544 | Spectinomycin dihydrochloride 99.73% | 21736-83-4 | 1g | $71 | 2026-06-04 | Buy |
| ChemScene | CS-2544 | Spectinomycin dihydrochloride 99.73% | 21736-83-4 | 5g | $107 | 2026-06-04 | Buy |
Spectinomycin dihydrochloride Chemical Properties, Uses, Production
Chemical Properties
SPECTINOMYCIN DIHYDROCHLORIDE is White Powder
Uses
SPECTINOMYCIN DIHYDROCHLORIDE is an antibiotic used in the treatment and control of infectious bacterial enteritis in animals. Used in drug testing against nonreplicating mycobacterium tuberculosis.
Uses
Antibacterial;Ribosomal protein
Definition
SPECTINOMYCIN DIHYDROCHLORIDE is a hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.
Application
In clinical veterinary treatment of livestock and poultry, Spectinomycin dihydrochloride is mainly used to treat diseases caused by sensitive bacterial infections such as Escherichia coli, Salmonella, Pasteurella and Mycoplasma.
Clinical Use
The aminocyclitol antibiotic spectinomycin hydrochloride(Trobicin), isolated from Streptomyces spectabilis andonce called actinospectocin, was first described by Lewisand Clapp. Its structure and absolute stereochemistryhave been confirmed by x-ray crystallography. It occursas the white, crystalline dihydrochloride pentahydrate,which is stable in the dry form and very soluble in water.Solutions of spectinomycin, a hemiacetal, slowly hydrolyzeon standing and should be prepared freshly andused within 24 hours. It is administered by deep intramuscularinjection.
Spectinomycin is a broad-spectrum antibiotic withmoderate activity against many Gram-positive and Gramnegativebacteria. It differs from streptomycin and thestreptamine-containing aminoglycosides in chemical and antibacterialproperties. Like streptomycin, spectinomycininterferes with the binding of transfer RNA (tRNA) to the ribosomesand thus with the initiation of protein synthesis.Unlike streptomycin or the streptamine-containing antibiotics,however, it does not cause misreading of the messenger.Spectinomycin exerts a bacteriostatic action and isinferior to other aminoglycosides for most systemic infections.Currently, it is recommended as an alternative to penicillinG salts for the treatment of uncomplicated gonorrhea.A cure rate of more than 90% has been observed in clinicalstudies for this indication. Many physicians prefer to use atetracycline or erythromycin for prevention or treatment ofsuspected gonorrhea in penicillin-sensitive patients because,unlike these agents, spectinomycin is ineffective againstsyphilis. Furthermore, it is considerably more expensive thanerythromycin and most of the tetracyclines.
Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx and HCl.
Purification Methods
The salt is purified by recrystallisation from aqueous Me2CO and is soluble in H2O, MeOH and dilute acid and base, but only slightly soluble in Me2CO, EtOH, CHCl3 and *C6H6. The free base is an amorphous solid, m 184-194o with []D -20o (H2O). [Wiley et al. J Am Chem Soc 93 2652 1963, X-ray: Cochran et al. J Chem Soc Chem Commun 494 1972.] It is an aminoglycoside antibiotic which interacts with 16S ribosomal RNA [Moazet & Noller Nature 327 389 1987] and is used for the treatment of gonorrhea [Rinehart J Infect Dis 119 345 1969].
Spectinomycin dihydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2689 | 58 |
View Latest Price from Spectinomycin dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-01 | Spectinomycin Hydrochloride
21736-83-4
|
1kg | 99% | 5000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2026-09-01 | Spectinomycin Hydrochloride
21736-83-4
|
1kg | 99% | 20tons | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2026-08-20 | Spectinomycin dihydrochloride
21736-83-4
|
$42.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- Spectinomycin Hydrochloride
21736-83-4
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Spectinomycin Hydrochloride
21736-83-4
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Spectinomycin dihydrochloride
21736-83-4
- $42.00
- 99.90%
- TargetMol Chemicals Inc.
