Ascomycin
- CAS No.
- 11011-38-4
- Chemical Name:
- Ascomycin
- Synonyms
- Ascomycin (FK520);AAG;anpg;APNG;PIG16;FK-520;CS-740;CGTHBA;CRA36.1;FR-900520
- CBNumber:
- CB5406331
- Molecular Formula:
- C43H69NO12
- Molecular Weight:
- 792.01
- MDL Number:
- MFCD06198665
- MOL File:
- 11011-38-4.mol
- MSDS File:
- SDS
| Melting point | 158 - 161°C |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming). |
| form | White crystalline solid |
| color | White |
| biological source | goat |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351-H413-H361-H302 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | WGK 2 |
| RTECS | CI7570000 |
| Storage Class | 10 - Combustible liquids |
Ascomycin price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB2501813 | Anti-Nprl3 antibody produced in goat affinity isolated antibody, buffered aqueous solution | 11011-38-4 | 100μG | $628 | 2026-04-30 | Buy |
| Sigma-Aldrich | 182800 | Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem An ethyl analog of FK506 with similar immunosuppressant properties. | 11011-38-4 | 1mg | $205 | 2022-05-15 | Buy |
| Usbiological | 441818 | Ascomycin||NEED TO REMOVE ; SAME AS A781000 | 11011-38-4 | 1mg | $305 | 2026-06-03 | Buy |
| Usbiological | 441818 | Ascomycin||NEED TO REMOVE ; SAME AS A781000 | 11011-38-4 | 2.5mg | $432 | 2026-06-03 | Buy |
| aablocks | AA003AKQ | 17-Ethyl-1,14-dihydroxy-12-[2′-(4′′-hydroxy-3′′-methoxycyclohexyl)-1′-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone 99% | 11011-38-4 | 10mg | $200 | 2026-05-28 | Buy |
Ascomycin Chemical Properties, Uses, Production
Description
Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from biological fermentation.
Uses
A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.
General Description
An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
Biochem/physiol Actions
Product does not compete with ATP.
Enzyme inhibitor
This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.
Background
Ascomycin is a 23-membered macrolide lactone produced from the fermentation of Streptomyces hygroscopicus. A natural analogue of FK506, Ascomycin has the ability to bind to FK506-binding protein 12, inhibiting calcineurin phosphatase activity, and disrupting the activation of nuclear factor of activated T cells and other various substrates. Primarily described as an antifungal antibiotic, Ascomycin has shown to be a potent immunosuppressant used to prevent the rejection of organ transplants and skin allografts. Ascomycin displays powerful antimalarial properties independent of its immunosuppressive mechanisms of action.
References
[1] H HATANAKA. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.[J]. Journal of Antibiotics, 1988, 41 11: 1592-1601. DOI:10.7164/antibiotics.41.1592
[2] A. M. PETROS. NMR studies of an FK-506 analog [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding[J]. Journal of Medicinal Chemistry, 1991, 34 9: 2925-2928. DOI:10.1021/jm00113a037
[3] KARL W. MOLLISON. A Macrolactam Inhibitor of T Helper Type 1 and T Helper Type 2 Cytokine Biosynthesis for Topical Treatment of Inflammatory Skin Diseases1[J]. Journal of Investigative Dermatology, 1999, 112 5: Pages 729-738. DOI:10.1046/j.1523-1747.1999.00567.x
Ascomycin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huzhou fuhe Rui biological medicine co., ltd | 13626726938;18067822612 | China | 791 | 58 | |
| Shanghai Jiapu Biotechnology Co., Ltd | 18221901645 | 18221901645@163.com | China | 68 | 58 |
| NanJing Vtrying Pharmatech Co.,Ltd | 173 1418 6806; 17314186806 | Vtrying_sale@163.com | China | 303 | 58 |
| Wuhan SynBioLily Biotechnology Co.,Ltd. | 18971458902 | yangsong@synbiolily.com | China | 482 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
View Latest Price from Ascomycin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | Ascomycin
11011-38-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-15 | Ascomycin
11011-38-4
|
1KG | 99% | 10 KG | Jinan Hong Kongda Chemical Co.,LTD | ||
 |
2026-08-20 | Ascomycin
11011-38-4
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
