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2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid

2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid structure

CAS No.: 668484-45-5

Chemical Name:: 2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid

Synonyms: 2-(PIPERDIN-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, N1-BOC PROTECTED;2-[1-(tert-butoxycarbonyl)piperid-4-yl]-1,3-thiazole-4-carboxylic acid;2-[1-(TERT-BUTOXYCARBONYL)PIPERDIN-4-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid;2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid;1-Piperazinecarboxylic acid, 4-(4-carboxy-2-thiazolyl)-, 1-(1,1-dimethylethyl) ester;1-(tert-Butoxycarbonyl)-4-(4-carboxy-1,3-thiazol-2-yl)piperidine, 2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-carboxy-1,3-thiazole

CBNumber:: CB3698558

Molecular Formula:: C13H19N3O4S

Molecular Weight:: 313.37

MDL Number:: MFCD06658980

MOL File:: 668484-45-5.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:10

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2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid Properties

Melting point	162 °C
Boiling point	0°C
Density	1.332±0.06 g/cm3(Predicted)
Flash point	0°C
storage temp.	2-8°C
pka	1.35±0.10(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Risk Statements

36/37/38

Safety Statements

26-36

HazardClass

IRRITANT

HS Code

2934100090

NFPA 704

	1
2		0

2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	TBB48445	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid	668484-45-5	2.5g	$472	2026-06-05	Buy
Apolloscientific	OR0511	2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid 98%	668484-45-5	100mg	$36	2026-06-04	Buy
Apolloscientific	OR0511	2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid 98%	668484-45-5	250mg	$75	2026-06-04	Buy
Apolloscientific	OR0511	2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid 98%	668484-45-5	1g	$210	2026-06-04	Buy
Synthonix	B57147	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid 98%	668484-45-5	100mg	$63	2026-05-06	Buy

Product number	Packaging	Price	Buy
TBB48445	2.5g	$472	Buy
OR0511	100mg	$36	Buy
OR0511	250mg	$75	Buy
OR0511	1g	$210	Buy
B57147	100mg	$63	Buy

2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid Chemical Properties, Uses, Production

Synthesis

Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate

867065-53-0

668484-45-5

General procedure for the synthesis of 2-[1-(tert-butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid from ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate: ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid (2.0 g) was dissolved in ethanol (10 mL) and tetrahydrofuran (10 mL) as a mixed solvents and 2 N aqueous sodium hydroxide solution (5 mL) was added. The reaction mixture was stirred at 60 °C for 2 hours. After completion of the reaction, the pH was adjusted to 1 with 1 N hydrochloric acid and a precipitate was precipitated, which was collected by filtration and dried to give a light-colored solid product (1.7 g, 94% yield).

References

[1] Patent: US2018/141923, 2018, A1. Location in patent: Paragraph 0599; 0602; 0603

2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Tetrahydrofuran Sodium hydroxide Ethanol

Preparation Products

2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid Suppliers

Global Suppliers ( 48)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9336	55
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	22497	55
SynAsst Chemical.	021-60343070		China	12731	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Shanghai Civic Chemical Technology Co., Ltd.	021-34053660	sale2@labgogo.com	China	2018	58
Amatek Scientific Co. Ltd.	0512-56316828 400-867-5858;400-867-5858	info@amateksci.com	China	28760	58
Aikon International Limited	025-58851090 13913916777	sales01@aikonchem.com	China	15947	58

Supplier	Advantage
Wuhan Chemwish Technology Co., Ltd	56
Thermo Fisher Scientific	75
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
9ding chemical ( Shanghai) Limited	55
SynAsst Chemical.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Amadis Chemical Company Limited	58
Shanghai Civic Chemical Technology Co., Ltd.	58
Amatek Scientific Co. Ltd.	58
Aikon International Limited	58

2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid Spectrum

2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID(668484-45-5)¹HNMR

668484-45-5 (2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid) Related Search:

2-Propyl-1,3-thiazole-4-carboxylic acid tert-Butyl 4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate 2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate 4-Formyl-2-isopropylthiazole

4-Thiazolecarboxylicacid,2-(1-methylethyl)-(9CI) tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate

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2-(PIPERDIN-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, N1-BOC PROTECTED 2-[1-(TERT-BUTOXYCARBONYL)PIPERDIN-4-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-[1-(tert-butoxycarbonyl)piperid-4-yl]-1,3-thiazole-4-carboxylic acid 2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid 1-(tert-Butoxycarbonyl)-4-(4-carboxy-1,3-thiazol-2-yl)piperidine, 2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-carboxy-1,3-thiazole 1-Piperazinecarboxylic acid, 4-(4-carboxy-2-thiazolyl)-, 1-(1,1-dimethylethyl) ester 2-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid 668484-45-5