|
|
| | 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Basic information |
| Product Name: | 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID | | Synonyms: | 2-(PIPERDIN-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID, N1-BOC PROTECTED;2-[1-(TERT-BUTOXYCARBONYL)PIPERDIN-4-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[1-(tert-butoxycarbonyl)piperid-4-yl]-1,3-thiazole-4-carboxylic acid;2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxylic acid;1-(tert-Butoxycarbonyl)-4-(4-carboxy-1,3-thiazol-2-yl)piperidine, 2-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-carboxy-1,3-thiazole;1-Piperazinecarboxylic acid, 4-(4-carboxy-2-thiazolyl)-, 1-(1,1-dimethylethyl) ester | | CAS: | 668484-45-5 | | MF: | C13H19N3O4S | | MW: | 313.37 | | EINECS: | | | Product Categories: | | | Mol File: | 668484-45-5.mol | ![2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Structure](CAS/GIF/668484-45-5.gif) |
| | 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties |
| Melting point | 162 °C | | Boiling point | 0°C | | density | 1.332±0.06 g/cm3(Predicted) | | Fp | 0°C | | storage temp. | 2-8°C | | pka | 1.35±0.10(Predicted) | | Appearance | White to off-white Solid |
| Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | HazardClass | IRRITANT | | HS Code | 2934100090 |
| | 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-[1-(tert-butoxycarbonyl)-4-piperidinyl]-1,3-thiazole-4-carboxylic acid from ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate: ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid (2.0 g) was dissolved in ethanol (10 mL) and tetrahydrofuran (10 mL) as a mixed solvents and 2 N aqueous sodium hydroxide solution (5 mL) was added. The reaction mixture was stirred at 60 °C for 2 hours. After completion of the reaction, the pH was adjusted to 1 with 1 N hydrochloric acid and a precipitate was precipitated, which was collected by filtration and dried to give a light-colored solid product (1.7 g, 94% yield). | | References | [1] Patent: US2018/141923, 2018, A1. Location in patent: Paragraph 0599; 0602; 0603 |
| | 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials |
|