TOFISOPAM
- CAS No.
- 22345-47-7
- Chemical Name:
- TOFISOPAM
- Synonyms
- SERIEL;Tosopam;EGYT 341;TOFISOPAM;tofizopam;grandaxin;Tofisopam, >=99%;TOFISOPAM 22345-47-7;Tofisopam, 10 mM in DMSO;7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE
- CBNumber:
- CB3738807
- Molecular Formula:
- C22H26N2O4
- Molecular Weight:
- 382.45
- MDL Number:
- MFCD00823171
- MOL File:
- 22345-47-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155-159°C |
|---|---|
| Boiling point | 509.61°C (rough estimate) |
| Density | 1.2098 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| solubility | DMSO: ~14 mg/mL |
| pka | 7.29±0.40(Predicted) |
| form | solid |
| color | white |
| λmax | 310nm(MeOH)(lit.) |
| Merck | 14,9503 |
| Stability | Hygroscopic |
| InChI | 1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3 |
| InChIKey | RUJBDQSFYCKFAA-UHFFFAOYSA-N |
| SMILES | CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13 |
| FDA UNII | UZC80HAU42 |
| ATC code | N05BA23 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DE9540000 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 |
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| NFPA 704 |
|
TOFISOPAM price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T8200 | Tofisopam ≥98% (HPLC), solid | 22345-47-7 | 10mg | $194 | 2026-04-30 | Buy |
| Sigma-Aldrich | T8200 | Tofisopam ≥98% (HPLC), solid | 22345-47-7 | 50mg | $615 | 2026-04-30 | Buy |
| TCI Chemical | T3509 | Tofisopam >98.0%(HPLC) | 22345-47-7 | 50mg | $53 | 2026-04-30 | Buy |
| TCI Chemical | T3509 | Tofisopam >98.0%(HPLC) | 22345-47-7 | 250mg | $176 | 2026-04-30 | Buy |
| Cayman Chemical | 22026 | Tofisopam ≥95% | 22345-47-7 | 1mg | $81 | 2026-04-30 | Buy |
TOFISOPAM Chemical Properties, Uses, Production
Originator
Grandaxine,Ozothine,France,1975
Uses
Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant.
Definition
ChEBI: Tofisopam is an organic molecular entity.
Manufacturing Process
A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)- benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 136°C (after recrystallizing from absolute ethanol, 136°C)
Therapeutic Function
Tranquilizer
Biological Activity
Studies have reported th at tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.', 'Ligand for the GABAA receptor benzodiazepine modulatory site.
TOFISOPAM Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Hangzhou Maicke Pharmaceutical Technology Co., Ltd. | 189-05714267 | maicke@maicke.com | China | 16 | 60 |
| China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 762 | 50 | |
| Wuxi Zhangkun Biochemical Technology Co., Ltd. | +86 0510-85629785 | China | 2321 | 58 |
View Latest Price from TOFISOPAM manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | TOFISOPAM
22345-47-7
|
$10.00 | 1g | 99 | 100kg/kg | Shijiazhuang tongyang Import and Export Co., LTD | |
 |
2019-07-31 | TOFISOPAM 22345-47-7
22345-47-7
|
$1.00 | 1g | 99% | Cangzhou Wanyou New Material Technology Co.,Ltd | ||
 |
2019-07-06 | TOFISOPAM
22345-47-7
|
$14.00 | 1KG | 98% | 50KG | Career Henan Chemical Co |
-
- TOFISOPAM
22345-47-7
- $10.00
- 99
- Shijiazhuang tongyang Import and Export Co., LTD
-
- TOFISOPAM 22345-47-7
22345-47-7
- $1.00
- 99%
- Cangzhou Wanyou New Material Technology Co.,Ltd
-
- TOFISOPAM
22345-47-7
- $14.00
- 98%
- Career Henan Chemical Co
