2-Methoxy-5-methylphenylboronic acid
- CAS No.
- 127972-00-3
- Chemical Name:
- 2-Methoxy-5-methylphenylboronic acid
- Synonyms
- AKOS BRN-0586;CHEMBRDG-BB 4008663;2-Methoxy-5-Methylphenylboroni;2-Methoxy-5-methylphenylboronic Aci;5-Methyl-2-methoxyphenylboronic acid;2-METHOXY-5-METHYLPHENYLBORONIC ACID;(2-Methoxy-5-methylphenyl)boranediol;5-METHOXY-2-METHYLPHENYL BORONIC ACID;(2-METHOXY-5-METHYLBENZENE)BORONIC ACID;2-Methoxy-5-methylphenylboronic acid >=95%
- CBNumber:
- CB3742237
- Molecular Formula:
- C8H11BO3
- Molecular Weight:
- 165.98
- MDL Number:
- MFCD02179465
- MOL File:
- 127972-00-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 92-97 °C (lit.) |
|---|---|
| Boiling point | 342.0±52.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in methanol. |
| form | powder to crystal |
| pka | 8.65±0.58(Predicted) |
| color | White to Almost white |
| InChI | 1S/C8H11BO3/c1-6-3-4-8(12-2)7(5-6)9(10)11/h3-5,10-11H,1-2H3 |
| InChIKey | CSVKZOZMPSRLTC-UHFFFAOYSA-N |
| SMILES | COc1ccc(C)cc1B(O)O |
| CAS DataBase Reference | 127972-00-3(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-60-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
2-Methoxy-5-methylphenylboronic acid price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 567507 | 2-Methoxy-5-methylphenylboronic acid ≥95% | 127972-00-3 | 1g | $127 | 2023-06-20 | Buy |
| Sigma-Aldrich | 567507 | 2-Methoxy-5-methylphenylboronic acid ≥95% | 127972-00-3 | 5g | $290 | 2023-06-20 | Buy |
| TCI Chemical | M2311 | 2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride) | 127972-00-3 | 5g | $349 | 2026-04-30 | Buy |
| TCI Chemical | M2311 | 2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride) | 127972-00-3 | 25g | $1257 | 2026-04-30 | Buy |
| Apolloscientific | OR10526 | (2-Methoxy-5-methylbenzene)boronic acid >98% | 127972-00-3 | 5g | $21 | 2026-06-04 | Buy |
2-Methoxy-5-methylphenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
Reactant for:
- Coupling reactions
- Preparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants
- Rh-catalyzed asymmetric arylation of aldehydes
- Stereoselective hydroarylation reactions
- Suzuki-Miyaura cross-coupling
Uses
suzuki reaction
Synthesis
121-43-7
22002-45-5
127972-00-3
To a solution of 2-bromo-1-methoxy-4-methylbenzene (1.39 g, 15 mmol) in tetrahydrofuran (THF) was slowly added n-butyllithium (15 mmol) dropwise under nitrogen protection and -78 °C. The solution was stirred for 1 h. The solution was then mixed with tetramethyl borate (100 mL). After maintaining -78 °C and stirring for 1 h, the solution was transferred to a solution of THF (100 mL) containing trimethyl borate (15 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Subsequently, the reaction mixture was poured into 3N hydrochloric acid (125 mL) and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellowish white solid product 2-methoxy-5-methylphenylboronic acid (2.2 g, 89% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 7.6 (s, 1H), 7.38 (d, J = 2.3 Hz, 1H), 7.19 (dd, J = 8.4 Hz, 2.3 Hz, 1H), 6.87 (d, J = 8.4 Hz, 1H), 3.78 (s, 3H), 2.2 (s, 3H).
References
[1] Patent: US2004/19190, 2004, A1. Location in patent: Page 24
[2] Patent: US5688808, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5688810, 1997, A
[5] Patent: US5693647, 1997, A
2-Methoxy-5-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
View Lastest Price from 2-Methoxy-5-methylphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 2-Methoxy-5-methylphenylboronic acid
127972-00-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2-Methoxy-5-methylphenylboronic acid
127972-00-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 2-Methoxy-5-methylphenylboronic acid
127972-00-3
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-Methoxy-5-methylphenylboronic acid
127972-00-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Methoxy-5-methylphenylboronic acid
127972-00-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Methoxy-5-methylphenylboronic acid
127972-00-3
- $2.00
- 99%
- Career Henan Chemical Co
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