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ChemicalBook >> CAS DataBase List >>2,3,5,6-Tetrafluoroaniline

2,3,5,6-Tetrafluoroaniline

2,3,5,6-Tetrafluoroaniline Structure
2,3,5,6-Tetrafluoroaniline structure
CAS No.
700-17-4
Chemical Name:
2,3,5,6-Tetrafluoroaniline
Synonyms
2,3,5,6-TETRAFLUOROBENZENAMINE;Tetrafluoroaniline3;Tetrafluorobenzenamine;2,3,5,6-Tetrafluoraniline;2,3,5,6-TETRAFLUOROANILINE;Aniline, 2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoroaniline98%;2,3,5,6-Tetrafluoroaniline 98%;Benzenamine, 2,3,5,6-tetrafluoro-;1-Amino-2,3,5,6-tetrafluorobenzene
CBNumber:
CB3774775
Molecular Formula:
C6H3F4N
Molecular Weight:
165.09
MDL Number:
MFCD00007644
MOL File:
700-17-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:56:41
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2,3,5,6-Tetrafluoroaniline Properties

Melting point 31-32 °C(lit.)
Boiling point 158 °C(lit.)
Density 1,744 g/cm3
Flash point 145 °F
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility perchloric acid: soluble
pka -0.22±0.10(Predicted)
form powder to lump to clear liquid
color White or Colorless to Light orange to Yellow
BRN 2211579
InChI InChI=1S/C6H3F4N/c7-2-1-3(8)5(10)6(11)4(2)9/h1H,11H2
InChIKey SPSWJTZNOXMMMV-UHFFFAOYSA-N
SMILES C1(N)=C(F)C(F)=CC(F)=C1F
CAS DataBase Reference 700-17-4(CAS DataBase Reference)
FDA UNII L6G8W27VFU
NIST Chemistry Reference 2,3,5,6-Tetrafluoroaniline(700-17-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS07,GHS06
Signal word  Warning
Hazard statements  H315-H319-H335-H302-H312-H331
Precautionary statements  P280-P304+P340-P405-P501a-P261-P305+P351+P338
Hazard Codes  Xi,T,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36/37/39-36
RIDADR  2941
WGK Germany  3
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29214200
NFPA 704
2
2 0

2,3,5,6-Tetrafluoroaniline price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T1028 2,3,5,6-Tetrafluoroaniline >97.0%(GC) 700-17-4 5g $48 2026-04-30 Buy
TCI Chemical T1028 2,3,5,6-Tetrafluoroaniline >97.0%(GC) 700-17-4 25g $145 2026-04-30 Buy
Usbiological 289666 2,3,5,6-Tetrafluoroaniline Asreported 700-17-4 5g $333 2026-06-03 Buy
Usbiological 289666 2,3,5,6-Tetrafluoroaniline Asreported 700-17-4 10g $453 2026-06-03 Buy
Usbiological 289666 2,3,5,6-Tetrafluoroaniline Asreported 700-17-4 25g $638 2026-06-03 Buy
Product number Packaging Price Buy
T1028 5g $48 Buy
T1028 25g $145 Buy
289666 5g $333 Buy
289666 10g $453 Buy
289666 25g $638 Buy

2,3,5,6-Tetrafluoroaniline Chemical Properties, Uses, Production

Uses

2,3,5,6-Tetrafluoroaniline is a white solid and an important pharmaceutical and pesticide intermediate. It can be used as a raw material to synthesize a variety of drugs that are effective in treating inflammation and depression, and has good pharmaceutical effects.

Chemical Properties

WHITE CRYSTALLINE MASS

Synthesis

4-AMINO-2,3,5,6-TETRAFLUOROBENZONITRILE

17823-38-0

2,3,5,6-Tetrafluoroaniline

700-17-4

The general procedure for the synthesis of 2,3,5,6-tetrafluoroaniline from 4-amino-2,3,5,6-tetrafluorobenzonitrile was as follows: 867.6 grams of sulfuric acid with a mass fraction of 90% was added to the reactor, and the temperature was raised to 100°C. The reaction was carried out at a uniform rate. Under stirring, 482 g of 4-amino-2,3,5,6-tetrafluorobenzonitrile was added at a uniform rate, and the addition process was controlled to be completed within 2 hours. After the addition was completed, the reaction temperature was maintained at 100 °C to continue the reaction for 3 hours. Subsequently, 165 g of water was added to the reaction system, the sulfuric acid concentration was diluted to 80%, and the reaction temperature was raised to 120 °C and maintained at this temperature for 10 hours. After that, the reaction temperature was further increased to 130°C and the reaction was continued for 5 hours. Upon completion of the reaction, the reaction system was cooled to room temperature. Under the cooling condition, 300 g of water was added to the reaction system, and then 1715 g of 45% aqueous sodium hydroxide solution was slowly added dropwise for neutralization until the pH reached 9. After the neutralization was completed, the temperature was raised for distillation, and ultimately, 410 g of a white solid product 2,3,5,6-tetrafluoroaniline was obtained with a purity of 99.8% and a yield of 98%.

References

[1] Patent: CN107915647, 2018, A. Location in patent: Paragraph 0024; 0026; 0027; 0029
[2] C. A., 1968, vol. 69, p. 35787
[3] , Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84,

2,3,5,6-Tetrafluoroaniline Preparation Products And Raw materials

Raw materials

2,3,5,6-Tetrafluoro-4-aminobenzotrifluoride 4-Amino-2,3,5,6-tetrafluorobenzonitrile Water Sulfuric acid

Preparation Products

2,3,5,6-Tetrafluoroaniline Suppliers

Global Suppliers ( 200)
Supplier Tel Email Country ProdList Advantage
Changzhou Sifluoro Chemical Co.,Ltd 13275212658 sales@neofluoride.com China 1975 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Supplier Advantage
Changzhou Sifluoro Chemical Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Harvest Chemical Industrial Co., Ltd. 64

View Latest Price from 2,3,5,6-Tetrafluoroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3,5,6-Tetrafluoroaniline pictures 2026-09-02 2,3,5,6-Tetrafluoroaniline
700-17-4
 $1.20-35.00 1kg 99% Henan Fengda Chemical Co., Ltd
2,3,5,6-Tetrafluoroaniline pictures 2026-06-30 2,3,5,6-Tetrafluoroaniline
700-17-4
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
2,3,5,6-Tetrafluoroaniline; 2,3,5,6-Tetrafluorobenzenamine; Tetrafluoroaniline; Tetrafluorobenzenamine pictures 2020-03-26 2,3,5,6-Tetrafluoroaniline; 2,3,5,6-Tetrafluorobenzenamine; Tetrafluoroaniline; Tetrafluorobenzenamine
700-17-4
 1KG 99% 10mt Chengdu Yuanda Chemical Co., Ltd

2,3,5,6-Tetrafluoroaniline Spectrum

2,3,5,6-Tetrafluoroaniline(700-17-4)MS2,3,5,6-Tetrafluoroaniline(700-17-4)1HNMR2,3,5,6-Tetrafluoroaniline(700-17-4)IR12,3,5,6-Tetrafluoroaniline(700-17-4)IR2

700-17-4 (2,3,5,6-Tetrafluoroaniline) Related Search:

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1,3-Diamino-2,4,5,6-tetrafluorobenzene 2,3,4,6-Tetrafluoroaniline Pentafluorophenyl isothiocyanate N,N'-Bis(pentafluorophenyl)urea 2,3,5,6-Tetrafluorophenylhydrazine
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2,3,5,6-TETRAFLUOROBENZENAMINE 2,3,5,6-TETRAFLUOROANILINE 1-Amino-2,3,5,6-tetrafluorobenzene 2,3,5,6-Tetrafluoraniline Aniline, 2,3,5,6-tetrafluoro- Benzenamine, 2,3,5,6-tetrafluoro- Tetrafluoroaniline3 2,3,5,6-Tetrafluoroaniline 98% 2,3,5,6-Tetrafluoroaniline98% Tetrafluorobenzenamine 2,3,5,6-Tetrafluoroaniline ISO 9001：2015 REACH 700-17-4 700-14-7 HC6F4NH2 Organic Building Blocks Nitrogen Compounds C2 to C6 Building Blocks Amines Amines C2 to C6 Nitrogen Compounds